A5089988244- Click Chemistry and Applications
- HIV/AIDS drug development and treatment
- Synthetic Organic Chemistry Methods
- Biochemical and Molecular Research
- Carbon and Quantum Dots Applications
- Synthesis and Catalytic Reactions
- Synthesis and biological activity
- Organic Chemistry Cycloaddition Reactions
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- Graphene and Nanomaterials Applications
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and pharmacology of benzodiazepine derivatives
- Antioxidant Activity and Oxidative Stress
- Free Radicals and Antioxidants
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Phytochemicals and Antioxidant Activities
- Sulfur-Based Synthesis Techniques
- Dendrimers and Hyperbranched Polymers
- DNA and Nucleic Acid Chemistry
- Graphene research and applications
University of Messina
2016-2025
Instituto de Ciências Farmacêuticas
2016-2019
University of Catania
2016
Ospedale SS. Annunziata
2013-2014
University of Calabria
2014
Graphene quantum dots (GQD), the new generation members of graphene-family, have shown promising applications in anticancer therapy. In this study, we report synthesis a fluorescent and biocompatible nanovector, based on GQD, for targeted delivery an drug with benzofuran structure (BFG) bearing targeting ligand riboflavin (RF, vitamin B2). The highly water-dispersible nanoparticles, synthesized from multi-walled carbon nanotubes (MWCNT) by prolonged acidic treatment, were linked covalently...
2-Alkynylbenzamides underwent different reaction pathways when allowed to react under PdI2-catalyzed oxidative carbonylation conditions, depending on the nature of external nucleophile and conditions. Thus, 2-ethynylbenzamides, bearing a terminal triple bond, carried out in presence secondary amine as nucleophile, selectively led formation 3-[(dialkylcarbamoyl)methylene]isoindolin-1-ones through intermediate corresponding 2-ynamide derivatives followed by intramolecular nucleophilic attack...
Several natural antioxidants, including anthocyanins, have been reported to chemotherapeutic activity in vivo and vitro. The aim of the present study was delineate anti-proliferative cytodifferentiation properties mediated by cyanidin-3-O-β-glucopyranoside (C3G) treatment DU145 LnCap human prostatic cancer cell lines. C3G produced effects through activation caspase-3 induction p21 protein expression. reduced viability associated with a clear increase DNA fragmentation both lines after...
The spread of SARS‐CoV‐2, along with the lack targeted medicaments, encouraged research existing drugs for repurposing. rapid response to SARS‐CoV‐2 infection comprises a complex interaction cytokine storm, endothelial dysfunction, inflammation, and pathologic coagulation. Thus, active molecules targeting multiple steps in lifecycle are highly wanted. Herein we explored silico capability silibinin from Silybum marianum interact main target proteins, vitro effects against...
Abstract The click cycloaddition of azides to alkynes affording 1,2,3‐triazoles is a widely used and effective chemical transformation, applied obtain relevant products in medicine, biology, materials science. In this work, set natural deep eutectic solvents (NADESs) has been investigated the copper‐catalyzed azide‐alkyne reactions (CuAAc) as green catalytic reaction media. use these innovative shown improve effectiveness, giving excellent yields. NADESs proved be “active” their reducing...
We have studied by means of High Resolution Magic Angle Spinning Nuclear Magnetic Resonance (HR-MAS NMR) the metabolic profile famous Sicilian lemon known as 'Interdonato Lemon Messina PGI'. The PGI Interdonato possesses high organoleptic and healthy properties is recognised one most nutrient fruits. In particular, some its constituents are actively for their chemo-preventive therapeutic properties. this paper, we determined HR-MAS NMR spectroscopy molar concentration main metabolites...
The thionation reaction of carbonyl compounds with Lawesson's reagent (LR) has been studied using density functional theory methods and topological analyses. After dissociation LR, the takes place through a two-step mechanism involving (i) concerted cycloaddition between one monomer compound to form four-membered intermediate (ii) cycloreversion leading thiocarbonyl derivative phenyl(thioxo)phosphine oxide. Topological analyses confirmed concertedness asynchronicity process. second step is...
The pyrimidine nucleus is a versatile core in the development of antiretroviral agents. On this basis, series pyrimidine-2,4-diones linked to an isoxazolidine have been synthesized and tested as nucleoside analogs, endowed with potential anti-HIV (human immunodeficiency virus) activity. Compounds
Pure titanium and alloys are widely used in dentistry orthopedics. However, despite their outstanding mechanical biological properties, implant failure mainly due to post-operative infection still remains a significant concern. The possibility develop inherent antibacterial medical devices was here investigated by covalently inserting bioactive ammonium salts onto the surface of metal substrates. Titanium discs have been functionalized with quaternary (QASs) oleic acid (OA), affording...
A new template of C-4′-truncated phosphonated nucleosides (TPCOANs) has been obtained in good yields according to two different routes which exploit the reactivity a nitrone. The one-step procedure based on 1,3-dipolar cycloaddition nitrone with vinyl nucleobases leads unnatural α-nucleosides as main adducts. On other hand, target β-anomers have high yield by two-step acetate followed nucleosidation reaction. investigated trough quantum mechanical DFT calculations at B3LYP/D95+(d,p) theory...
Aloe vera L., is a plant used worldwide as folk remedy for the treatment of various ailments, including skin disorders. Its gel present in cosmetics, medicinal products and food supplements. Psoriasis, an immune-mediated chronic inflammatory disease, involving mainly skin, affects about 2–3% general population. Conventional pharmacological treatments psoriasis can have limited effectiveness cause adverse reactions. For this reason often psoriatic patients look alternative based on natural...
Coumarin is a natural compound well known for its phytotoxic potential. In the search new herbicidal compounds to manage weeds, three synthetic derivatives bearing coumarin scaffold (1–3), synthesized by carbonylative organometallic approach, were in vitro assayed on germination and root growth of two noxious Amaranthus retroflexus Echinochloa crus-galli. Moreover, coumarins 1–3 also seedlings model species Arabidopsis thaliana identify possible physiological targets. All molecules strongly...
We performed a statistical analysis of the concentration mineral elements, by means inductively coupled plasma mass spectrometry (ICP-MS), in different varieties garlic from Spain, Tunisia, and Italy. Nubia Red Garlic (Sicily) is one most known Italian that belongs to traditional food products (P.A.T.) Ministry Agriculture, Food, Forestry. The obtained results suggest concentrations considered elements may serve as geographical indicators for discrimination origin samples. In particular, we...
A total of 205 bluefin and yellowfin tuna samples were examined for mercury detection in order to verify possible differences have a detailed risk assessment the two species. The results showed significant higher concentration muscle tissue respect (p < 0.001) with mean 0.84 mg/kg maximum value 1.94 mg/kg. These can be due different biological ecological aspects species oceanographic between Atlantic Ocean Mediterranean sea. obtained this study suggest an advisable containment sources...