A5083355445- Atrial Fibrillation Management and Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Blood properties and coagulation
- Mast cells and histamine
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Vitamin K Research Studies
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Hemophilia Treatment and Research
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
University of Leeds
2015-2023
Kallikrein (PKa), generated by activation of its precursor prekallikrein (PK), plays a role in the contact phase coagulation and functions kallikrein-kinin system to generate bradykinin. The general dogma has been that contribution PKa cascade is dependent on action FXII. Recently this challenged studies human plasma showing thrombin generation due activity FIX also murine formation FIXa-antithrombin complexes FXI deficient mice. In study, we demonstrate high-affinity binding interactions...
The Total Thrombus-formation Analyser System (T-TAS) is a whole blood flow chamber system for the measurement of in vitro thrombus formation under variable shear stress conditions. Our current study sought to evaluate potential utility T-TAS within human and mouse blood. microchips (collagen, PL chip; collagen/tissue thromboplastin, AR chip) were used analyze platelet (PL) or fibrin-rich formation, respectively. Blood samples from humans (healthy patients with mild bleeding disorders)...
Note: The review process for this manuscript was fully handled by Christian Weber, Editor in Chief.
Human serum albumin (HSA) is the most abundant plasma protein and sensitive to glycation in vivo. The chronic hyperglycemic conditions patients with diabetes mellitus (DM) induce a nonenzymatic Maillard reaction that denatures proteins forms advanced end products (AGEs). HSA-AGE prevalent misfolded DM associated factor XII activation downstream proinflammatory kallikrein-kinin system activity without any procoagulant of intrinsic pathway.
<h3>Introduction</h3> Atrial fibrillation (AF) and coronary artery disease (CAD) are two common cardiovascular conditions associated with increased morbidity mortality. Both bring a risk of thrombosis thus antithrombotic therapy is indicated. Despite recognised treatment, stroke myocardial infarctions still occur. Accordingly, the identification patients whose haemostasis remains unimpaired by treatment valuable. <h3>Purpose</h3> To investigate differences in plasma clot properties AF CAD...
<h3>Introduction</h3> Anticoagulation use in atrial fibrillation (AF) is common, but concurrent chronic kidney disease (CKD) reduces its efficacy and potentiates the risk of bleeding. Patients with AF have a higher incidence renal impairment latter predisposes to incident AF. The co-existence both conditions leads for thromboembolic-related adverse events also paradoxical increased haemorrhagic devastating consequences individual. Assessing effect function on plasma clot properties...
<h3>Introduction</h3> Atrial fibrillation (AF) is associated with an increased risk of stroke and thromboembolism. Despite best clinical care, patients on anticoagulation therapy still suffer from thrombosis remain at haemorrhage devastating consequences. The assessment different oral anticoagulants to identify the effects plasma clots may help in identifying reasons for this. <h3>Aim</h3> To study how affect clot properties AF. <h3>Methods</h3> We studied 257 AF receiving (Warfarin (n=184),...
Background: Fibrin formation is an essential part of innate immunity, sealing off infections to limit bacterial spreading.The surface-anchored M1 protein a major virulence determinant Group A streptococcus (GAS). During early infection cleaved from the cell surface by SpeB, streptococcal protease regulated CovR/S. forms supramolecular complex with fibrinogen however impact on fibrin not known. Methods: The effects recombinant (rM1) were assessed in clots made plasma or purified incubated...