A5068071247- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Immunodeficiency and Autoimmune Disorders
- Cutaneous lymphoproliferative disorders research
- Mast cells and histamine
- Agriculture Sustainability and Environmental Impact
- Antifungal resistance and susceptibility
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Allergic Rhinitis and Sensitization
- Hidradenitis Suppurativa and Treatments
- Urticaria and Related Conditions
- Eosinophilic Esophagitis
- Streptococcal Infections and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Nonmelanoma Skin Cancer Studies
- Skin and Cellular Biology Research
- Diet and metabolism studies
- T-cell and Retrovirus Studies
- Autoimmune and Inflammatory Disorders
- Agricultural and Food Sciences
- Phosphodiesterase function and regulation
- Otitis Media and Relapsing Polychondritis
Hospital de Santo António
2023-2025
Centro Hospitalar do Porto
2021-2025
Centro de Genética Clínica
2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Hospitais da Universidade de Coimbra
2021
Tuberculosis has a major global impact. Immunocompetent hosts usually control this disease, resulting in an asymptomatic latent tuberculosis infection (LTBI). Because TNF inhibitors increase the risk of reactivation, current guidelines recommend screening before starting any biologic drug, and chemoprophylaxis if LTBI is diagnosed. Available evidence from clinical trials real-world studies suggests that IL-17 IL-23 do not reactivation. To evaluate psoriasis patients with treated or untreated...
Objective Psoriasis is a chronic inflammatory skin disease with significant physical and psychological burden, often associated comorbidities such as obesity cardiovascular disease. Current treatments include conventional systemic therapies targeted biologic non-biologic therapies, several limitations related to safety, efficacy, cost. Roflumilast, selective PDE4 inhibitor, shows potential an oral therapy for psoriasis due its anti-inflammatory effects favorable safety profile. This study...
The VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic), which has recently been described, is a monogenic autoinflammatory that primarily affects males and its onset in adulthood.The disease caused by somatic mutations the UBA1 gene (ubiquitin-like modifier activating enzyme 1), responsible for cellular processes, particularly maintaining protein homeostasis.It presents with severe progressive systemic inflammation resistant to therapy.Common symptoms include fever...