A5091059016- Galaxies: Formation, Evolution, Phenomena
- Astronomy and Astrophysical Research
- Astrophysics and Star Formation Studies
- Stellar, planetary, and galactic studies
- Single-cell and spatial transcriptomics
- Astronomical Observations and Instrumentation
- Congenital heart defects research
- Astrophysical Phenomena and Observations
- Pituitary Gland Disorders and Treatments
- Astrophysics and Cosmic Phenomena
- CCD and CMOS Imaging Sensors
- Gene expression and cancer classification
- Spectroscopy and Laser Applications
- Growth Hormone and Insulin-like Growth Factors
- RNA Research and Splicing
- Reproductive Biology and Fertility
- Calibration and Measurement Techniques
- Gamma-ray bursts and supernovae
- TGF-β signaling in diseases
- Adaptive optics and wavefront sensing
- Genomics and Chromatin Dynamics
- Real-time simulation and control systems
- Atmospheric Ozone and Climate
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
Cedars-Sinai Medical Center
2023-2024
Icahn School of Medicine at Mount Sinai
2018-2023
University of Geneva
2011-2017
Observatoire de la Côte d’Azur
2015
Trinity House
2014
Columbia University
2005-2012
California Institute of Technology
2008-2011
We present accurate photometric redshifts (photo-z) in the 2-deg2 COSMOS field. The are computed with 30 broad, intermediate, and narrowbands covering UV (Galaxy Evolution Explorer), visible near-IR (NIR; Subaru, Canada–France–Hawaii Telescope (CFHT), United Kingdom Infrared Telescope, National Optical Astronomy Observatory), mid-IR (Spitzer/IRAC). A χ2 template-fitting method (Le Phare) was used calibrated large spectroscopic samples from Very Large Visible Multi-Object Spectrograph Keck...
We follow the galaxy stellar mass assembly by morphological and spectral type in COSMOS 2 deg2 field. derive functions densities from z = to 0.2 using 196,000 galaxies selected at F3.6 μm > 1 μJy with accurate photometric redshifts ( i+ < 22.5). Using a classification, we find that ∼ is an epoch of transition quiescent galaxies. Their density increases 1.1 dex between 1.5–2 0.8–1 (Δt 2.5 Gyr), but only 0.3 0.1 6 Gyr). Then, add information 80%–90% massive have elliptical morphology 0.8....
We present photometric redshifts and spectral energy distribution (SED) classifications for a sample of 1542 optically identified sources detected with XMM in the COSMOS field. Our template fitting classifies 46 as stars 464 nonactive galaxies, while remaining 1032 require templates an active galactic nucleus (AGN) contribution. High accuracy derived was accomplished result (1) photometry up to 30 bands high-significance detections, (2) new set SED templates, including 18 hybrids covering...
We report the final optical identifications of medium-depth (∼60 ks), contiguous (2 deg2) XMM-Newton survey COSMOS field. has detected ∼1800 X-ray sources down to limiting fluxes ∼5 × 10−16, ∼3 10−15, and ∼7 10−15 erg cm−2 s−1 in 0.5–2 keV, 2–10 5–10 keV bands, respectively (∼1 ∼6 ∼1 10−14 s−1, three respectively, over 50% area). The work is complemented by an extensive collection multiwavelength data from 24 μm UV, available survey, for each sources, including spectroscopic redshifts ≳50%...
Abstract Spatial transcriptomics is a rapidly evolving field, overwhelmed by multitude of technologies. This study aims to offer comparative analysis datasets generated from leading in situ imaging platforms. We have spatial data serial sections prostate adenocarcinoma using the 10x Genomics Xenium and NanoString CosMx SMI Additionally, orthogonal single-nucleus RNA sequencing (snRNA-seq) was performed on same FFPE tissue establish reference for tumor’s transcriptional profiles. assessed...
We use the UV-optical color magnitude diagram in combination with spectroscopic and photometric measurements derived from SDSS sample to measure distribution of galaxies local universe (z < 0.25) their physical properties as a function specific star formation rate (SFR/M⋆) stellar mass (M⋆). Throughout this study our emphasis is on off "star-forming sequence." discuss how characteristics along sequence are related scaling relations typically for different morphological types. find, among...
We present a study of the morphological nature redshift z~0.7 star-forming galaxies using combination HST/ACS, GALEX and ground-based images COSMOS field. Our sample consists 8,146 galaxies, 5,777 which are detected in near-ultraviolet band down to limiting magnitude 25.5 (AB). make use UV estimate star formation rates, correcting for effect dust UV-slope, compute, from ACS F814W images, C,A,S,G,M20 parameters all objects our sample. observe bimodality galaxy population show that it has...
Early interactions of influenza A virus (IAV) with respiratory epithelium might determine the outcome infection. The study global cellular innate immune responses often masks multiple aspects mechanisms by which populations cells work as organized and heterogeneous systems to defeat infection, how counteracts these systems. In this study, we experimentally dissected dynamics IAV human epithelial cell interaction during early infection at single-cell level. We found that number viruses...
Abstract To provide a multi-omics resource and investigate transcriptional regulatory mechanisms, we profile the transcriptome, chromatin accessibility, methylation status of over 70,000 single nuclei (sn) from adult mouse pituitaries. Paired snRNAseq snATACseq datasets individual animals highlight continuum between developmental epigenetically-encoded cell types transcriptionally-determined transient states. Co-accessibility analysis-based identification putative Fshb cis-regulatory domain...
Despite their importance in tissue homeostasis and renewal, human pituitary stem cells (PSCs) are incompletely characterized. We describe a single nucleus RNA-seq ATAC-seq resource from pediatric, adult, aged postmortem pituitaries (snpituitaryatlas.princeton.edu) characterize cell-type-specific gene expression chromatin accessibility programs for all major cell lineages. identify uncommitted PSCs, committing progenitor cells, sex differences. Pseudotime trajectory analysis indicates that...
We have targeted two recently discovered Lyman break galaxies (LBGs) to search for dust continuum and [CII] 158 micron line emission. The strongly lensed z~6.8 LBG A1703-zD1 behind the galaxy cluster Abell 1703, spectroscopically confirmed z=7.508 z8-GND-5296 in GOODS-N field been observed with Plateau de Bure interferometer (PdBI) at 1.2mm. These observations combined those of three z>6.5 Lya emitters (named HCM6A, Himiko, IOK-1), which deep measurements were obtained PdBI ALMA. is...
We present Submillimeter Array [C ii] 158 μm and Karl G. Jansky Very Large 12CO(1–0) line emission maps for the bright, lensed, submillimeter source at z = 5.2430 behind A 773: HLSJ091828.6+514223 (HLS0918). combine these measurements with previously reported profiles, including multiple 12CO rotational transitions, i], water, [N ii], providing some of best constraints on properties interstellar medium in a galaxy > 5. HLS0918 has total far-infrared (FIR) luminosity LFIR(8−1000 μm) (1.6 ±...
The "Cosmic Evolution Survey" (COSMOS) enables the study of Spectral Energy Distributions (SEDs) Active Galactic Nuclei (AGN) because deep coverage and rich sampling frequencies from X-ray to radio. Here we present a SED catalog 413 (\xmm) selected type 1 (emission line FWHM$>2000$ km s$^{-1}$) AGN with Magellan, SDSS or VLT spectrum. SEDs are corrected for extinction, broad emission contributions, constrained variability, host galaxy contribution. We mean dispersion after above corrections...
To extend the molecular gas measurements to more typical star-forming galaxies (SFGs) with star formation rates SFR< 40 M⊙ yr-1 and stellar masses M∗< 2.5 × 1010M⊙ at z ~ 1.5−3, we have observed CO emission IRAM Plateau de Bure Interferometer 30 m telescope for five strongly lensed galaxies, selected from Herschel Lensing Survey. These observations are combined a compilation of literature. From this, infer luminosity correction factors r2,1 = 0.81 ± 0.20 r3,1 0.57 0.15 J 2 3 transitions,...
We report the first results from Hubble Infrared Pure Parallel Imaging Extragalactic Survey, which utilizes pure parallel orbits of Space Telescope to do deep imaging along a large number random sightlines. To date, our analysis includes 26 widely separated fields observed by Wide Field Camera 3, amounts 122.8 arcmin2 in total area. have found three bright Y098-dropouts, are candidate galaxies at z ≳ 7.4. One these objects shows an indication peculiar variability and its nature is uncertain....
We report on the galaxy MACSJ0032-arc at z=3.6314 discovered during Herschel Lensing snapshot Survey of massive clusters, and strongly lensed by cluster MACSJ0032.1+1808. The successful detections its rest-frame UV, optical, FIR, millimeter, radio continua, CO emission enable us to characterize, for first time such a high redshift, stellar, dust, molecular gas properties compact star-forming with size smaller than 2.5 kpc, fairly low stellar mass 4.8x10^9 Msun, moderate IR luminosity...
Discovery of a novel pituitary protein suggests new means to enhance fertility.
Context. Multi-wavelength, optical to IR/submm observations of strongly lensed galaxies identified by the Herschel Lensing Survey are used determine physical properties high-redshift star-forming close or below detection limits blank fields.
Concomitant profiling of transcriptome and chromatin accessibility in isolated nuclei can reveal gene regulatory control mechanisms health disease. We report a single nucleus multi-omics analysis protocol optimized for frozen archived postmortem human pituitaries that is also effective ovine murine skeletal muscle biopsies. Its main advantages are (1) it not limited to fresh tissue, (2) avoids tissue dissociation-induced transcriptional changes, (3) includes novel, automated quality...
We present a catalog of mid-infrared (MIR) spectra 150 infrared (IR) luminous galaxies in the Spitzer extragalactic first look survey obtained with IR spectrograph on board Space Telescope. The sample is selected to be brighter than ∼0.9 mJy at 24 μm and it has redshift distribution range [0.3, 3.5], peak z = 1. It primarily comprises ultraluminous (ULIRGs) ≳ 1 < 1, as estimated from their monochromatic rest-frame 14 luminosities. number sources that are dominated by an active galactic...
We present CO observations of 9 ULIRGs at z~2 with S(24\mu m)>1mJy, previously confirmed the mid-IR spectra in Spitzer First Look Survey. All targets are required to have accurate redshifts from Keck/GEMINI near-IR spectra. Using Plateau de Bure millimeter-wave Interferometer (PdBI) IRAM, we detect J(3-2) [7 objects] or J(2-1) [1 object] line emission 8 sources integrated intensities Ic ~(5-9)sigma. The detected a variety spectra, including strong PAH, deep silicate absorption and power-law...
Boxy and peanut-shaped bulges are seen in about half of edge-on disc galaxies. Comparisons the photometry major-axis gas stellar kinematics these to simulations bar formation evolution indicate that they bars viewed projection. If properties boxy can be entirely explained by assuming bars, then this may imply their hosts pure galaxies with no classical bulge. A handful bulges, including Milky Way, have been observed rotate cylindrically, i.e. a mean velocity independent height above disc. In...
Our objectives are to determine the properties of interstellar medium (ISM) and star-formation in typical star-forming galaxies at high redshift. Following up on our previous multi-wavelength observations with HST, Spitzer, Herschel, Plateau de Bure Interferometer (PdBI), we have studied a strongly lensed z=2.013 galaxy, arc behind galaxy cluster MACS J0451+0006, ALMA measure [CII] 158 micron emission line, one main coolants ISM. from southern part this is detected 10 $\sigma$. Taking into...
We study zCOSMOS-bright optical spectra for 609 Spitzer/MIPS 24 micron-selected galaxies with S(24um)> 0.30 mJy and I<22.5 (AB mag) over 1.5 sq. deg. of the COSMOS field. From emission-line diagnostics we find that: 1) star-formation rates (SFR) derived from observed Halpha Hbeta lines underestimate, on average, total SFR by factors ~5 10, respectively; 2) both Calzetti et al. Milky Way reddening laws are suitable to describe extinction in infrared (IR) sources most cases; 3) some IR...