A5063279330- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Fluid Dynamics and Turbulent Flows
- DNA and Nucleic Acid Chemistry
- Cancer Immunotherapy and Biomarkers
- RNA and protein synthesis mechanisms
- Immune Cell Function and Interaction
- Fluid Dynamics and Vibration Analysis
- Religion, Spirituality, and Psychology
- Rheology and Fluid Dynamics Studies
- Advanced biosensing and bioanalysis techniques
- Tribology and Lubrication Engineering
- Combustion and flame dynamics
- HER2/EGFR in Cancer Research
- Angiogenesis and VEGF in Cancer
- vaccines and immunoinformatics approaches
- Adhesion, Friction, and Surface Interactions
- Peptidase Inhibition and Analysis
- Aerodynamics and Fluid Dynamics Research
- Galectins and Cancer Biology
- Coronary Interventions and Diagnostics
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Colorectal Cancer Treatments and Studies
Regeneron (United States)
2012-2025
University of Detroit Mercy
2012-2018
University of Liverpool
1978-2006
PIH Health
2004
Institut Pasteur
2004
University of Pennsylvania
2001-2002
University of Windsor
2000
United States Army Medical Research Institute of Infectious Diseases
1996
Bristol Royal Infirmary
1969-1987
California Institute of Technology
1984
The present article focused on the development and measurement of a factor model expressions spirituality. Study 1 (N = 534) involved use analysis to examine latent structure in sample 11 measures spiritual constructs. 2 938) replication results construction initial validation an instrument operationalize Results indicate that at least 5 robust dimensions spirituality underlie test domain. These were labeled Cognitive Orientation Towards Spirituality (COS), Experiential/Phenomenological...
Synergistic CD8 + T cell activation by antibodies to PD-1 and GITR in cancer immunotherapy depends on the CD226 costimulatory pathway.
Bispecific antibodies, while showing great therapeutic potential, pose formidable challenges with respect to their assembly, stability, immunogenicity, and pharmacodynamics. Here we describe a novel class of bispecific antibodies native human immunoglobulin format. The design exploits differences in the affinities isotypes for Protein A, allowing efficient large-scale purification. Using this format, generated antibody, REGN1979, targeting B cell marker, CD20, CD3 component T receptor, which...
The properties of cell surface proteins targeted by antibody-drug conjugates (ADCs) have not been fully exploited; particular importance are the rate internalization and route intracellular trafficking. In this study, we compared trafficking HER2, which is target clinically approved ADC ado-trastuzumab emtansine (T-DM1), with that prolactin receptor (PRLR), another potential in breast cancer. contrast to found PRLR rapidly constitutively internalized, traffics efficiently lysosomes, where it...
The Programmed Death-1 (PD-1) receptor delivers inhibitory checkpoint signals to activated T cells upon binding its ligands PD-L1 and PD-L2 expressed on antigen-presenting cancer cells, resulting in suppression of T-cell effector function tumor immune evasion. Clinical antibodies blocking the interaction between PD-1 restore cytotoxic antigen-specific yielding durable objective responses multiple cancers. This report describes preclinical characterization REGN2810, a fully human...
A CD3 bispecific antibody targeting Mucin 16 shows preclinical efficacy in mouse tumor models and a tolerable safety profile nonhuman primates.
CD28 bispecific antibodies are well tolerated and enhance the antitumor efficacy of CD3 bispecifics as a potential off-the-shelf antibody therapy.
Abstract T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind T cells via CD3 and tumor tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing cells. The promising preclinical clinical efficacy TSAxCD3 is often accompanied by toxicities such cytokine release syndrome due T-cell activation. How the toxicity profile depends on binding affinity remains unclear. Here, we evaluate that were engineered range...
Antibodies cross-linking the CD28 costimulatory pathway and a target antigen on tumors potentiate effects of checkpoint immunotherapy.
Abstract In the tumor microenvironment, multiple inhibitory checkpoint receptors can suppress T-cell function, thereby enabling immune evasion. Blockade of one these receptors, PD-1, with therapeutic antibodies has produced positive clinical responses in various cancers; however, efficacy this approach be further improved. Simultaneously targeting emerged as a promising strategy. Here, we report development and characterization REGN3767, fully human IgG4 antibody LAG-3, another receptor on T...
Anti-VEGF therapies benefit several cancer types, but drug resistance that limits therapeutic response can emerge. We generated cell lines from anti-VEGF-resistant tumor xenografts to investigate the mechanisms by which develops. Of all cells tested, only A431 (A431-V) epidermoid carcinoma developed partial VEGF inhibitor aflibercept. Compared with parental tumors, A431-V tumors secreted greater amounts of IL6 and exhibited higher levels phospho-STAT3. Notably, combined blockade receptor...
EGFR blocking antibodies are approved for the treatment of colorectal cancer and head neck squamous cell carcinoma (HNSCC). Although ERBB3 signaling has been proposed to limit effectiveness inhibitors, underlying molecular mechanisms not fully understood. To gain insight into these mechanisms, we generated potent against (REGN1400) (REGN955). We show that coactivated in multiple HNSCC lines combined blockade inhibits growth more effectively than either receptor alone. Blockade with REGN955...
We study the motion which results when a fluid film is squeezed between two parallel plane surfaces in relative motion. Particular attention given to special case where one surface fixed and other rapidly accelerated from state of rest uniform The analysis based part on linear theory substance finite-difference full nonlinear equations
Anti-vascular endothelial growth factor (VEGF) therapies have improved clinical outcomes for patients with cancers and retinal vascular diseases. Three anti-VEGF agents, pegaptanib, ranibizumab, aflibercept, are approved ophthalmic indications, while bevacizumab is to treat colorectal, lung, renal cancers, but also used off-label ocular The efficacy of relative ranibizumab in treating neovascular age-related macular degeneration has been assessed several trials. However, questions persist...
Recent clinical data demonstrate that tumors harboring MET genetic alterations (exon 14 skip mutations and/or gene amplification) respond to small-molecule tyrosine kinase inhibitors, validating as a therapeutic target. Although antibody-mediated blockade of the pathway has not been successful in clinic, failures are likely result inadequate patient selection strategies well suboptimal antibody design. Thus, our goal was generate novel blocking with enhanced efficacy.Here, we describe...
Monoclonal antibody therapies have transformed the lives of patients across a diverse range diseases. However, antibodies can usually only access extracellular proteins, including portions membrane proteins that are expressed on cell surface. In contrast, T receptors (TCRs) survey entire cellular proteome when processed and presented as peptides in association with human leukocyte antigen (pHLA complexes). Antibodies mimic TCRs by recognizing pHLA complexes potential to extend reach this...
Background: Hepatitis B virus (HBV) infection remains a significant global health challenge, leading to chronic liver disease and hepatocellular carcinoma (HCC). Natural killer (NK) cells play an important role in the clearance of HBV-infected cells, but their efficacy is often compromised during infection. Adaptive NK characterised by NKG2C expression enhanced functional responses, represent promising therapeutic avenue for enhancing anti-HBV immunity responses HBV-driven cancers. Methods:...
The osmotic stress technique was used to measure changes in macromolecular hydration that accompany binding of wild-type<i>Escherichia coli</i> lactose (<i>lac</i>) repressor its regulatory site (operator O1) the <i>lac</i> promoter and transfer from O1 nonspecific DNA. Binding at is accompanied by net <i>release</i> 260 ± 32 water molecules. If all are released surfaces, this result consistent with a reduction solvent-accessible surface area 2370 550 Å22The Protein Data Bank can be accessed...
This paper develops numerical models of stationary, axisymmetric, force-free black hole magnetospheres, based on the theory originally developed by Blandford & Znajek and reformulated extended Macdonald Thorne. The structure such a magnetosphere is determined single scalar ‘stream function’ satisfying nonlinear, second-order partial differential equation’ region bounded horizon, accretion disk, an outer boundary beyond which condition breaks down. stream equation solved numerically, using...