A5079009399- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Crystallization and Solubility Studies
- Nanoparticle-Based Drug Delivery
- Analytical Methods in Pharmaceuticals
- Pharmacological Effects of Natural Compounds
- Oral and gingival health research
- Hepatitis B Virus Studies
- Protein purification and stability
- Geochemistry and Geologic Mapping
- biodegradable polymer synthesis and properties
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Drug-Induced Hepatotoxicity and Protection
- Drilling and Well Engineering
- Radioactive element chemistry and processing
- Pneumonia and Respiratory Infections
- Drug-Induced Adverse Reactions
- Hydrocarbon exploration and reservoir analysis
- Pharmaceutical studies and practices
- Intraperitoneal and Appendiceal Malignancies
- Antimicrobial agents and applications
- Biochemical and Structural Characterization
- Dialysis and Renal Disease Management
University of Lahore
2022-2023
Government College University, Faisalabad
2021-2023
The University of Chenab, Gujrat
2022-2023
University of Gujrat
2022-2023
OPINION article Front. Public Health, 17 January 2022Sec. Infectious Diseases – Surveillance, Prevention and Treatment Volume 9 - 2021 | https://doi.org/10.3389/fpubh.2021.794868
The occurrence of fungal infections has increased over the past two decades. It is observed that superficial are treated by conventional dosage forms, which incapable treating deep due to barrier activity possessed stratum corneum skin. This why need for a topical preparation with advanced penetration techniques arisen. research aimed encapsulate fluconazole (FLZ) in novasome order improve delivery. novasomes were prepared using ethanol injection technique and characterized percent...
The markedly low oral bioavailability of domperidone (anti-emetic drug) is associated with rapid first-pass metabolism in the intestine and liver. To counteract such affects, there a need to devise strategy enhance absorption subsequently bioavailability. Thus, current study was aimed at synthesizing phytosomes consisting phosphatidylcholine piperine (a P-glycoprotein inhibitor). Phytosomes were prepared by salting-out method. developed extensively characterized for size, zeta potential,...
The objective of this study was to improve the dissolution and solubility dexibuprofen (DEX) using hydroxypropyl beta cyclodextrin (HPβCD) inclusion complexes also evaluate effect presence hydrophilic polymers on solubilization efficiency HPβCD. Three different methods (physical trituration, kneading solvent evaporation) were used prepare binary at various drug-to-cyclodextrin weight ratios. An increase in drug release observed with (KN) method a DEX/HPβCD (1:4) ratio. addition poloxamer-188...
The main objective of this research work was the development and evaluation transfersomes integrated oral films for bioavailability enhancement Ebastine (EBT) to treat allergic rhinitis. flexible transfersomes, consisting drug (EBT), lipid (Phosphatidylcholine) edge activator (EA) Polyoxyethylene sorbitan monooleate or Sorbitan monolaurate, were prepared with conventional thin film hydration method. developed further into using solvent casting Transfersomes evaluated their size distribution,...
Orodispersible sublingual films (OSFs) composed of hydrophilic polymers were loaded with poloxamer-188 and d-α-tocopheryl polyethylene glycol succinate (TPGS-1000) mixed micelles to improve the oral bioavailability a poorly soluble drug, ebastine (EBT). Mixed formed by thin-film hydration method incorporated into orodispersible film, consisting HPMC glycerol, using solvent casting technique. The thoroughly evaluated for physicochemical characterization (size, polydispersity index, zeta...
The aim of this study was to improve the solubility and prevent ulcerogenic effect flurbiprofen. Initially, binary ternary solid dispersions (BSDs TSDs) flurbiprofen were prepared by using non-ordered mesoporous silica gelucire. After preformulation testing (solubility, flow properties, % yield, entrapment efficiency), four formulations selected for further detailed studies. Solid-state characterization optimized (S1, S6, S7, S12) showed successful drug incorporation in dispersion at...
Purpose: To investigate the efficiency of different solubilizing agents in improving solubility as well dissolution rate ebastine (a BCS class II drug) by incorporating prepared solid dispersion into fast disintegrating tablets.Method: The was determined distilled water, lipids and agents. Subsequently, binary dispersions were kneading method using varying weight ratios then incorporated tablets (SD-FDT). Central composite rotatable design (CCD) used to determine impact super on...
The objective of this study was to improve the bioavailability itraconazole (ITZ) by enhancing its solubility and dissolution through multi-components-composite (MCC). ITZ loaded MCCs were prepared using different hydrophilic polymers, lipid solubilizer, pH modifier, dispersant as well disintegrant kneading technique. Furthermore, ITZ′s saturation determined a shake flask method. developed characterized for in vitro dissolution, vivo pharmacokinetics, Fourier-transform infrared spectroscopy...
Itraconazole (ITZ) is a renowned antifungal medication, however its therapeutic efficacy limited by low solubility and oral bioavailability. The current research work attempted to augment the bioavailability of ITZ incorporating into self-emulsifying micelles (SEMCs). To fabricate SEMCs, various preparation techniques including physical mixture, melt-emulsification, solvent evaporation kneading, were opted using different weight ratio drug solubilizers i.e. Gelucire-50/13 or Gelucire-44/14...