A5038480252- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Meta-analysis and systematic reviews
- Child Nutrition and Feeding Issues
- Scientific Computing and Data Management
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- scientometrics and bibliometrics research
- Homicide, Infanticide, and Child Abuse
- Research Data Management Practices
- Glycosylation and Glycoproteins Research
- Mental Health Research Topics
- Climate Change Communication and Perception
- Influenza Virus Research Studies
- Pediatric Urology and Nephrology Studies
- Neurology and Historical Studies
- COVID-19 and Mental Health
- Electroconvulsive Therapy Studies
- Biomedical Text Mining and Ontologies
- Diet and metabolism studies
- Urinary Bladder and Prostate Research
- Bipolar Disorder and Treatment
Icahn School of Medicine at Mount Sinai
2023-2024
King's College London
2018-2024
Durham University
2015
Background: Lower Urinary Tract Symptoms (LUTS significantly impact quality of life and are prevalent across course. Despite their importance, population-based incidence rates for pediatric young adult populations, including age sex-specific differences, remain poorly quantified. Methods: We analyzed data from all live-born children in Sweden between 1995 2005, with follow-up through 2018, extracted the Swedish National Medical Birth Register. employed three distinct methods to identify LUTS...
There has been a long argument over whether schizophrenia is neurodegenerative disorder associated with progressive cognitive impairment. Given high heritability of schizophrenia, ascertaning if genetic susceptibility to also decline in healthy people would support the view that leads an accelerated decline. Using population representative sample 6817 adults aged >50 years from English Longitudinal Study Ageing, we investigated associations between biennial rate ability and polygenic score...
Antipsychotic treatment resistance affects up to a third of individuals with schizophrenia, recent research finding systematic biological differences between antipsychotic resistant and responsive patients. Our aim was determine whether cognitive impairment at first episode significantly differs future responders cases.
Abstract Objective Postpartum psychosis, a mood disorder triggered by childbirth, is one of the most severe psychiatric conditions, with high risks suicide and infanticide if untreated. While it evident that genetic factors play crucial role in risk, exact extent their importance yet to be determined. Methods This cohort study consisted 1,648,759 women from Swedish nationwide registers, whom 2,514 (0.15%) experienced postpartum psychosis within three months first-ever childbirth. We...
Postpartum psychosis is a severe psychiatric condition marked by the abrupt onset of psychosis, mania, or psychotic depression following childbirth. Despite evidence for strong genetic basis, roles common and rare variation remain poorly understood. Leveraging data from Swedish national registers genomic All Us Research Program, we estimated family-based heritability at 55% WGS-based 37%, with an overrepresentation on X chromosome. Rare coding variant analysis identified DNMT1 HMGCR as...
Abstract Objective Previous studies have shown that parental factors are associated with an increased risk for attention-deficit/hyperactivity disorder (ADHD). However, the pathways by which of ADHD in offspring not well understood. These associations can arise directly from genotypes inherited offspring, and/or via environmental effects, some may themselves be influenced genotype (i.e., genetic nurture). This study specifically examines impact maternal phenotype on risk, above and beyond...
Schizophrenia is a complex disorder in which infection and immune mechanisms are thought to play role. Epidemiological ecological studies have implicated influenza particular it possible that cross-reactivity, or molecular mimicry, between the virus brain proteins underlies this association. Proteins might share amino acid sequences, could thus provide basis for an autoimmune response targets endogenous proteins. This study first characterise sequence alignment schizophrenia-related proteome...
<h3>Background</h3> There has been a long argument over whether or not schizophrenia is neurodegenerative disorder associated with progressive brain changes and increasing cognitive impairment. Building on the fact that highly heritable overlaps genetically general ability, we investigated common genetic variants additively confer stable deficit in greater risk of decline time, both, 8-year follow-up, independently from effects apolipoprotein E gene (APOE-ε4), phenotypically well-defined...
“Normal science” is a concept introduced by Thomas Kuhn in The Structure of Scientific Revolutions (1962). In Kuhn’s view, normal science means “puzzle solving”, solving problems within the paradigm—framework most successful current major scientific problems—rather than producing novelties. This paper examines Kuhnian and Popperian accounts their criticisms to assess if good. advantage according was “psychological”: subjective satisfaction from solving”. Popper argues for an “intellectual”...
Training in robust research practices is becoming increasingly common. However, many course participants may encounter challenges implementation of what they learned after returning to their groups. In this piece, we summarize insights and "lessons learned" from a group former participants. We offer practical tips on cultural change that be useful for researchers at any career stage. addition, provide list considerations instructors help them support attendees training over.
Open science is a set of practices to ensure that all research elements are transparently reported and freely accessible for learn, assess, collaboratively build on. Psychiatric genetics has led among the health sciences in implementing some open common study designs, such as replication part genome-wide association studies. However, while additional could be embedded further improve its quality accessibility, guidelines doing so limited. They largely not specific data, privacy, conduct...