A5003688146- Neuroinflammation and Neurodegeneration Mechanisms
- Toxoplasma gondii Research Studies
- Inflammasome and immune disorders
- COVID-19 Impact on Reproduction
- Adolescent and Pediatric Healthcare
- Reproductive System and Pregnancy
- Neurogenesis and neuroplasticity mechanisms
- Cytomegalovirus and herpesvirus research
- RNA regulation and disease
- Quality and Supply Management
- Clostridium difficile and Clostridium perfringens research
- Ginseng Biological Effects and Applications
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Cerebral Palsy and Movement Disorders
- Immune cells in cancer
- Clusterin in disease pathology
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
University of Virginia
2016-2022
Abstract Microglia, resident immune cells of the CNS, are thought to defend against infections. Toxoplasma gondii is an opportunistic infection that can cause severe neurological disease. Here we report during T. a strong NF-κB and inflammatory cytokine transcriptional signature overrepresented in blood-derived macrophages versus microglia. Interestingly, IL-1α enriched microglia IL-1β macrophages. We find mice lacking IL-1R1 or IL-1α, but not IL-1β, have impaired parasite control cell...
Abstract Oligodendrocyte progenitor cells (OPCs) account for approximately 5% of the adult brain and have been historically studied their role in myelination. In brain, OPCs maintain proliferative capacity ability to differentiate into oligodendrocytes throughout adulthood, even though relatively few mature are produced post-developmental Recent work has begun demonstrate that likely perform multiple functions both homeostasis disease can significantly impact behavioral phenotypes such as...
Multiple sclerosis is a devastating neurological disorder characterized by the autoimmune destruction of central nervous system myelin. While T cells are known orchestrators immune response leading to MS pathology, precise contribution CNS resident and peripheral infiltrating myeloid less well described. Here, we explore cell function Low-density lipoprotein receptor-related protein-1 (LRP1), scavenger receptor involved in myelin clearance inflammatory response, context sclerosis. Supporting...
Abstract The gut microbiome is known to be sensitive changes in the immune system, especially during autoimmune diseases such as Multiple Sclerosis (MS). Our study examines that occur experimental encephalomyelitis (EAE), an animal model for MS. We collected fecal samples at key stages of EAE progression and quantified microbial abundances with 16S V3–V4 amplicon sequencing. analysis data suggests abundance commensal Lactobacillaceae decreases while other populations belonging...
Abstract White matter loss has been described as a common occurrence in Alzheimer’s disease (AD) patients for multiple decades. However, it remains unclear why oligodendrocyte progenitor cells (OPCs) fail to repair myelin deficits these patients. Here, we show that clusterin, risk factor late-onset AD, is produced by OPCs and inhibits their differentiation into oligodendrocytes. Specifically, demonstrate unique subset of produces clusterin. We phagocytosis debris, including amyloid beta (Aβ)...
Systemic maternal inflammation during pregnancy is increasingly thought to be a risk factor for development of autism spectrum disorder (ASD), which diagnosed at rate 4-fold higher in males than females. Administration the viral mimic polyI:C pregnant mice mid-gestation leads ASD-related phenotypes offspring, consisting deficits communication and socialization, as well repetitive behaviors. In this model immune activation (MIA), elevated production serum cytokines known promote alterations...
Abstract Systemic maternal inflammation during pregnancy is increasingly thought to be a risk factor for development of autism spectrum disorder (ASD), which diagnosed at rate 4-fold higher in males than females. Administration the viral mimic polyI:C pregnant mice mid-gestation leads an ASD-like phenotype offspring, consisting deficits socialization and communication as well repetitive behaviors. In this model immune activation (MIA), elevated production serum cytokines, specifically IL-6...
Abstract Microglia, the resident immune cells of brain parenchyma, are thought to be first-line defenders against CNS infections. We sought identify specific roles microglia in control eukaryotic parasite Toxoplasma gondii , an opportunistic infection that can cause severe neurological disease. In order function during infection, we sorted and infiltrating myeloid from infected reporter mice. Using RNA-sequencing, find strong NF- κ B inflammatory cytokine signatures overrepresented...