A5068865686- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Mathematical and Theoretical Epidemiology and Ecology Models
- Evolution and Genetic Dynamics
- Viral Infections and Outbreaks Research
- Data-Driven Disease Surveillance
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Oceanographic and Atmospheric Processes
- Ecosystem dynamics and resilience
- Mosquito-borne diseases and control
- Vibrio bacteria research studies
- Nonlinear Dynamics and Pattern Formation
- Animal Virus Infections Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Animal Disease Management and Epidemiology
- Marine and fisheries research
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- Bacillus and Francisella bacterial research
Tel Aviv University
2016-2025
Sheba Medical Center
2016-2025
Israel National Institute for Health Policy Research
2010-2024
Technion – Israel Institute of Technology
2021-2022
Alzheimer's Association of Israel
2022
Weizmann Institute of Science
2021
Hebrew University of Jerusalem
2021
Israel Ministry of Health
2021
Woods Hole Oceanographic Institution
2003-2004
On July 30, 2021, the administration of a third (booster) dose BNT162b2 messenger RNA vaccine (Pfizer-BioNTech) was approved in Israel for persons who were 60 years age or older and had received second at least 5 months earlier. Data are needed regarding effect booster on rate confirmed coronavirus 2019 disease (Covid-19) severe illness.We extracted data period from 30 through August 31, Israeli Ministry Health database 1,137,804 been fully vaccinated (i.e., two doses BNT162b2) In primary...
In December 2020, Israel began a mass vaccination campaign against coronavirus disease 2019 (Covid-19) by administering the BNT162b2 vaccine, which led to sharp curtailing of outbreak. After period with almost no cases severe acute respiratory syndrome 2 (SARS-CoV-2) infection, resurgent Covid-19 outbreak in mid-June 2021. Possible reasons for resurgence were reduced vaccine effectiveness delta (B.1.617.2) variant and waning immunity. The extent immunity is unclear.We used data on confirmed...
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides natural immunity against reinfection. Recent studies have shown waning of the provided by BNT162b2 vaccine. The time course and hybrid is unknown.Using Israeli Ministry Health database, we extracted data for August September 2021, when B.1.617.2 (delta) variant was predominant, on all persons who had been previously infected SARS-CoV-2 or received 2019 We used Poisson regression adjustment confounding...
On January 2, 2022, Israel began administering a fourth dose of BNT162b2 vaccine to persons 60 years age or older. Data are needed regarding the effect on rates confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and disease 2019 (Covid-19).Using Israeli Ministry Health database, we extracted data 1,252,331 who were older eligible for during period in which B.1.1.529 (omicron) variant SARS-CoV-2 was predominant (January 10 through March 2022). We estimated rate...
The BNT162b2 mRNA vaccine is highly effective against SARS-CoV-2. However, apprehension exists that variants of concern (VOCs) may evade protection, due to evidence reduced neutralization the VOCs B.1.1.7 and B.1.351 by sera in laboratory assays. We performed a matched cohort study examine distribution infections vaccinees from Clalit Health Services (Israel) using viral genomic sequencing, hypothesized if effectiveness VOC reduced, its proportion among breakthrough cases would be higher...
One of the significant unanswered questions about COVID-19 epidemiology relates to role children in transmission. This study uses data on infections within households order estimate susceptibility and infectivity compared those adults. The were collected from city Bnei Brak, Israel, which all household members tested for using PCR (637 households, average size 5.3). In addition, serological tests performed a subset individuals study. Inspection shows that are less likely be positive adults...
The immunogenicity and safety of the Pfizer-BioNTech BNT162b2 mRNA vaccine in people living with human immunodeficiency virus type 1 (PLWH) are unknown. We aimed to assess this PLWH.In prospective open study, we enrolled 143 PLWH, aged ≥18 years, who attended our clinic 261 immunocompetent health-care workers (HCWs). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD) IgG neutralizing antibodies were measured. Adverse events, viral load CD4 cell counts...
Abstract Full genome sequences are increasingly used to track the geographic spread and transmission dynamics of viral pathogens. Here, with a focus on Israel, we sequence 212 SARS-CoV-2 use them perform comprehensive analysis trace origins virus. We find that travelers returning from United States America significantly contributed in more than their proportion incoming infected travelers. Using phylodynamic analysis, estimate basic reproduction number virus was initially around 2.5,...
After promising initial results from the administration of a third (booster) dose BNT162b2 messenger RNA vaccine (Pfizer-BioNTech) to persons 60 years age or older, booster campaign in Israel was gradually expanded younger groups who had received second at least 5 months earlier.We extracted data for period July 30 October 10, 2021, Ministry Health database regarding 4,696,865 16 older two doses earlier. In primary analysis, we compared rates confirmed coronavirus disease 2019 (Covid-19),...
Summary The SARS-CoV-2 pandemic has been raging for over a year, creating global detrimental impact. BNT162b2 mRNA vaccine demonstrated high protection levels, yet apprehension exists that several variants of concerns (VOCs) can surmount the immune defenses generated by vaccines. Neutralization assays have revealed some reduction in neutralization VOCs B.1.1.7 and B.1.351, but relevance these real life remains unclear. We performed case-control study examined distribution observed infections...
BNT162b2 was shown to be 92% effective in preventing COVID-19. Prioritizing vaccine rollout, and achievement of herd immunity depend on SARS-CoV-2 transmission reduction. The vaccine's effect infectivity is thus a critical priority.
ABSTRACT Background Starting December 2020, Israel began a mass vaccination campaign against coronavirus administering the Pfizer BNT162b2 vaccine, which led to sharp curtailing of outbreak. After period with almost no SARS-CoV-2 infections, resurgent COVID-19 outbreak initiated mid June 2021. Possible reasons for breakthrough were reduced vaccine effectiveness Delta variant, and waning immunity. The aim this study was quantify extent immunity using Israel’s national-database. Methods Data...
Trials of the Pfizer-BioNTech BNT162b2 mRNA vaccine showed 95% efficacy in preventing symptomatic disease; however, trials excluded immunocompromised patients (ICPs). We aim at analyzing antibody response ICPs.
Israel was one of the first countries to administer mass vaccination against severe acute respiratory syndrome coronavirus 2. Consequently, it among experience substantial breakthrough infections due waning vaccine-induced immunity, which led a resurgence epidemic. In response, launched booster campaign mitigate outbreak and country do so. Israel's success in curtailing Delta while imposing only mild nonpharmaceutical interventions influenced decision many initiate campaign. By constructing...
An important aspect of vaccine effectiveness is its impact on pathogen transmissibility, harboring major implications for public health policies. As viral load a prominent factor affecting infectivity, laboratory surrogate, qRT-PCR cycle threshold (Ct), can be used to investigate the infectivity-related component effectiveness. While waning has previously been observed during Delta wave, less known regarding how Omicron affected by vaccination status, and whether vaccine-derived natural...
Abstract The worldwide shortage of vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection while the pandemic still remains uncontrolled has led many countries to dilemma whether or not vaccinate previously infected persons. Understanding level protection conferred by previous compared with that is important for policy-making. We analyzed an updated individual-level database entire population Israel assess provided both prior and in preventing subsequent...
A simple model that describes the dynamics of nutrient-driven phytoplankton blooms is presented. Apart from complicated simulation studies, very few models reported in literature have taken this "bottom-up" approach. Yet, as discussed and justified a theoretical standpoint, many are strongly controlled by nutrients rather than higher trophic levels. The analysis identifies an important threshold effect: bloom will only be triggered when exceed certain defined level. This effect should...
Various data sets related to precipitation in Israel have been analysed see whether any statistical relationships exist between the El Niño phenomenon and weather Israel. An understanding of patterns is extremely important given limited water resources Middle East. The authors seasonal rainfall, streamflow, snowfall lake level data, all these indicate enhanced during winter seasons associated with years. One intriguing finding that statistically significant correlations appear only last 25
Multihost vector-borne infectious diseases form a significant fraction of the global disease burden. In this study we explore relationship between host diversity, vector behavior, and risk. To end, have developed new dynamic model which includes two distinct species one with variable preferences. With aid were able to compute basic reproductive rate, R 0, well-established measure risk that serves as threshold parameter for outbreak. The analysis reveals system has different qualitative...
A major obstacle to eradicating polio is that poliovirus from endemic countries can be reintroduced polio-free countries. Environmental surveillance (ES) detect sewage or wastewaters samples, even in the absence of patients with paralysis. ES underused, part because its sensitivity unknown. We used two unique data sets collected during a natural experiment provided by 2013 outbreak Israel: different locations and records supplemental immunization live vaccine. Data intersecting population...