A5070807799- COVID-19 epidemiological studies
- Evolution and Genetic Dynamics
- Gut microbiota and health
- Reproductive tract infections research
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Vaccine Coverage and Hesitancy
- Radioactive element chemistry and processing
- Mass Spectrometry Techniques and Applications
- Chemical Synthesis and Characterization
Johns Hopkins University
2022-2025
Harvard University
2016-2020
Polarization transfer is demonstrated as a sensitive technique for the measurement of isotopic fractionation protonated carbons at natural abundance. This method allows kinetic isotope effects (KIEs) to be determined with substantially less material or shorter acquisition time compared traditional experiments. Computations quantitatively reproduce KIEs in Diels–Alder reaction and catalytic glycosylation. The glycosylation shown occur by an effectively concerted mechanism.
Antibiotic-resistant infections are a growing threat to human health, but basic features of the eco-evolutionary dynamics remain unexplained. Most prominently, there is no clear mechanism for long-term coexistence both drug-sensitive and resistant strains at intermediate levels, ubiquitous pattern seen in surveillance data. Here we show that accounting structured or spatially-heterogeneous host populations variability antibiotic consumption can lead persistent over wide range treatment...
Vaccines are a crucial tool for controlling infectious diseases, yet rarely offer perfect protection. ‘Vaccine efficacy’ describes population-level effect measured in clinical trials, but mathematical models used to evaluate the impact of vaccination campaigns require specifying how vaccines fail at individual level, which is often impossible measure. Does 90% efficacy imply protection people and no 10% (‘all-or-nothing’) or that per-exposure risk reduced by all vaccinated individuals...
The spread of SARS-CoV-2, like that many other pathogens, is governed by heterogeneity. "Superspreading," or "over-dispersion," an important factor in transmission, yet it hard to quantify. Estimates from contact tracing data are prone potential biases due the increased likelihood detecting large clusters cases, and may reflect variation behavior more than biological In contrast, average number secondary infections per routinely estimated household surveys, these studies can minimize testing...
Vaccines are a crucial tool for controlling infectious diseases, yet rarely offer perfect protection. "Vaccine efficacy" describes population-level effect measured in clinical trials, but mathematical models used to evaluate the impact of vaccination campaigns require specifying how vaccines fail at individual level, which is often impossible measure. Does 90% efficacy imply protection people and no 10% ("all-or-nothing"), or that per-exposure risk reduced by all vaccinated individuals...
The spread of SARS-CoV-2, like that many other pathogens, is governed by heterogeneity. "Superspreading," or "over-dispersion," an important factor in transmission, yet it hard to quantify. Estimates from contact tracing data are prone potential biases due the increased likelihood detecting large clusters cases, and may reflect variation behavior more than biological In contrast, average number secondary infections per routinely estimated household surveys, these studies can minimize testing...
ABSTRACT Antibiotic-resistant infections are a growing threat to human health, but basic features of the eco-evolutionary dynamics remain unexplained. Most prominently, there is no clear mechanism for long-term coexistence both drug-sensitive and resistant strains at intermediate levels, ubiquitous pattern seen in surveillance data. Here we show that accounting structured or spatially-heterogeneous host populations variability antibiotic consumption can lead persistent over wide range...