A5002876907- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- RNA regulation and disease
- Diabetic Foot Ulcer Assessment and Management
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Research and Splicing
- Mesenchymal stem cell research
- Mycobacterium research and diagnosis
- Liver Disease and Transplantation
- Autophagy in Disease and Therapy
- Ion channel regulation and function
- Antibiotic Resistance in Bacteria
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Pressure Ulcer Prevention and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Polyomavirus and related diseases
- Bacterial biofilms and quorum sensing
Shaqra University
2022-2024
Suez University
2017-2024
The wound-healing process in diabetic foot is affected by pro and anti-inflammatory markers, any disruption the inflammatory reaction interferes with tissue homeostasis, leading to chronic non-wound healing. This study aimed determine diagnostic value effect of CRP, IL-6, TNF, HbA1c on initiation progression ulcers. ELISA was used quantify 205 patients diabetes, 105 were free. prevalence also evaluated. area under curve (AUC) calculated using receiver operating characteristic (ROC) analyze...
Molecular Epidemiology and Mechanisms of High-Level Resistance to Meropenem Imipenem in Pseudomonas aeruginosa Noha Anwar Hassuna,1 Marwa K Darwish,2 Mohamed Sayed,1 Reham Ali Ibrahem3 1Medical Microbiology Immunology Department, Faculty Medicine, Minia University, Minia, Egypt; 2Chemistry Department (Biochemistry Branch), Science, Suez Suez, 3Microbiology Pharmacy, EgyptCorrespondence: HassunaMedical EgyptTel +20 862342813Email nohaanwar@mu.edu.egPurpose: possesses a large number resistance...
Multiple sclerosis (MS) is a prevalent neurological disorder affecting the central nervous system, with global incidence exceeding 2.5 million cases. Brain-derived neurotrophic factor-antisense (BDNF-AS), long non-coding RNA, has been identified as factor that negatively influences expression of brain-derived factor, neurotrophin protein exhibits heightened within actively demyelinating lesions in MS. This study aims to assess relative BDNF-AS across all MS subtypes, evaluate its diagnostic...
Glioblastoma (GB) represents the most common malignant brain tumor, which, despite extensive research, remains of poor prognosis. The focus recent studies GB pathogenesis has shifted to study role noncoding RNAs (ncRNAs). In this study, we examined expression levels microRNA miR-326 and long ncRNA H19 (on which a putative binding site was found by in-silico analysis) in tumor tissue from patients as compared cancer-free tissue. Relative were not be significantly altered patients. By...
Obesity is a multifactorial disease, associated with metabolic disorders and chronic low-grade inflammation. Procalcitonin (PCT) well known as biomarker of infection, systemic Recently, it has potential marker for inflammation.This study aims to evaluate the role serum PCT an inflammatory in diagnosis obesity-related inflammation.In this case-control study, 50 obese 35 normal weight children adolescents aged 5-15 years were enrolled. Anthropometric parameters measured all subjects. Blood...
The wound-healing process in diabetic foot is affected by pro and anti-inflammatory markers, any disruption the inflammatory reaction interferes with tissue homeostasis, leading to chronic non-wound healing. This study aimed determine diagnostic value effect of CRP, IL-6, TNF, HbA1c on initiation progression ulcers. ELISA was used quantify 205 patients diabetes, 105 were free. prevalence also evaluated. area under curve (AUC) calculated using receiver operating characteristic (ROC) analyze...
Background Colorectal cancer (CRC) is a type that thought to be influenced by human papillomaviruses (HPVs) and polyomaviruses (HPyVs). In Egypt, CRC ranks as the 7th most common cancer, accounting for 3.47% of male cancers 3% female cancers. However, there currently lack information regarding presence PyVs HPVs co-infection specifically in cases Egypt. Therefore, aim this study was investigate occurrence HPyVs (JCPyV, BKPyV, SV40) infections, well co-infections, among patients Additionally,...
Mesenchymal stem cells (MSCs) are considered to be a promising therapeutic protocol for diabetes mellitus (DM) management. The latter is attributed their differentiation potentiality pancreatic β-cells, angiogenesis, and immune-modulatory capabilities by releasing various paracrine factors. Interestingly, antioxidant co-administration increased the MSCs’ hypoglycemic regenerative activities. Thus, this study aims evaluate implication of type 1 DM after adipose tissue-derived-MSCs (AD-MSCs)...
Long non-coding RNAs (lncRNAs) have key roles in tumor development and the progress of many cancers, including breast cancer (BC). This study aimed to explore for first time association migration/differentiation-associated lncRNA SENCR rs12420823C/T variant with BC risk prognosis. Genotyping was carried out 203 participants (110 patients 93 controls) using TaqMan allelic discrimination technique. The corresponding clinicopathological data, recurrence/survival times, were analyzed different...
<b>Background:</b> The increasing occurrence of diabetes mellitus (DM) noted worldwide has considerably elicited concern in the recent past. DM is associated with elevated vascular complications, morbidity, mortality, and poor quality life. In this context, mesenchymal stem cells (MSCs) have shown significant therapeutic potentialities managing curing type 1 owing to their self-renewable, immunosuppressive, differentiation capacities. We investigated potential action N,...
Long non-coding RNAs (lncRNAs) are a class of RNA transcripts that long (i.e., more than 200 nucleotides) and not translated into proteins. They have recently emerged as potential treatment targets for numerous disorders due to their involvement in multiple cellular functions such gene regulation, epigenetic modulation, chromatin organization. This review highlights the current state lncRNA-based therapeutics, lncRNAs drug treating human diseases, various strategies types RNA-based...
Some anthropometric, laboratory, and genetic variations, such as patatin-like phospholipase domain-containing protein 3 (PNPLA3) variants, have been associated with nonalcoholic fatty liver disease (NAFLD). Liver biopsy is the most accurate NAFLD diagnostic method, but it invasive; hence, noninvasive diagnostics are required for early diagnosis assessment of NAFLD. This prospective case-control study included 107 patients healthy controls. All individuals underwent anthropometric...
Introduction Sophoridine, an alkaloid compound which is isolated from various plant species like Sophoraalopecuroides and Sophora flavescens. It identified to have potential pharmacological properties, including anti-inflammatory, anticancer antiviral activities. The effect of the sophoridine on mTOR NOTCH1 pathways that are critical in NSCLC not well understood. Materials Methods In order assess virtual interaction with sophoridine, we employed molecular docking. We also performed vitro...
Acanthamoeba spp. is a potentially pathogenic free-living amoeba (FLA) that causes central nervous system infections both in humans and animals significant cause of human keratitis, typically through contaminated water sources, soil contact lens solutions. The aim the study was to investigate contamination rate lenses (CL) their cleaning solutions with FLA, specific focus on as potential health threat Saudi Arabian wearers. A total 105 samples previously used were donated by female students...
B OTH hepatitis C virus and Helicobacter pylori infections are commonly found in Egypt.Correlation among HCV has been assisted.This work aim was to research H. DNA inside the liver tissue of Egyptian suffers with persistent find relation HP invasion HCV.This prospective study conducted 49 participants.Helicobacter Standard Kit (H.pylori) genome is designed for vitro H.pylori genomes from tissues patients chronic quantitatively.A TaqMan® principle used by primer probe.During PCR...
Background: Hepatocellular carcinoma (HCC) is the most well-known essential primary tumor of liver. It second leading cause cancer-related deaths worldwide, with a very poor prognosis. Early diagnosis and effective treatment HCC remain challenging in worldwide. If detected early, can be cured an excellent long-term frequently develops setting underlying chronic liver disease. Viral hepatitis (infection either C virus [HCV] or B [HBV]) thought to common etiology where estimated 78% global...
Environmental and genetic factors have a crucial role in the development progression of non-alcoholic fatty liver disease (NAFLD).The aim present study is to investigate association between single nucleotide polymorphism (SNP) rs738409 PNPLA3 gene rs1260326 GCKR NAFLD obese Egyptian population.Forty subjects (20 with 20 without NAFLD) control were enrolled this study.All genotyped for (rs738409) (rs1260326) polymorphisms using TaqMan assay.Results revealed that homozygous mutant GG genotype...
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has recently been considered as the most public problem worldwide and a major clinicopathologic health burden in developed countries. Biochemical tests are important verifying better understanding of many diseases hence help to have right decisions for achieving management.
 AIM: This study was conducted assess biochemical markers NAFLD Egyptian patients.
 METHODS: Forty obese subjects (32 females 8 males, mean age 42.32 ± 9.12...
Abstract Background Asthmatic bronchitis is a chronic allergic airway disease diagnosed after development of obstructive pulmonary symptoms. This study was designed to reveal relation the different electrophoretic patterns impairment lung functions in patients with asthmatic bronchitis. Materials and methods Patients were categorized into at mild stage ( n = 10) those severe 12) comparison healthy group 21). The major blood components, arterial gases electrolytes immediately assayed addition...
Background: PsA is a heterogeneous inflammatory arthritis. Patients (pts) with suffer from associated cardiovascular disease, obesity, metabolic syndrome, diabetes (DM), osteoporosis. In psoriasis, leptin has been shown to stimulate keratinocyte proliferation, expression of adhesion molecules and angiogenesis. Objectives: To detect the presence premature atherosclerosis in pts, measure HOMA-IR as reflection insulin resistance (IR) serum (LEP) level & their association pts. Methods: 45...
Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system and most common neurological in young adults, affecting more than 2.5 million people worldwide. The progression likely to be result neurodegeneration. Numerous therapies that have emerged treat relapsing forms MS been unsuccessful slowing or halting progressive disease, during which inflammatory activity replaced by axonal loss atrophy. BDNF-AS a type long non-coding RNAs has negative...