A5002719929- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Nonmelanoma Skin Cancer Studies
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Hidradenitis Suppurativa and Treatments
- COVID-19 Impact on Reproduction
- Infant Nutrition and Health
- Urticaria and Related Conditions
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Skin Protection and Aging
- SARS-CoV-2 and COVID-19 Research
- Nail Diseases and Treatments
- Colorectal and Anal Carcinomas
- Retinoids in leukemia and cellular processes
- Cutaneous Melanoma Detection and Management
- Hedgehog Signaling Pathway Studies
- Chemotherapy-related skin toxicity
- Photodynamic Therapy Research Studies
- Antifungal resistance and susceptibility
- melanin and skin pigmentation
- Allergic Rhinitis and Sensitization
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cytokine Signaling Pathways and Interactions
University of Rome Tor Vergata
2016-2025
Policlinico Tor Vergata
2021
Universidade do Porto
2017
Lactoferrin (Lf) is a cationic glycoprotein synthetized by exocrine glands and present in all human secretions. It also secreted neutrophils infection inflammation sites. This possesses antimicrobial activity due to its capability chelate two ferric ions per molecule, as well interact with bacterial viral anionic surface components. The features of Lf bind cells, protecting the host from injuries. Its anti-inflammatory mediated ability enter inside nucleus thus inhibiting synthesis...
Lactoferrin (Lf), a multifunctional cationic glycoprotein synthesized by exocrine glands and neutrophils, possesses an in vitro antiviral activity against SARS-CoV-2. Thus, we conducted vivo preliminary study to investigate the effect of oral intranasal liposomal bovine Lf (bLf) asymptomatic mild-to-moderate COVID-19 patients. From April 2020 June 2020, total 92 (67/92) (25/92) patients were recruited divided into three groups. Thirty-two (14 hospitalized 18 home-based isolation) received...
Psoriasis is a common inflammatory skin condition, affecting 2-4% of the worldwide population. remains an important public health challenge because there are many clinical forms psoriasis in particular sites, probably related to dysregulation different cytokines. Therefore, continuous need improve treatment options with mechanisms action from those currently known therapies. Advances knowledge molecular bases pathogenesis lead better understanding disease, thus influencing development and...
Tildrakizumab is a humanized IgG1κ monoclonal antibody that selectively targets the p19 subunit of interleukin IL-23, thereby inhibiting IL-23/IL-17 axis, which primarily implicated in immunopathogenesis psoriasis. approved for treatment moderate-to-severe plaque-type psoriasis adults based on evidence two randomized and controlled phase-III clinical trials (reSURFACE 1 reSURFACE 2). Here, we report our real-life experience treating 53 psoriatic patients (19 female 34 male) who were...
Psoriasis is a chronic, immune-mediated inflammatory skin condition marked by erythematous, scaly plaques. This retrospective observational study evaluated the long-term efficacy and safety of bimekizumab, dual IL-17A IL-17F inhibitor, in treating moderate to severe plaque psoriasis 56 patients across two dermatology clinics Italy. Adult participants with baseline Area Severity Index (PASI) >10, or <10 sensitive area involvement, were followed for 16 52 weeks. Clinical outcomes measured PASI...
<b><i>Background/Aims:</i></b> Hidradenitis suppurativa (HS), a chronic inflammatory skin disease of the hair follicle, can lead to scarring and disability. With an estimated European prevalence 1%, few epidemiological studies HS have been performed, none focused on hospitalisations. We aimed study time trends hospitalisations evaluate demographic characteristics, hospital incidence rate, readmissions, length stay, comorbidities risk factors hospitalised patients....
Psoriasis is a chronic immune-mediated inflammatory skin disorder, with prevalence of 2% to 3% worldwide. Psoriatic lesions affecting scalp, nails, palms, and soles are considered difficult-to-treat require specific management. When psoriasis involves these areas, it may be more severe even if the not extensive. Adalimumab (Humira) fully human monoclonal antibody against tumor necrosis factor (TNF), administered via subcutaneous injection. It has already been used in treatment adults...
Purpose Psoriasis, Psoriatic Arthritis and Nail psoriasis are chronic diseases that share a common underlying etiology of immunity dysregulation, enhanced activation inflammatory pathways remitting-relapsing course. Although nails represent small percentage the body surface involvement this site can lead to impaired quality life, severe discomfort even result in permanent disability. Current therapeutic options for nail include variety topical systemic treatments although they often reported...
Aspergillus fumigatus is the most common opportunistic fungal pathogen and causes invasive pulmonary aspergillosis (IPA), with high mortality among immunosuppressed patients. The fungistatic activity of all- trans retinoic acid (ATRA) has been recently described in vitro .
When psoriasis affects scalp, nails, palms and soles, it is considered difficult to treat causes severe impairment of life quality.We evaluated which site most impacts on the patient's quality how changes during treatment.We conducted a prospective observational study in patients receiving adalimumab over 24 weeks period, through assessment at 0, 4 using PASI, PAIN VAS, ITCH DLQI, NAPSI, PSSI. Pearson correlation was used evaluate relationship between various measurements basis three...
ABSTRACT Lactoferrin, a multifunctional cationic glycoprotein, secreted by exocrine glands and neutrophils, possesses an antiviral activity extendable to SARS-CoV-2. We performed in vitro assays proving lactoferrin through direct attachment both virus cell surface components. This varied according concentration (100/500μg/ml), multiplicity of infection (0.1/0.01) type (Vero E6/Caco-2 cells). Interestingly, the silico results strongly supported hypothesis recognition between Spike S thus...
This open-label multicentre trial evaluated the efficacy and safety of oral dimethyl fumarate (DMF) in patients with moderate-to-severe plaque psoriasis real-life clinical practice over 52 weeks. Disease severity improvement were assessed using area index (PASI), body surface (BSA) affected, Physician Global Assessment (PGA). Quality life (QoL) was Dermatology Life Index (DLQI) questionnaire. The visual analogue scale (VAS) used to quantify pruritus measure treatment satisfaction. A total...
Omalizumab is a recombinant humanized anti-IgE monoclonal antibody, approved for patients affected by chronic spontaneous urticaria resistant to antihistamines. Although the clinical benefit of omalizumab has been established in several trials, there are very little data about long-term treatment with this drug and real-life reports regarding its use comorbidities other than lacking.To assess efficacy safety heterogeneous population real-world setting.Patients weekly activity score >16...