A5028788934- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Dementia and Cognitive Impairment Research
- Neurogenesis and neuroplasticity mechanisms
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Metabolism and Genetic Disorders
- Renin-Angiotensin System Studies
- Circadian rhythm and melatonin
- Migraine and Headache Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diet and metabolism studies
- Adenosine and Purinergic Signaling
- Biochemical effects in animals
- Neuroscience of respiration and sleep
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Drug Transport and Resistance Mechanisms
- Nerve injury and regeneration
- Traumatic Brain Injury and Neurovascular Disturbances
Universidade Federal de São Paulo
2014-2024
Fundação de Apoio à Universidade Federal de São Paulo
2002-2018
Universidade de São Paulo
2006
Instituto do Coração
2006
Humboldt-Universität zu Berlin
2005
Inserm
2005
Boston Children's Hospital
2005
Harvard University
2005
Albert Einstein College of Medicine
2005
Instituto de Neurologia Y Neurocirugia
2002
Summary: Rats subjected to structural brain damage induced by sustained convulsions triggered systemic administration of pilocarpine (PILO) are a useful model for investigation the mechanisms essential seizure generation and spread in rodents. After PILO administration, three distinct phases observed: (a) an acute period 1–2 days’ duration corresponding pattern repetitive limbic seizures status epilepticus; (b) seizurefree (silent) characterized progressive return normal EEG behavior 4–44...
Abstract There is a great deal of evidence showing the capacity physical exercise to enhance cognitive function, reduce anxiety and depression, protect brain against neurodegenerative disorders. Although effects are well documented in mature brain, influence developing has been poorly explored. Therefore, we investigated morphological functional hippocampal changes adult rats submitted daily treadmill during adolescent period. Male Wistar aged 21 postnatal days old (P21) were divided into...
Aging is often accompanied by cognitive decline, memory impairment and an increased susceptibility to neurodegenerative disorders. Most of these age-related alterations have been associated with deleterious processes such as changes in the expression inflammatory cytokines. Indeed, higher levels pro-inflammatory cytokines lower anti-inflammatory are found aged brain. This perturbation pro- balance can represent one mechanisms that contribute age-associated neuronal dysfunction brain...
Piperine, an alkaloid present in the Piper genus, was shown to have anticonvulsant activity, evaluated by pilocarpine-induced model, mice. Pilocarpine (350 mg/kg, i.p.) administered 30 min after piperine (2.5, 5, 10 and 20 which significantly increased latencies 1st convulsion death, percentage of survivals. These parameters were also pilocarpine groups pretreated with atropine plus (10 2.5 respectively), as related group. However, they not altered memantine (a NMDA-type glutamate receptors...
Chronic migraine (CM) has been associated with idiopathic intracranial hypertension without papilloedema (IIHWOP), a significant percentage of these cases occurring in obese patients intractable headache. A prospective study from February 2005 to June 2006 was made 62 CM who fulfilled International Headache Society diagnostic criteria and had cerebral magnetic resonance venography (MRV) lumbar puncture (LP) done. Two were excluded, six (10%) elevated cerebrospinal fluid (CSF) open pressure...
Parkinson's disease is a neurodegenerative disorder where the main hallmark dopaminergic neuronal loss. Besides motor symptoms, PD also causes cognitive decline. Although current therapies focus on restoration of dopamine levels in striatum, prevention or disease-modifying are urgently needed. Valproic acid (VA) wide spectrum antiepileptic drug, exerting many biochemical and physiological effects. It has been shown to inhibit histone deacetylase which seems be associated with drug...
Valproic acid (VA) is used worldwide as an antiepileptic drug and a mood stabilizer. Recently, VA was shown to act on cell growth, differentiation apoptosis, by regulating gene expression at the molecular level, through epigenetic mechanisms. Thus, demonstrated chromatin remodeling what consequence of inhibition histone deacetylases (HDACs) activity. Other studies uncovered potential interfere with multiple regulatory mechanisms besides HDACs, GSK3 alpha beta, Akt, ERK phosphoinositol...
To evaluate changes in neurotransmission induced by a psychoactive beverage ayahuasca the hippocampus and amygdala of naive rats.The level monoamines, their main metabolites amino acid neurotransmitters concentrations were quantified using high performance liquid chromatography (HPLC). Four groups rats employed: saline-treated receiving 250, 500 800 mg/kg infusion (gavage). Animals killed 40 min after drug ingestion structures stored at -80 °C until HPLC assay. The data from all compared...
Summary: Purpose: This study was performed to the role of adenosine triphosphate (ATP) in brain pilocarpine‐induced chronic epileptic rats. Methods: ATP‐mediated changes intracellular calcium were studied by fura‐2 method. Immunohistochemistry and Western blotting methods used localize quantify P2X7 receptors these animals. Results: The fluorimetric rats revealed a biphasic response indicating presence receptors. showed an increase 80% expression compared with control group. immunoreactivity...
As reported by several authors, angiotensin II (AngII) is a proinflammatory molecule that stimulates the release of inflammatory cytokines and activates nuclear factor kappaB (NFkappaB), being also associated with increase cellular oxidative stress. Its production depends on activity converting enzyme (ACE) hydrolyzes inactive precursor I (AngI) into AngII. It has been suggested AngII underlies physiopathological mechanisms brain disorders such as stroke, bipolar disorder, schizophrenia,...
Chronic migraine (CM) is a common disorder, affecting 2% to 3% of the general population. Glutamate implicated in cortical spreading depression, trigeminovascular activation, central sensitization, and may be linked chronification. Triptans brought novel option for acute treatment. As development sensitization impacts upon effectiveness triptan therapy, we hypothesized that glutamate might related response mechanisms.We studied 19 patients diagnosed with CM according International Headache...