A5103134574- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Drug-Induced Hepatotoxicity and Protection
- Respiratory Support and Mechanisms
- Dupuytren's Contracture and Treatments
- Appendicitis Diagnosis and Management
- Rabies epidemiology and control
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects and Toxicity Studies
- Wound Healing and Treatments
- Thermal Regulation in Medicine
- Cell Adhesion Molecules Research
- Vector-borne infectious diseases
- Cutaneous lymphoproliferative disorders research
- Venous Thromboembolism Diagnosis and Management
- Pneumonia and Respiratory Infections
- SARS-CoV-2 detection and testing
- Pregnancy and Medication Impact
- Liver physiology and pathology
- Nuclear Receptors and Signaling
- Pancreatic function and diabetes
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
NHS Lothian
2024
Edinburgh Royal Infirmary
2024
Centre for Inflammation Research
2016-2021
The Queen's Medical Research Institute
2016-2021
University of Edinburgh
2014-2021
Dupuytren's disease (DD) is a common, progressive fibroproliferative affecting the palmar fascia of hands, causing fingers to irreversibly flex toward palm with significant loss function. Surgical treatments are limited; therefore, effective new therapies for DD urgently required. To identify key cellular and molecular pathways driving DD, we employed single-cell RNA sequencing, profiling transcriptomes 35,250 human single cells from nonpathogenic fascia, healthy dermis. We DD-specific...
The innate immune system is profoundly dysregulated in paracetamol (acetaminophen)-induced liver injury. neutrophil-lymphocyte ratio (NLR) a simple bedside index with prognostic value number of inflammatory conditions.To evaluate the accuracy NLR patients significant injury following single time-point and staggered overdoses.Time-course analysis 100 50 overdoses admitted to tertiary centre. Timed laboratory samples were correlated time elapsed after overdose or admission, respectively, was...
Back pain is a common symptom among patients presenting to the acute medical unit. We describe case of 55-year-old man with brief history fatigue and severe back pain, unresponsive escalating doses opiate analgesia. Blood tests imaging studies were unremarkable functional diagnosis was considered. Several weeks into his admission he developed lower motor neurone facial nerve palsy. He treated antibiotics for an incidental finding hospital-acquired pneumonia on imaging, which remarkably led...