A5079475850- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Sepsis Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Appendicitis Diagnosis and Management
- Enhanced Recovery After Surgery
- Stress Responses and Cortisol
- Pancreatic and Hepatic Oncology Research
- Adrenal Hormones and Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diverticular Disease and Complications
- Renal cell carcinoma treatment
- Electrolyte and hormonal disorders
- Immune Response and Inflammation
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Pelvic floor disorders treatments
- Abdominal Surgery and Complications
- Hernia repair and management
- Gallbladder and Bile Duct Disorders
- Hormonal and reproductive studies
- Esophageal and GI Pathology
- Colorectal and Anal Carcinomas
- Abdominal Trauma and Injuries
Queen Elizabeth Hospital
2018-2024
The University of Adelaide
2018-2024
Flinders University
2011-2024
Mount Medical Centre
2009-2022
Technische Universität Braunschweig
2013
Ludwig-Maximilians-Universität München
1998-2007
University of Alabama at Birmingham
2006
Klinik und Poliklinik für Neurologie
2001
Brown University
1996-2000
Rhode Island Hospital
1996-2000
To determine: a) whether the cell-mediated immune response during sepsis differs in females vs. males; and b) survival rate is different than males after a septic insult.A prospective, randomized animal study.University research laboratory.Male female proestrus C3H/HeN mice.After anesthesia, male mice underwent cecal ligation puncture to induce sepsis. The were killed at 24 hrs onset of sepsis.Splenocyte proliferation, as well splenocyte interleukin (IL)-2 IL-3 release, was determined by...
Hypothesis: Preoperative radiochemotherapy for advanced rectal cancer results in fewer lymph nodes detected the tumor-bearing specimen.Design: Nonrandomized control trial with analysis of a prospective perioperative database.
To prove safety and effectiveness of a lipid emulsion enriched with n-3 fatty acids from fish oil (Lipoplus) within the setting parenteral nutrition patients after major abdominal surgery to determine whether there are effects on outcome parameters.Prospective, randomized, double-blind, multicenter trial.University surgical teaching hospitals.After obtaining informed consent, 256 undergoing were randomized. Parameters safety, effectiveness, routine laboratory parameters, complication rates,...
<h3>Objective:</h3> To determine whether male sex steroids contribute to the depression in cell-mediated immunity following trauma-hemorrhage and resuscitation. <h3>Design:</h3> Two weeks before induction of soft-tissue trauma (2.5-cm midline laparotomy) hemorrhagic shock (mean [±SEM] blood pressure, 35±5 mm Hg), C3H/HeN mice were castrated or sham castrated. Following trauma-hemorrhage, resuscitated killed 24 hours thereafter obtain whole spleen. <h3>Results:</h3> Splenocyte proliferation...
<h3>Hypothesis</h3> Laparoscopy has become a popular approach for the surgical treatment of benign and even malignant colorectal diseases. Several authors have reported better preserved immunity in patients undergoing laparoscopic compared with conventional surgery. The present study addresses hypothesis that specific nonspecific are differently affected by <h3>Design</h3> Nonrandomized control trial. <h3>Setting</h3> University hospital. <h3>Patients</h3> Seventy prospectively enrolled...
Recent studies suggest beneficial effects of castration before soft tissue trauma and hemorrhagic shock on splenocyte immune functions. Nonetheless, it remains unknown whether this effect testosterone depletion is limited to splenocytes or a generalized function. The present study was therefore carried out determine androgen trauma-hemorrhage also has salutary splenic peritoneal macrophage as well Kupffer cell function, indicated by interleukin (IL)-1 IL-6 release. Male C3H/HeN mice were...
Significant differences exist in the immunological response to surgery. This raises possibility that gender concerning outcome after curative colorectal cancer resection.To study this hypothesis, a database of patients with was analysed prospectively.Some 894 were included, 500 (55.9 per cent) men and 394 (44.1 women. Median follow-up 54.5 months for entire group 63.3 survivors. The mean(s.e.m.) patient age 65.3(0.4) years (women 66.1(0.6), 64.7(0.5) years; P < 0.05). Women lived...
Recent studies indicate beneficial effects of androgen depletion in male mice, before trauma-hemorrahge on cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. Nonetheless, it remains unknown whether receptor blockade the insult has any salutary effects. To study this, C3H/HeN mice were either sham-operated or subjected to (i.e., 2.5 cm midline laparotomy) followed by shock (blood pressure 35 ± 5 mmHg for 90 min) then adequately resuscitated (shed blood lactated...
Objective To determine the contribution of soft-tissue trauma plus hemorrhage, bone fracture and as well fracture, hemorrhage on host immune function. Subjects Adult male mice (n = 6/group). Design Prospective, randomized, controlled study. Setting Animal laboratory at a university-affiliated hospital. Interventions Closed-bone (right lower leg; external fixation) and/or (2.5-cm midline laparotomy, closed in two layers) were induced before hemorrhagic shock (mean arterial blood pressure 35...
Recent clinical data indicate that fast-track surgery (multimodal rehabilitation) leads to shorter postoperative length of hospital stay, faster recovery gastrointestinal function as well reduced morbidity and mortality rates. To date, no study has focused on the effects immune function. This was initiated determine whether rehabilitation results in improved immunological outcome patients undergoing colorectal surgery.Forty underwent either conventional or after surgery. In addition...
The objective of this study was to evaluate the accuracy and complication rate CT fluoroscopy-guided percutaneous core biopsies pancreas in patients with a suspected pancreatic neoplasm.Sixty-three CT-guided were performed 57 consecutive over period 20 months. Forty-nine had malignant lesion (85.9%). All procedures done under fluoroscopic guidance. A high-speed biopsy gun 14, 16, or 18 gauge cutting-type needles used. Based on final pathologic diagnosis as standard reference, diagnostic...
Abstract Background Ward rounds are crucial to providing high‐quality patient care in hospitals. round quality is strongly linked outcomes, yet ward best practice severely underrepresented the literature. Accurate and thorough documentation essential improving communication outcomes. Methods A prospective observational cohort study was performed by reviewing 135 audio‐visual recordings of surgical over 2 years at two Recordings were transcribed, an external reviewer stratified discussion...
Preoperative chemoradiotherapy for advanced rectal cancer has been an important therapeutic tool to improve the long-term results of curative resection. It is not known whether preoperative influences perioperative course immune parameters.Thirty patients with underwent surgery (study group, n = 15) or without (control (2 cycles 5-fluorouracil, 45 Gy). Blood samples were taken before neoadjuvant therapy, preoperatively, and on Days 1, 2, 5 after surgery. Cell numbers lymphocyte...