A5049857758- Scheduling and Optimization Algorithms
- Assembly Line Balancing Optimization
- Advanced Manufacturing and Logistics Optimization
- Analytical Chemistry and Chromatography
- Manufacturing Process and Optimization
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Advanced SAR Imaging Techniques
- Medical Imaging Techniques and Applications
- Biosimilars and Bioanalytical Methods
- Antibiotics Pharmacokinetics and Efficacy
- Soil Moisture and Remote Sensing
- Precipitation Measurement and Analysis
- Advanced Radiotherapy Techniques
- Lymphoma Diagnosis and Treatment
- Pharmacological Effects and Assays
- RNA modifications and cancer
- Radar Systems and Signal Processing
- Metabolomics and Mass Spectrometry Studies
- Radiomics and Machine Learning in Medical Imaging
- Energy Efficiency and Management
- Metaheuristic Optimization Algorithms Research
- Neural Networks and Applications
- Pesticide Residue Analysis and Safety
- Machine Learning and ELM
- Interactive and Immersive Displays
Sun Yat-sen University
2022-2024
Sun Yat-sen University Cancer Center
2022-2024
State Key Laboratory of Oncology in South China
2022-2024
Chongqing University
2020-2023
University of Colorado Denver
2023
University of Colorado Cancer Center
2023
GlaxoSmithKline (United States)
2018-2020
Peking Union Medical College Hospital
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2019
Beijing Institute of Radio Metrology and Measurement
2019
In the actual production, insertion of new job and machine preventive maintenance (PM) are very common phenomena. Under these situations, a flexible job-shop rescheduling problem (FJRP) with both PM is investigated. First, an imperfect (IPM) model established to determine optimal plan for each machine, optimality proven. Second, in order jointly optimize production scheduling planning, multiobjective optimization developed. Third, deal this model, improved nondominated sorting genetic...
The challenge in the imaging of high-squint-mode synthetic aperture radar (SAR) mounted on maneuvering platforms is azimuth dependence both range migration and focusing parameters (the frequency-modulation rate higher order coefficients), which are caused by walk correction acceleration. In to accommodate dependence, a modified subaperture algorithm proposed. Based fact that times corresponding same Doppler frequency different for targets gate, after making blocks domain, azimuth-dependent...
Seven dog cytochromes p450 (p450s) were heterologously expressed in baculovirus-Sf21 insect cells. Of all enzymes examined, CYP1A1 exhibited high 7-ethoxyresorufin O-deethylase activity (low Km enzyme, 1 microM). CYP2B11 and CYP3A12 effectively catalyzed the N1-demethylation C3-hydroxylation of diazepam (and its derivatives), whereas CYP2D15 exclusively N- O-demethylation, respectively, dextromethorphan. However, no saturation velocity curves for N-demethylation dextromethorphan (up to 500...
Abstract This article presents an analytical approach that used chemical derivatization to enhance mass spectrometric (MS) response in electrospray ionization (ESI) mode of 1‐hydroxypyrene (1‐OHP), a commonly biomarker monitor human exposure polycyclic aromatic hydrocarbons (PAHs). The enhancement successfully enabled the desired detection 50 pg/mL urine. introduction MS‐friendly dansyl group 1‐OHP enhanced both efficiency ESI source and collision‐activated dissociation (CAD) collision cell....
Abstract A hydrophilic interaction liquid chromatographic method with tandem mass spectrometry for the determination of atenolol, a β ‐blocking agent, in human plasma has been developed and validated over curve range 10–2000 ng/mL. The assay was based on protein precipitation followed by evaporation extraction solvent, reconstitution acetonitrile, chromatography an Hypersil silica column (50 × 4.6 mm) using low aqueous–high organic mobile phase. phase consists 85% 15% water, 0.5% acetic acid...
Complex biotherapeutics present challenges from drug discovery, screening, and development perspectives. While monoclonal antibody drugs are not monitored for metabolites in the same manner as small molecules, such fusion proteins, antibody-drug conjugates, or bispecific antibodies may undergo biotransformation (such clipping, deamidation, oxidation) vivo, resulting catabolites that can have a direct impact on safety efficacy. Here subunit LC-MS is utilized evaluation of two classes complex...
The 10th Global CRO Council (GCC) Closed Forum was held in Orlando, FL, USA on 18 April 2016. In attendance were decision makers from international member companies offering bioanalytical services. objective of this meeting for GCC members to meet and discuss scientific regulatory issues specific bioanalysis. discussed at closed forum included reporting data failed method validation runs, GCP clinical sample bioanalysis, extracted stability, biomarker assay validation, processed batch...