A5006403784- Optical Coherence Tomography Applications
- Ear Surgery and Otitis Media
- Photoacoustic and Ultrasonic Imaging
- Phonocardiography and Auscultation Techniques
- Angiogenesis and VEGF in Cancer
- Bacterial biofilms and quorum sensing
- Advanced Fluorescence Microscopy Techniques
- Retinal and Macular Surgery
- Spectroscopy Techniques in Biomedical and Chemical Research
- Sinusitis and nasal conditions
- Nasal Surgery and Airway Studies
- Ocular Infections and Treatments
- Water Treatment and Disinfection
- Respiratory and Cough-Related Research
- Bacterial Infections and Vaccines
- Nosocomial Infections in ICU
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- Speech and Audio Processing
- Radiomics and Machine Learning in Medical Imaging
- Cell Image Analysis Techniques
- Coronary Interventions and Diagnostics
- Image Processing Techniques and Applications
- Advanced X-ray and CT Imaging
- Legionella and Acanthamoeba research
University of Illinois Urbana-Champaign
2015-2024
United States Food and Drug Administration
2020-2023
Center for Devices and Radiological Health
2023
Office of Science
2023
University of Illinois System
2021
Food and Drug Administration
2020
Abstract Wide local excision (WLE) is a common surgical intervention for solid tumors such as those in melanoma, breast, pancreatic, and gastrointestinal cancer. However, adequate margin assessment during WLE remains significant challenge, resulting reinterventions to achieve control. Currently, no label-free imaging method available surgeons examine the resection bed vivo microscopic residual Optical coherence tomography (OCT) enables real-time high-resolution of tissue microstructure....
Biofilms in drinking water distribution systems (DWDS) could exacerbate the persistence and associated risks of pathogenic Legionella pneumophila (L. pneumophila), thus raising human health concerns. However, mechanisms controlling adhesion subsequent detachment L. with biofilms remain unclear. We determined connection between biofilm physical structure characterization using optical coherence tomography (OCT) imaging technique. Analysis OCT images multispecies grown under low nutrient...
Objective/Hypothesis In this study, optical coherence tomography (OCT) is used to noninvasively and quantitatively determine tympanic membrane (TM) thickness the presence of any middle‐ear biofilm located behind TM. These new metrics offer potential differentiate normal, acute, chronic otitis media (OM) infections in pediatric subjects. Study Design Case series with comparison group. Methods The TM 34 subjects was acquired using a custom‐built, handheld OCT system following traditional...
Mechanical and structural properties of biofilms influence the accumulation release pathogens in drinking water distribution systems (DWDS). Thus, understanding how long-term residual disinfectants exposure affects biofilm mechanical is a necessary aspect for pathogen risk assessment control. In this study, elastic modulus structure groundwater was monitored by atomic force microscopy (AFM) optical coherence tomography (OCT) during three months to monochloramine or free chlorine. After first...
Since the inception of optical coherence tomography (OCT), advancements in imaging system design and handheld probes have allowed for numerous disease diagnostics characterization structural properties tissue. OCT developers continue to reduce form factor cost, while improving performance (speed, resolution, etc.) flexibility applicability a broad range fields, nearly every clinical specialty. An extensive array components construct customized systems has also become available, with...
Otitis media (OM), an infection in the middle ear, is extremely common pediatric population. Current gold-standard methods for diagnosis include otoscopy visualizing surface features of tympanic membrane (TM) and making qualitative assessments to determine ear content. OM typically presents as acute infection, but can progress chronic OM, after numerous infections antibiotic treatments over course many months, this disease often treated by surgically inserting small tubes TM relieve...
In an institutional review board-approved study, 25 pediatric subjects diagnosed with chronic or recurrent otitis media were observed over a period of six months optical coherence tomography (OCT). Subjects followed throughout their treatment at the initial patient evaluation and preoperative consultation, surgery (intraoperative imaging), postoperative follow-up, by additional records-based observation. At each time point, tympanic membrane (at light reflex region) directly adjacent...
Evaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption resection lymphatic structure, whether nodes or axillary contents, histological examination. While reasonably effective at detection macrometastasis, majority resected are histologically negative. Improvements need to be made better detect micrometastasis, minimize eliminate complications, provide...
The biofilm chemical and physical properties in engineered systems play an important role governing pathogen transmission, fouling facilities, corroding metal surfaces. Here, we investigated how simulated drinking water composition, structure, stiffness responded to the common scale control practice of adjusting divalent ions adding polyphosphate. Magnetomotive optical coherence elastography (MM-OCE), a tool developed for diagnosing diseased tissues, was used determine this study. MM-OCE,...
Eustachian tube dysfunction can cause fluid to collect within the middle ear cavity and form a effusion (MEE). MEEs persist for weeks or months hearing loss as well speech learning delays in young children. The ability of physician accurately identify characterize signs and/or infection is crucial provide most appropriate treatment patient. Currently, infections are assessed with otoscopy, which provides limited only qualitative diagnostic information. In this study, we propose method...
Abstract The diagnosis and treatment of otitis media (OM), a common childhood infection, is significant burden on the healthcare system. Diagnosis relies observer experience via otoscopy, although for non-specialists or inexperienced users, accurate can be difficult. In past studies, optical coherence tomography (OCT) has been used to quantitatively characterize disease states OM, with involvement experts interpret correlate image-based indicators infection clinical information. this paper,...
We report on the development of a low-cost hand-held low-coherence interferometric imaging system based principle linear optical coherence tomography (Linear OCT), technique which was first proposed in early 2000s as simpler alternative to conventional time-domain and Fourier-domain OCT. A bench-top implementation is presented validated. The axial resolution, SNR, sensitivity roll-of estimated be 5.2 μm 80 dB, 3.7 dB over depth 0.15 mm, respectively. After validating system, two probe...
In the management of otitis media (OM), identification causative bacterial pathogens and knowledge their biofilm formation can provide more targeted treatment approaches. Current clinical diagnostic methods rely on visualization tympanic membrane lack real-time assessment pathogen(s) nature any that may reside behind within middle ear cavity. recent years, optical coherence tomography (OCT) has been demonstrated as an improved
Background and Objective Sarcomas are rare but highly aggressive tumors, local recurrence after surgical excision can occur in up to 50% cases. Therefore, there is a strong clinical need for accurate tissue differentiation margin assessment reduce incomplete resection recurrence. The purpose of this study was investigate the use optical coherence tomography (OCT) novel image texture‐based processing algorithm differentiate sarcoma from muscle adipose tissue. Study Design Methods In study,...
Otitis media (OM) is a common ear infection and leading cause of conductive hearing loss in the pediatric population. Current technologies such as otoscopy, pneumatic tympanometry, acoustic reflectometry are used to diagnose OM, which can reasonably with sensitivity specificity 50-90% 60-90%, respectively. However, these techniques provide limited information about physical architecture tympanic membrane (TM), or what may lie behind it. Here, we report detection nanometer-scale structural...
Objective To characterize otitis media–associated structures affixed to the mucosal surface of tympanic membrane (TM) in vivo and surgically recovered vitro samples. Study Design Prospective case series without comparison. Setting Outpatient surgical care center. Subjects Methods Forty pediatric subjects scheduled for tympanostomy tube placement surgery were imaged intraoperatively under general anesthesia. Postmyringotomy, a portable optical coherence tomography (OCT) imaging system...
Objectives: Wideband acoustic immittance (WAI) noninvasively assesses middle ear function by measuring the sound conduction over a range of audible frequencies. Although several studies have shown potential WAI for detecting presence effusions (MEEs), determining effects MEE type and amount on in vivo has been challenging due to anatomical location cavity. The purpose this study is correlate measurements with physical characteristics MEEs determined optical coherence tomography (OCT),...
A middle ear infection is a prevalent inflammatory disease most common in the pediatric population, and its financial burden remains substantial. Current diagnostic methods are highly subjective, relying on visual cues gathered by an otoscope. To address this shortcoming, optical coherence tomography (OCT) has been integrated into handheld imaging probe. This system can non-invasively quantitatively assess effusions identify presence of bacterial biofilms cavity during infections....