A5071776150- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Natural Antidiabetic Agents Studies
- Bat Biology and Ecology Studies
- Physiological and biochemical adaptations
- Humic Substances and Bio-Organic Studies
- Neurological Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Photoreceptor and optogenetics research
- Phytochemicals and Antioxidant Activities
- Isotope Analysis in Ecology
- Cholesterol and Lipid Metabolism
- Dietary Effects on Health
- Diet and metabolism studies
- Cephalopods and Marine Biology
- Retinoids in leukemia and cellular processes
- Olfactory and Sensory Function Studies
- Comparative Animal Anatomy Studies
- Seed and Plant Biochemistry
- Neurological Disease Mechanisms and Treatments
- Edible Oils Quality and Analysis
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Heavy Metal Exposure and Toxicity
Manouba University
2018-2025
Czech Academy of Sciences, Institute of Biotechnology
2025
Centre of Biotechnology of Sfax
2024
Institut Supérieur de Biotechnologie de Sfax
2011-2023
University of Monastir
1996-1997
Olive mill wastewater (OMWW), a byproduct of olive oil extraction, constitutes natural resource phenolic compounds. Hydroxytyrosol (HT), the predominant compound, exhibits antioxidant, anti‐inflammatory, and neuroprotective effects. This research aims to evaluate effect OMWW bioproduct rich in HT on retinal glial function, glutamate metabolism synaptic transmission alterations mediated by hyperglycemia dyslipidemia high‐calorie diet (HCD) induced diabetic retinopathy (DR) Psammomys obesus....
Astaxanthin is a major marine carotenoid with powerful antioxidant and neuroprotective properties. The in vitro protective effect of astaxanthin adult retinal cells the type-2 diabetic model Psammomys obesus hyperglycemic conditions was investigated. Primary were cultured normal (5 mM) or high concentrations glucose (25 40 for 5 days treated 1–20 µM last 48 h culturing. Mitochondrial dehydrogenase activity cell viability assessed using MTT test trypan blue exclusion dye. Retinal...
Salicornia is a halophyte plant that has been used in traditional medicine for the treatment of scurvy, goiter, and hypertension. It commercialized Europe Asia as fresh salads, pickled vegetables, green salt, or tea powder. This work first to assess potential anti-obesity anti-dyslipidemic effects arabica decocted extract (SADE). SADE was characterized by its significant vitro radical scavenging activity (using DPPH ABTS assays). The effect on food intake, weight loss, serum biochemical...
Diabetic retinopathy (DR) is a leading cause of blindness, yet pertinent animal models are uncommon. The sand rat (Psammomys obesus), exhibiting diet-induced metabolic syndrome, might constitute relevant model.Adult P. obesus (n = 39) were maintained in captivity for 4 to 7 months and fed either vegetation-based diets 13) or standard chow 26). Although plant-fed animals exhibited uniform body weight blood glucose levels over time, nearly 60% chow-raised developed diabetes-like symptoms (test...
Objectives: Psammomys obesus is a high-fat diet (HFD)-fed animal model of obesity and type 2 diabetes recently explored as non-proliferative diabetic retinopathy. This study tested the protective effect pigment astaxanthin (AST) in P. retina.Methods: Young adult were randomly assigned to two groups. The control group received normal consisting plant-based regimen, HFD an enriched laboratory chow. After 3 months, rodents administered vehicle or AST, daily for 7 days. Body weight, blood...
Etude sur le terrain par la methode a l'eau tritiee. Des individus de deux populations localisees, l'une en bord mer (Mahres), l'autre zone aride (Tatahouine), presentent un taux renouvellement d'eau corporelle tres eleve 40 50% jour, valeurs 2 3 fois superieures celles gerbillides desertiques granivores et nocturnes (Meriones shawi M. libycus, sympatriques P.o. Tatahouine
Abstract The purpose of this work was to evaluate a potentially useful animal model, Meriones shawi ( M.sh )—developing metabolic X syndrome, diabetes and possessing visual streak similar human macula—in the study diabetic retinopathy macular edema (DME). Type 2 (T2D) induced by high fat diet administration in . Body weights, blood glucose levels were monitored throughout study. Diabetic retinal histopathology evaluated 3 7 months after induction. Retinal thickness measured, cell types...
Purpose: To compare the retinal function of a diurnal murid rodent, Psammomys obesus, with that Wistar albino rat and human subjects.Materials methods: Adult obesus were captured transferred to animal facilities where they maintained at 25°C standard light/dark cycles natural halophilic plants, rich in water mineral salts. Standard full-field photopic scotopic electroretinograms obtained.Results: The right eye all animals displayed well detectable reproducible electroretinogram (ERG)...
In Tunisia, it was reported that Meriones shawi, a desert rodent, contaminated by heavy metals around several industrial sites. the present study, effects of cadmium (Cd) on water metabolism regulation studied in adult male shawi received diet with chloride (CdCl2) for 8 days at (1 g Cd/1 L H2O/1.5 kg granule flour). Expression arginine-vasopressin (AVP), crucial hormone regulation, immunohistochemistry hypothalamic supraoptic nucleus and paraventricular nucleus. Inspite variations intake,...
Purpose Type 2 diabetic retinopathy is the main cause of acquired blindness in adults. The aim this work was to examine retinal function sand rat Psammomys obesus as an animal model diet-induced type diabetes when subjected a hypercaloric regimen. Materials and methods Hyperglycemia induced by high caloric diet (4 kcal/g). visual control (n = 7) adult rodents were followed up during 28 consecutive weeks with full-field electroretinogram(ERG) recordings evoked flashes white light according...
To investigate the progression of diabetic retinopathy (DR) in a new diurnal animal model, we monitored clinically DR Psammomys obesus (P. obesus) during 7 months using electroretinography (ERG) and imaging techniques. After onset DR, all ERG components decreased progressively. In scotopic conditions, by 3-months disease progression, P. displayed significant decrease amplitude b-max, b-wave responses, mixed b-waves. While a-wave between 4 months. Significant differences OP2 appeared...
Une etude de la fixation du Cadmium par le rein, foie et duodenum, ses effets sur l'evolution poids corporel calcemie, a ete realisee chez Meriones shawi shawi, Gerbillide reparti en Tunisie. L'etude realisee, d'une part dans son habitat naturel, d'autre au laboratoire conditions standardisees avec un regime alimentaire temoin (granules melanges l'eau bidistillee) ou supplemente Cd une solution chlorure raison 1 g litre d'eau pour 1,5 kg granules). Sur terrain, teneur moyenne les reins des...
This work investigated the biochemical disturbances and histological alteration in
Article Apport iodé alimentaire et métabolisme thyroïdien chez deux rongeurs Gerbillidés, Meriones shawi libycus, étudiés sur le terrain en laboratoire was published on January 1, 1996 in the journal Mammalia (volume 60, issue 3).