A5062450766- Ocular Diseases and Behçet’s Syndrome
- Ocular Surface and Contact Lens
- Vasculitis and related conditions
- Corneal Surgery and Treatments
- Systemic Lupus Erythematosus Research
- Corneal surgery and disorders
- Salivary Gland Disorders and Functions
- Proteoglycans and glycosaminoglycans research
- Otitis Media and Relapsing Polychondritis
- Retinal and Optic Conditions
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Infections and Treatments
- Retinal Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Systemic Sclerosis and Related Diseases
- Platelet Disorders and Treatments
- Herpesvirus Infections and Treatments
- Glaucoma and retinal disorders
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Peripheral Neuropathies and Disorders
Erasmus MC
2020-2024
Maastricht University Medical Centre
2023
Erasmus University Rotterdam
2021-2022
Keratoconus is characterized by the progressive thinning of cornea, which leads to a cone-like appearance eye over time. Although conventionally defined as noninflammatory condition, number recent studies have associated keratoconus (KC) with allergic conjunctivitis (AC) based on clinical parameters. This study aimed consolidate this association performing proteomic analysis tear fluid from patients and/or conjunctivitis.Of 51 patients, 17 were diagnosed KC, AC, and both KC AC (combined)....
Tear fluid forms a potential source for biomarker identification, and can be minimal invasively collected via Schirmer strips. The lack of knowledge on the processing strips however complicates analysis between-study comparisons. We studied two different pre-processing methods, specifically use punches strip versus elution in buffer. filled were from 5 healthy participants, divided into halves over length strip. In either part, or eluates obtained 4 locations, first part touching eye (head)...
Scleritis is an extremely painful and potentially blinding inflammation of the sclera with unknown pathogenesis unpredictable course. To gain insight in its disease process identify biomarker candidates, we performed extensive proteomics serum tear fluid.Prospective multicenter cohort study.A total 121 patients noninfectious scleritis (of which 39 active cases), 30 healthy controls, 23 controls (uveitis rheumatoid arthritis) were enrolled Netherlands from 2020 to 2022.Serum, fluid both eyes,...
Scleritis is a severe and painful ophthalmic disorder, in which pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies large cohort patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 scleritis multicenter study Netherlands. In addition, healthy (n = 39) uveitis controls 48) were included. Serum tested anti-native human type II collagen using validated enzyme-linked...
Scleritis is a potentially blinding disorder, with highly unpredictable course and outcome. We analyzed the prevalence clinical relevance of autoantibodies inflammatory parameters in non-infectious scleritis.Retrospective analysis laboratory findings all consecutive patients at department Ophthalmology Erasmus MC scleritis.We included 81 scleritis. A systemic autoimmune disease was present 46%. Positive anti-nuclear antibodies were found 30%, anti-neutrophil cytoplasmic positive 19%,...
Purpose: Scleritis is a severe inflammatory ocular disorder with unknown pathogenesis. We investigated healthy sclera as well affected by noninfectious scleritis for differentially expressed proteins using mass spectrometry approach. Methods: collected scleral samples of enucleated eyes due to (n = 3), and control tissues 5), all exenterated eyelid carcinomas 4), or choroidal melanoma 1) without invasion. Samples were prepared the nano liquid-chromatography spectrometer (LC-MS), data...
Abstract Tear fluid forms a potential source for biomarker identification, and can be minimal invasively collected via Schirmer strips. The lack of knowledge on the processing strips however complicates analysis between-study comparisons. We studied two different pre-processing methods, specifically use punches strip versus elution in PBS buffer. filled were from 5 healthy participants, divided into halves over length strip. In either part, or eluates obtained 4 locations, first part...
Objectives Scleritis represents a severe extra-articular manifestation of rheumatoid arthritis (RA). Recent clinical observations suggest decreasing incidence scleritis in RA, attributed to improved treatment options. Our study reports on the and characteristics RA observed biological era reflects our results historical perspective. Methods We performed retrospective evaluation all 1623 consecutive patients with diagnosed at department rheumatology between 2011 2021 Erasmus Medical Center...
To report on an unexpected side effect of Rituximab (RTX), a B-cell targeting monoclonal agent, in patient with severe sclerouveitis, leading to visual loss.Observational case report.A 61-year-old female was treated RTX for sclerouveitis occurring granulomatosis polyangiitis. Initially it responded partly high dose oral corticosteroids, however, her recurred after two months during tapering below 20mg daily. The days following the infusions, aggravation intraocular inflammation seen,...
To determine the thickness of conjunctiva, episclera and sclera in healthy individuals using anterior segment optical coherence tomography (AS-OCT).
Scleritis is a sight-threatening inflammation, which commonly accompanied by severe complications. Aggressive systemic immunosuppressive treatment, frequently needed, can be associated with serious complications, and might therefore (temporarily) contraindicated.We report on the outcomes of three patients severe, active, non-infectious scleritis, refractory or intolerant to who received subconjunctival rituximab (RTX) injections. A dose 2.5 7.5 mg was administered after topical anesthesia,...
Abstract Purpose Five patients who underwent uncomplicated retinal pigment epithelium (RPE)-choroid transplantation for neovascular age-related macular degeneration developed a destructive inflammatory reaction causing subretinal fluid accumulation and extensive RPE atrophy in the graft. We hypothesized that this inflammation could be caused by an auto-immune response against graft, resulting circulating auto-antibodies. The aim of our study was to examine potential autoimmune origin, which...
Purpose We report the long-term effect of rituximab (RTX) in scleritis and determine value B-cell monitoring for prediction relapses.Methods retrospectively studied 10 patients with scleritis, who were treated RTX. Clinical characteristics collected, blood counts measured before start RTX, at various time points after treatment.Results activity decreased RTX treatment all within a median 8 weeks (range 3–13), reached remission. The follow-up was 101 months 9–138). Relapses occurred 6 out...