Shuyuan Zhang
A5022367051- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Cancer Immunotherapy and Biomarkers
- Pneumonia and Respiratory Infections
- Gastrointestinal disorders and treatments
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Inflammation biomarkers and pathways
- Sinusitis and nasal conditions
- Plant-based Medicinal Research
- Toxin Mechanisms and Immunotoxins
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- CAR-T cell therapy research
- Amino Acid Enzymes and Metabolism
- Cancer Research and Treatments
- Oral Health Pathology and Treatment
- interferon and immune responses
Xi'an Jiaotong University
2025
Case Western Reserve University
2025
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
<p>List of signature genes expressed in BTC T cell clusters.</p>
<p>The predicted binding sites of transcription factors identified from scRNA-seq data on the CXCL13, utilizing JASPAR database.</p>
<p>Antibodies used in human sample.</p>
<p>Differentially expressed genes in ICC, ECC and GBC, respectively.</p>
<p>Antibodies and primers used in mouse sample.</p>
<p>The gene set enrichment analysis of TIL-T in three anatomical subtypes BTC.</p>
<p>The TCR overlap pattern of TIL-T among different anatomical subtypes BTC.</p>
<p>Antibodies used in human sample.</p>
<p>Single cell sequencing statistics.</p>
<p>The feature plots of representative genes in T cells BTC.</p>
<p>The transcriptome differences of TIL-T among different anatomical subtypes BTC.</p>
<p>LGALS1 was highly expressed in ICC and associated with immunosuppression of Tregs.</p>
<p>The distribution of T cell clusters in tissue origin.</p>
<p>The differentially expressed genes in GBC and pathway enrichment analysis.</p>
<p>Clinical characteristics of each sample used in scRNA-seq and scTCR-seq study.</p>
<p>TLS signature genes.</p>
<p>The TCR diversity and clonal expansion differences of TIL-T among different anatomical subtypes BTC.</p>
<p>The CXCL13+ T cells are associated with the maturation of TLS in ECC.</p>
<p>The gene set enrichment analysis of TIL-T in three anatomical subtypes BTC.</p>
<p>Interactions between T cell clusters in BTC.</p>
<p>Antibodies and primers used in mouse sample.</p>
<div>Abstract<p>Biliary tract cancer (BTC), encompassing diseases such as intrahepatic (ICC), extrahepatic cholangiocarcinoma (ECC), and gallbladder cancer, is not only increasing but also poses a significant urgent health threat due to its high malignancy. Genomic differences point the possibility that these subtypes represent distinct diseases. Elucidation of specific distribution T-cell subsets, critical immunity, across could provide better insights into unique biology BTC...
<p>Immune phenotypes and TLS mature states were correlated with anatomical subtypes in BTC.</p>
<p>The transcriptome differences of T cells from adjacent normal tissues among different anatomical subtypes BTC.</p>
<p>Supplementary Materials</p>