A5059584492- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Histone Deacetylase Inhibitors Research
- Single-cell and spatial transcriptomics
- Genetics, Bioinformatics, and Biomedical Research
- Nutrition, Genetics, and Disease
- HVDC Systems and Fault Protection
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
Johannes Gutenberg University Mainz
2023-2024
Institute of Molecular Biology
2016-2020
Babraham Institute
2018
Abstract The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize in intestinal epithelia find that H3 at lysine 18 is a surprisingly abundant the small intestine crypt colon, linked show this highly dynamic regulated during cell cycle. identify class I deacetylases, HDAC1, HDAC2, HDAC3, as major executors of decrotonylation. known HDAC...
Abstract During their maturation, ribosomal RNAs (rRNAs) are decorated by hundreds of chemical modifications that participate in proper folding rRNA secondary structures and therefore function. Along with pseudouridine, methylation the 2′-hydroxyl ribose moiety (Nm) is most abundant modification rRNAs. The majority Nm eukaryotes placed Fibrillarin, a conserved methyltransferase belonging to ribonucleoprotein complex guided C/D box small nucleolar (C/D snoRNAs). These impact interactions...
Abstract During their maturation, ribosomal RNAs (rRNAs) are decorated by hundreds of chemical modifications that participate in proper folding rRNA secondary structures and therefore function. Along with pseudouridine, methylation the 2′-hydroxyl ribose moiety (Nm) is most abundant modification rRNAs. The majority Nm eukaryotes placed Fibrillarin, a conserved methyltransferase belonging to ribonucleoprotein complex guided C/D box small nucleolar (C/D snoRNAs). These impact interactions...