A5002907610- Lipid Membrane Structure and Behavior
- Aortic aneurysm repair treatments
- Force Microscopy Techniques and Applications
- Phagocytosis and Immune Regulation
- Aortic Disease and Treatment Approaches
- Sphingolipid Metabolism and Signaling
- Galectins and Cancer Biology
- Spectroscopy and Quantum Chemical Studies
- Glycosylation and Glycoproteins Research
- Pickering emulsions and particle stabilization
- Erythrocyte Function and Pathophysiology
- Cardiovascular Health and Disease Prevention
- Proteins in Food Systems
- Cardiac, Anesthesia and Surgical Outcomes
- Electrostatics and Colloid Interactions
- Complement system in diseases
- Toxin Mechanisms and Immunotoxins
- Cardiovascular Disease and Adiposity
- Analytical Chemistry and Chromatography
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Granular flow and fluidized beds
- Cellular transport and secretion
- Adhesion, Friction, and Surface Interactions
- Biochemical and Structural Characterization
University of Chicago
2014-2024
Chicago Institute for Psychoanalysis
2015-2019
University of Illinois Chicago
2017
School of the Art Institute of Chicago
2017
Colloidal particles can bind to fluid interfaces with a capillary energy that is thousands of times the thermal energy. This phenomenon offers an effective route emulsion and foam stabilization where stability influenced by phase behavior particle-laden interface under deformation. Despite vast interest in interfaces, key factors determine collapse such compression have remained relatively unexplored. In this study, we illustrate significance particle surface wettability presence electrolyte...
Significance Structural immunology employs static, atomic-level representations to uncover the molecular mechanisms by which immune receptors sensitively discern infection and disease. Lipid membranes, particularly those exposing phosphatidylserine lipids, are now understood be important signals in various aspects of regulation. However, dynamic nature lipid membranes makes standard tools structural poorly suited these systems, leaving a large gap our understanding. Here we implement suite...
The compressional instability of particle-laden air/water interfaces is investigated with plain and surface-anisotropic (Janus) particles. We hypothesize that the amphiphilic nature Janus particles leads to both anisotropic particle–particle particle–interface interactions can yield particle films unique collapse mechanisms. Analysis Langmuir isotherms microstructural characterization homogeneous polystyrene during compression reveal an interfacial buckling followed by folding, which in good...
Clinical imaging modalities are a mainstay of modern disease management, but the full utilization imaging-based data remains elusive. Aortic is defined by anatomic scalars quantifying aortic size, even though progression initiates complex shape changes. We present an geometric descriptor, inspired fundamental ideas from topology and soft-matter physics that captures dynamic evolution. The aorta reduced to two-dimensional mathematical surface in space whose geometry fully characterized local...
X-ray diffraction of sphingomyelin-dihydrocholesterol (SM-DChol) monolayers revealed short-ranged ($\ensuremath{\sim}25\text{ }\text{ }\AA{}$) 2D ordering. These nanoclusters show two distinct regions: below the cusp point phase diagram (35 mol% DChol), a constant $d$ spacing was observed; above cusp, increases linearly with DChol in accordance to Vegard's law for binary alloys. The components this lipidic alloy are thus $65\ensuremath{\mathbin:}35$ SM-DChol entity and excess DChol....
Adding small fractions of cholesterol decreases the interfacial viscosity dipalmitoylphosphatidylcholine (DPPC) monolayers by an order magnitude per wt %. Grazing incidence X-ray diffraction shows that at these does not mix ideally with DPPC but rather induces nanophase separated structures ordered, primarily phase bordered a line-active, disordered, mixed DPPC-cholesterol phase. We propose free area in classic Cohen and Turnbull model is inversely proportional to number molecules coherence...
Some synthetic polymers can block cell death when applied following an injury that would otherwise kill the cell. This cellular rescue occurs through interactions of with membranes. However, general principles for designing to ensure strong, but nondisruptive, membrane targeting are not fully elucidated. Here, we tailored biomimetic phosphorylcholine-containing copolymers interact membranes and determined their efficacy in blocking neuronal oxygen-glucose deprivation. By adjusting...
Endovascular aortic repair is the common approach for abdominal aneurysms, but endoleaks remain a significant problem with long-term success. Endoanchors have been found to reduce incidence of type 1A and can treat intraoperative 1a endoleaks. However, little known about optimal number position endoanchors achieve best outcome.
Introduction: Strength and structural stability of the aorta primarily comes from collagen that is mostly found in media layer along with elastin. The risk life-threatening aortic rupture increases cases aneurysm diseases due to local deformation weakening wall. How does structure affect how responds stress? We hypothesize material geometric heterogeneity biomechanics wall responses stress are not necessarily same as global response. Our goal develop a novel finite element model (FEM)...
Total reflection x-ray fluorescence (TXRF) is a widely applicable experimental technique for studying chemical element distributions across finely layered structures at extremely high sensitivity. To promote and facilitate scientific discovery using TXRF, we developed MATLAB-based software package with graphical user interface, named XeRay, quick, accurate, intuitive data analysis. XeRay lets the model any system, each layer its independent composition thickness, enables fine-tuned fitting....