A5042595841- Nuclear Receptors and Signaling
- Signaling Pathways in Disease
- Cervical Cancer and HPV Research
- Macrophage Migration Inhibitory Factor
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Circular RNAs in diseases
- Economic and Financial Impacts of Cancer
- Pulmonary Hypertension Research and Treatments
Sandwell General Hospital
2023
University of Birmingham
2019-2022
Institute of Immunology
2019
Nr4a receptors are activated by T cell receptor (TCR) signaling and play key roles in differentiation. Which TCR pathways regulate their sensitivities to signal strength duration remains unclear. Using Nr4a1/Nur77-GFP Nr4a3-Timer of kinetics activity (Tocky) mice, we elucidate the governing expression. We reveal that Nr4a1-Nr4a3 Src family kinase dependent. Moreover, Nr4a2 Nr4a3 attenuated calcineurin inhibitors bind nuclear factor cells 1 (NFAT1), highlighting a necessary sufficient role...
Summary Nr4a receptors are activated by T cell receptor (TCR) and B (BCR) signalling play key roles in differentiation promoting exhaustion. How TCR pathways regulate their sensitivities to different physiological types of (e.g. tonic versus activating) remains unknown. Here we utilise Nr4a1/Nur77-GFP Nr4a3 -Tocky mice elucidate the that govern expression CD4 + CD8 cells. Our findings reveal Nr4a1-3 Src family kinase-dependent. Moreover, Nr4a2 abolished calcineurin inhibitors bind NFAT1,...