A5007776478- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- BRCA gene mutations in cancer
- Asthma and respiratory diseases
- Mechanical Circulatory Support Devices
- Diet and metabolism studies
- Genomics and Rare Diseases
- Non-Invasive Vital Sign Monitoring
- Family Support in Illness
- Intensive Care Unit Cognitive Disorders
- Childhood Cancer Survivors' Quality of Life
- Metabolism and Genetic Disorders
- Cardiac Arrest and Resuscitation
- Nursing Roles and Practices
- Early Childhood Education and Development
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Congenital Diaphragmatic Hernia Studies
- South Asian Cinema and Culture
- Flow Measurement and Analysis
- Educational and Psychological Assessments
- Scottish History and National Identity
University of Pennsylvania
2024-2025
California University of Pennsylvania
2024
University of Canterbury
2015-2020
University Hospitals Birmingham NHS Foundation Trust
2019
Queen Elizabeth Hospital Birmingham
2019
ING Direct
2015
Introduction: Mental health, physical and cognitive skills have been scarcely investigated in the same sample of adults with PKU (AwPKU). This is striking since emotional difficulties may potentially contribute to impairments vice-versa. Here we aim fill this gap.Method: Thirty-six early-treated AwPKU 40 controls were given an extensive battery tasks assessing complex executive functions, inhibitory control, short-term memory, sustained attention, visuospatial language production (reading...
Abstract Background Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute distress syndrome (ARDS) may improve patient care and outcome. The Clinical utilisation of (CURE) trial is a two-arm, randomised controlled (RCT) investigating the performance PEEP selected an objective, model-based minimal system ARDS. Methods design CURE RCT compares two groups requiring invasive MV partial arterial oxygen/fraction inspired...
10502 Background: With FDA approval of targeted therapies in patients with germline BRCA1/2 -related advanced cancers there is a need to evaluate efficient and effective delivery models for cancer genetic testing. Methods: eREACH 4 arm non-inferiority study where traditional standard-of-care pre-test (visit 1) post-test 2) counseling delivered by counselor (GC) are replaced patient-centered eHealth (digital) intervention or metastatic cancer. GC visits were offered telehealth the home. Arms...
In the treatment of phenylketonuria (PKU), there was disparity between UK dietitians regarding interpretation how different foods should be allocated in a low phenylalanine diet (allowed without measurement, not allowed, or allowed as part exchanges). This led to variable advice being given patients.
In respiratory mechanics models, resistance is often given less focus than elastance or compliance, and the impact of simplified. Respiratory system likely to have some components that change during a breath. A variable model presented as an extension single compartment which allows linearly with pressure inspiration. The performance this tested against compartment, two using clinical datasets support ventilation, volume control ventilation combined 29346 breaths. fits data slightly better...
Respiratory mechanics of fully sedated patients can be easily estimated as the ventilator has full control patient's work breathing. However, in spontaneously breathing or whose is only partially assisted, respiratory estimation much more difficult. This difficulty caused by un-modelled and variable patient effort introduced into system. The Time-varying elastance model a that estimate with use dynamic elastance. negative component where measured airway pressure decreasing, yet air flowing...
Lung mechanics measurements provide clinically useful information about disease progression and lung health. Currently, there are no commonly practiced methods to non-invasively measure both resistive elastic during tidal breathing, preventing the important provided by from being utilised. This study presents a novel method easily assess of spontaneously breathing subjects using dynamic elastance, single-compartment model. A spirometer with built-in shutter was used occlude expiration...
Mechanical ventilation is a primary therapy for patients with acute respiratory failure. However, incorrect ventilator settings can cause further lung damage inter- and intra- patient heterogeneity an issue. Lung protective include titrating positive end-expiratory pressure (PEEP) to the point of minimum elastance. predicting elastance be difficult, use high PEEP lead induced injury. In this study, basis function resistance model developed allow information available at lower level identify...
Mechanical ventilation is a primary therapy for patients with acute respiratory failure. However, poorly selected ventilator settings can cause lung damage due to the heterogeneity of healthy and damaged alveoli. A commonly used protective strategy titrating PEEP (positive end expiratory pressure) minimum elastance. in clinical practice this initial rarely changed. As disease evolves over time, optimal required maintain recruitment also changes. predictive elastance model could be assess...
Models of respiratory mechanics can be used to titrate patient-specific mechanical ventilation (MV) settings in critical care, but often perform poorly the presence patient breathing effort. Respiratory are conventionally calculated using only inspiratory data. Muscle activity is normally assumed relatively minimal or absent during passive expiration regardless spontaneous (SB) efforts. Hence, this study assesses whether expiratory lung elastance estimate for spontaneously breathing, reverse...
Mechanical ventilation (MV) is widely used in Neonatal Intensive Care Unit (NICU) to support or fully control the breathing of patients with respiratory distress syndrome (RDS). Current clinical practice involves clinician intuition a generalized, “one size fits all” approach as inter-patient variability and lung heterogeneity can make selection optimum ventilator settings difficult. Model-based methods be identify patient-specific mechanics. This study aims apply single compartment model an...
Abstract Background Germline cancer genetic testing has become a standard evidence-based practice, with established risk reduction and screening guidelines for carriers. Access to services is limited in many places, which leaves carriers unidentified at late diagnosis of cancers poor outcomes. This poses problem childhood survivors, as this population an increased subsequent malignant neoplasms (SMN) due therapy or inherited predisposition. The ENG aging A ctivating survivors Ge netic...
Research participants have reported high interest in receiving genetic research results. However, how best to return results while honoring participants' preferences and their right refusal remains unclear. We sought evaluate uptake of actionable results, factors associated with receipt (ROR) willingness complete pre-disclosure education disclosure through a digital intervention among patients enrolled the Penn Medicine Biobank.
10009 Background: Limited access to genetic services in community practices, leaves many childhood cancer survivors who are carriers unidentified and at risk for subsequent malignant neoplasms (SMNs) due therapy or an inherited predisposition. The ENGaging Activating Genetic (ENGAGE) study evaluated the effectiveness of in-home, collaborative PCP (primary care provider) model remote centralized telehealth increase uptake compared usual care. Methods: 414 were randomized by phone...
Research participants report interest in receiving genetic research results. How best to return results remains unclear. In this randomized pilot study, we sought assess the feasibility of returning actionable through a two-step process including patient-centered digital intervention as compared with counselor (GC) Penn Medicine biobank. Step 1, an result and procedural controls (no result) were invited pre-disclosure education provided options for opting out 2, those who had not opted...
Acclaimed publisher and editor Neil Astley, founder of Bloodaxe Books, guest-edits this special transatlantic all-poetry issue, featuring poets from North America, Great Britain, Ireland. The issue contains a stirring diversity work, with writers who have roots everywhere Guyana to Pakistan Zambia, also features poetry in Welsh, Irish, Scottish Gaelic. Much the work is accomplished British are still little-known States. As Astley writes his introduction, aims break down “the illogical divide...
I was interested to read that health expert Jacky Chambers has called for mandatory training in breastfeeding all midwives (news april 7). While think this is a good idea, disappointed with the underlying negative attitude bottlefeeding story.