Rajan Saxena

ORCID: 0000-0002-3122-0140
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About
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Research Areas
  • Gallbladder and Bile Duct Disorders
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Biliary and Gastrointestinal Fistulas
  • Pediatric Hepatobiliary Diseases and Treatments
  • Pancreatic and Hepatic Oncology Research
  • Liver Disease and Transplantation
  • Pancreatitis Pathology and Treatment
  • Gastric Cancer Management and Outcomes
  • Esophageal and GI Pathology
  • Peptidase Inhibition and Analysis
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Gastrointestinal disorders and treatments
  • Organ Transplantation Techniques and Outcomes
  • Liver Disease Diagnosis and Treatment
  • Viral-associated cancers and disorders
  • Gastrointestinal Tumor Research and Treatment
  • Plant Disease Resistance and Genetics
  • Neuroendocrine Tumor Research Advances
  • Abdominal Trauma and Injuries
  • Amoebic Infections and Treatments
  • Congenital Anomalies and Fetal Surgery
  • Parasitic infections in humans and animals
  • Cancer Diagnosis and Treatment
  • Cancer Genomics and Diagnostics
  • Abdominal vascular conditions and treatments

Sanjay Gandhi Post Graduate Institute of Medical Sciences
2015-2024

University of Lucknow
2024

University of Cambridge
1995-1999

Post Graduate Institute of Medical Education and Research
1988-1989

<i>Background:</i> Cholecystectomy is the most frequently performed general surgical procedure. Bile duct injury a dreaded complication and associated with serious long-term morbidity. <i>Patients Methods:</i> Three hundred patients postcholecystectomy benign biliary strictures were managed from January 1989 to February 2004 at tertiary care unit in northern India. Demographic data, clinical presentation, immediate- results of repair are analyzed prospective database....

10.1159/000097894 article EN Digestive Surgery 2006-01-01

Backgrounds/Aims Mirizzi's syndrome (MS) poses great diagnostic and management challenge to the treating physician. We presented our experience of MS cases with respect clinical presentation, difficulties, surgical procedures outcome. Methods Prospectively maintained data all surgically treated patients were analyzed. Results A total 169 managed between 1989 2011. Presenting symptoms jaundice (84%), pain (75%) cholangitis (56%). Median symptom duration s was 8 months (range, <1 240 months)....

10.14701/kjhbps.2016.20.1.17 article EN Korean Journal of Hepato-Biliary-Pancreatic Surgery 2016-01-01

Patients with long-standing extrahepatic portal venous obstruction (EHPVO) develop extensive collaterals in the hepatoduodenal ligament as a result of enlargement periportal veins. These patients are also prone to obstructive jaundice strictures and/or choledocholithiasis. Surgical management such becomes difficult presence these collaterals.To review approach EHPVO and jaundice.Retrospective requiring surgical endoscopic between 1992 2002.Thirteen (nine males, aged 12-50 years) were...

10.1111/j.1440-1746.2004.03528.x article EN Journal of Gastroenterology and Hepatology 2004-12-06

10.1007/s00534-005-1072-2 article EN Journal of Hepato-Biliary-Pancreatic Surgery 2006-07-20

Haemorrhagic complication occurs in 5-16% of patients following pancreaticoduodenectomy (PD). We report an analysis with post-PD bleed, to identify predictors survival bleed and the management bleed.Two hundred eighteen periampullary cancers underwent PD from 1989 2002. Forty-four (20.2%) had a bleeding complication. Of these, 25 intra-abdominal (IA) 21 gastrointestinal (GI) (two both IA GI bleed). Clinical, biochemical tumour characteristics were analysed factors influencing...

10.1111/j.1445-1433.2004.03212.x article EN ANZ Journal of Surgery 2004-11-01

Objective: Ampullary cancers are associated with high resectability rates and good long-term survival. However, the small number of patients in various series has hampered survival analysis. Methods: One hundred thirteen ampullary cancer underwent pancreaticoduodenectomy between 1989 2000, 48% morbidity 8% mortality. four who survived operation were analyzed to identify predictors Results: The overall median was 30.1 (1.6-140.0) months actuarial 1-, 3-, 5-year 79%, 43%, 33%, respectively....

10.1097/01.mpa.0000220864.80034.63 article EN Pancreas 2006-05-01

PURPOSEGBC usually presents in advanced stage. First-line CT is the standard of care and there no other option for responders than to wait disease progression. We conducted a randomised study consolidation CTRT versus observation first line (NCT05493956) which showed an improvement overall survival by 6 months therefore practice changing. are reporting toxicity factors predicting due so that it informs appropriate patient selection.MATERIALS & METHODSResponders (partial response, stable...

10.1016/j.adro.2024.101468 article EN cc-by-nc-nd Advances in Radiation Oncology 2024-02-08

To assess the role of preoperative biliary drainage (PBD) in early outcome following pancreaticoduodenectomy (PD) for periampullary tumors.Retrospective analysis prospective database.121 PDs were performed tumors between 1989 and 1998. 54 patients operated a PBD (group A) while 67 without PBD. 50 underwent internal 4 external drainage. Of PBD, serum bilirubin was >10 mg% 41 B) 26 had level <10 C).Patients well matched age, sex distribution, presence medical risk factors, duration surgery,...

10.1159/000050178 article EN Digestive Surgery 2001-01-01

Abstract The majority of patients with advanced carcinoma the gallbladder have irresectable disease and require palliation for jaundice, pruritus cholangitis. Intrahepatic segment III cholangiojejunostomy has been described high biliary obstruction in these patients. Forty-one stage IV cancer underwent intrahepatic cholangiojejunostomy. Subsequent cholangitis were documented; liver function tests isotope hepatobiliary scans performed. All had 29 12 Postoperative complications included...

10.1002/bjs.1800831215 article EN British journal of surgery 1996-12-01

&lt;i&gt;Background/Aims:&lt;/i&gt; External pancreatic fistula (EPF) is a common sequel to surgical or percutaneous intervention for infective complications of acute severe pancreatitis. The present study was aimed at studying the clinical profile, course and outcome patients with EPF following management these complications. &lt;i&gt;Methods:&lt;/i&gt; A retrospective analysis data (surgical percutaneous) pancreatitis managed between January 1989 April 2002 recorded on prospective database...

10.1159/000091448 article EN Digestive Surgery 2005-01-01

Gall bladder cancer (GBC) usually presents as unresectable or metastatic disease. We conducted a feasibility study to evaluate the effect of neoadjuvant therapy (NAT) on radiologic downstaging and resectability in GBC cases.Patients with locally advanced disease were treated chemoradiotherapy [CTRT] ( external radiotherapy (45Gy) along weekly concurrent cisplatin 35mg/ m2 5-FU 500 mg) those positive paraaortic nodes chemotherapy [NACT (cisplatin 25mg/m2 gemcitabine 1gm/m2 day 1 8, 3 for...

10.7314/apjcp.2016.17.4.2137 article EN cc-by Asian Pacific Journal of Cancer Prevention 2016-06-01

A residual gallbladder (RGB) following a partial/subtotal cholecystectomy may cause symptoms that require its removal. We present our large study regarding the problem of RGB over 15 year period.This involved retrospective analysis patients managed for symptomatic from January 2000 to December 2015.A was observed in 93 patients, who had median age 45 (25-70) years, and were comprised 69 (74.2%) females. The most common presentation recurrence pain (n=64, 68.8%). Associated...

10.14701/ahbps.2018.22.1.36 article EN Annals of Hepato-Biliary-Pancreatic Surgery 2018-01-01

&lt;i&gt;Objectives:&lt;/i&gt; The presentation of choledochal cysts (CDCs) is altered by complications such as acute severe cholangitis, hepatolithiasis, spontaneous perforation, portal hypertension, pancreatitis, malignancy the biliary tract and previous surgery in form internal drainage cyst. management outcome complicated differ from that an uncomplicated CDC. This analysis our experience with CDCs. &lt;i&gt;Patients Methods:&lt;/i&gt; One hundred forty-four patients CDCs were managed at...

10.1159/000111821 article EN Digestive Surgery 2007-01-01

Secondary biliary cirrhosis is a potential complication of post-cholecystectomy bile duct stricture (PCBDS). This study addresses the factors that determine severity pathological changes on liver biopsy and correlation with long-term outcome following repair.Liver biopsies obtained at surgery for repair PCBDS in 71 patients were reviewed scored from 0 to 3. Patients fibrosis score 0-2 categorized as non-cirrhotic group those 3 (secondary cirrhosis) cirrhotic group. Clinical biochemical...

10.1111/j.1440-1746.2007.04901.x article EN Journal of Gastroenterology and Hepatology 2007-03-21
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