A5054448286- Periodontal Regeneration and Treatments
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Sports injuries and prevention
- Total Knee Arthroplasty Outcomes
- Lower Extremity Biomechanics and Pathologies
- Shoulder and Clavicle Injuries
- Hip disorders and treatments
- Orthopedic Surgery and Rehabilitation
- Orthopaedic implants and arthroplasty
- Tissue Engineering and Regenerative Medicine
- Medicine and Dermatology Studies History
- Bone fractures and treatments
- Musculoskeletal Disorders and Rehabilitation
- Historical Studies in Science
- Paraoxonase enzyme and polymorphisms
- Enzyme function and inhibition
- Musicians’ Health and Performance
- Cardiac tumors and thrombi
- Hemostasis and retained surgical items
- Medical research and treatments
- Musculoskeletal synovial abnormalities and treatments
Hospital Quirónsalud Barcelona
2013-2023
Universitat de Barcelona
2021-2022
Universidad de Morelia
2022
National Institute of Science and Technology in Regenerative Medicine
2021
FC Barcelona
2014-2021
Unidad de Cirugía Artroscópica
2019
Universidad Cardenal Herrera CEU
2014-2018
Fundación Pablo García
2016
Center of Regenerative Medicine in Barcelona
2015
Background: The use of plasma rich in growth factors (PRGF) has been proposed to improve the healing Achilles tendon injuries, but there is debate about effectiveness this therapy. objective present study was evaluate histological effects PRGF, which a type leukocyte-poor platelet-rich plasma, on healing. Methods: tendons twenty-eight sheep were divided surgically. animals randomly into four groups seven each. repaired two received an infiltration PRGF intraoperatively and every week for...
Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). Spontaneous cartilage regeneration extremely limited. Often the treatment consists of a partial or complete implant. Adipose-derived stem cell (ASC) transplantation has been shown to restore degenerated cartilage; however, regenerative differences ASC would depend on source adipose tissue. The infra- suprapatellar fat pads surrounding knee offer potential autologous for patients...
Purpose: To compare the healing and clinical outcomes of anterior cruciate ligament (ACL) reconstruction between patients with or without intraoperative administration adipose-derived regenerative stem cells (ADRC). Methods: Between 2013 2014, 20 soccer players undergoing ACL using bone–patellar tendon–bone autograft infiltrated ADRC at end procedure were compared to a historical, matched cohort 19 same ADRC. Outcomes obtained baseline, 6 12 months postop for IKDC (International Knee...
Purpose: To report the clinical, functional, and magnetic resonance imaging (MRI)-based outcomes of a novel autologous-made matrix consisting hyaline cartilage chips combined with mixed plasma poor rich in platelets clot growth factors (PRGF) for treatment knee full-thickness or osteochondral defects. Methods: Between July 2015 January 2018, all patients defects undergoing this restoration surgical technique were approached eligibility. Indications procedure included traumatic atraumatic...
Adipose-derived stem cells (ASCs) are a promising therapeutic alternative for tissue repair in various clinical applications. However, restrictive cell survival, differential integration, and undirected differentiation after transplantation hostile microenvironment complications that require refinement. Plasma rich growth factors (PRGF) from platelet-rich plasma favors human canine ASC proliferation, delaying senescence autophagocytosis comparison with serum-containing cultures. In addition,...
The aim of this study was to evaluate changes in the enzymes creatine kinase (CK), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) saliva before after an intense exercise consisting a futsal match.CK, LDH AST were analyzed serum samples eleven, injury-free, amateur young men 30 minutes, 12 hours 36 match.A significant increase CK, observed game samples. In saliva, although high interindividual variability found with some individuals no showing increases, increases CK game....
We report a 44-year-old woman with calcific tendinitis of the shoulder treated platelet-rich plasma injection. Prior to this, she had no improvement symptoms after 6 weeks ultrasound treatment, Codman exercises, and anti-inflammatory treatment. Platelet-rich was injected into subacromial area 3 times at 2-week intervals. She progressive pain 2 weeks, asymptomatic week 6. The patient then underwent previous protocol rehabilitation. At one-year follow-up, pain-free complete resolution...
Although saliva has esterase activity, this activity not been characterized or studied in individuals subjected to physical stress. The aim of report was develop and validate an automated spectrophotometric assay for total measurement human saliva, as well study the contribution different enzymes on its behaviour under stress healthy subjects. used 4-nitrophenyl acetate substrate precise, accurate provided low limits detection quantification. Inhibition with diisopropylfluorophosphate showed...
Introduction: The cartilage injuries are related to femoroacetabular impingement (FAI). prognostic of the injury depends on grade itself. Using bone marrow concentrate (BMC), which contains stem cells, is improvement in diverse tissues. purpose this study was evaluate patients after a FAI arthroscopic intervention using BMC. We compared results those previous cohort who had identical surgery but without Methods: A conducted between 2015 and 2017. Forty with that underwent hip arthroscopy...
Knee cartilage or osteochondral lesions are common and challenging injuries. To date, most symptomatic warrant surgical treatment. We present two cases of patients with knee defects treated a one-step procedure consisting an autologous-based matrix composed healthy hyaline chips, mixed plasma poor-rich in platelets clot, rich growth factors (PRGF). Both returned to playing soccer at the preinjury activity level demonstrated excellent defect filling both magnetic resonance imaging second-look...
<h2>Abstract</h2> Articular hyaline cartilage injuries can occur as a result of either traumatic progressive degeneration. When the articular in joint is damaged, it cause pain and dysfunction, predisposing patients for development early-onset osteoarthritis. There are many restoration procedures available to treat these injuries, such bone marrow−stimulation techniques, osteoarticular auto/allograft transplants, autologous chondrocyte implantation. Each techniques has its own limitations,...
Osteoarticular pathologies very often require an implementation therapy to favor regeneration processes of bone, cartilage and/or tendons. Clinical approaches performed on osteoarticular complications in dogs constitute ideal model for human clinical translational applications. The adipose-derived mesenchymal stem cells (ASCs) have already been used accelerate and facilitate the regenerative process. ASCs can be maintained vitro they differentiated osteocytes or chondrocytes offering a good...
The aim of this study was to evaluate the use serum type II collagen cleavage epitope and hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs. For purpose, a model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich growth factors used. This clinical included 10 dogs hip osteoarthritis. Both analytes were measured at baseline, just before applying treatment, 1, 3, 6 months after treatment. These results compared those obtained force...
The treatment of chondral and osteochondral defects is challenging. These types lesions are painful progress to osteoarthritis over time. Tissue engineering offers tools address this unmet medical need. use an autologous cartilage construct consisting hyaline chips embedded in plasma rich growth factors (PRGF) has been proposed as a therapeutic alternative. purpose study was dig into the potential mechanisms behind vitro remodelling process that might explain clinical success technique...
Abstract Background Superior dislocation of the patella is an uncommon condition that mainly occurs in knees with a high and medial femorotibial degenerative arthritis. There are no previous reports this occurring association tibial valgus osteotomy. Case report: We report case patient whom vertical recurred twice at 4 months after To avert additional recurrence or new dislocations, was treated surgically to remove existing osteophytes. Conclusions: An arthroscopic approach decided because...
Degenerative joint disease, also known as osteoarthritis, is currently one of the most prevalent and morbid diseases due to an increase in both life expectancy obesity. Moreover, its severity irreversibility, osteoarthritis causes a severe social economic impact around world loss quality productivity. Osteoarthritis be multifactorial where several risk factors have been already described, leading temporary progressive structural changes within tissues, especially cartilage, subchondral bone,...