A5021433125- Neurobiology of Language and Bilingualism
- Hearing Impairment and Communication
- Action Observation and Synchronization
- Face Recognition and Perception
- Tactile and Sensory Interactions
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Hand Gesture Recognition Systems
- Language, Metaphor, and Cognition
- Multisensory perception and integration
- Bipolar Disorder and Treatment
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Health and Well-being Studies
- Motor Control and Adaptation
- Categorization, perception, and language
- Reading and Literacy Development
- Language, Discourse, Communication Strategies
- Memory Processes and Influences
- Visual perception and processing mechanisms
- Cognitive Computing and Networks
- Language Development and Disorders
- Neuroscience and Neuropharmacology Research
San Diego State University
2013-2019
University of California, San Diego
2018
National Institutes of Health
2005-2012
Georgetown University
2011
Georgetown University Medical Center
2011
National Institute of Mental Health
1997-2006
Motivated by neuropsychological investigations of category-specific impairments, many functional brain imaging studies have found distinct patterns neural activity associated with different object categories. However, the extent to which these category-related activation reflect differences in conceptual representation remains controversial. To investigate this issue, magnetic resonance (fMRI) was used record changes while subjects interpreted animated vignettes composed simple geometric...
Does our ability to visually identify everyday objects rely solely on access information about their appearance or a more distributed representation incorporating other object properties? Using functional magnetic resonance imaging, we addressed this question by having subjects match pictures of novel before and after extensive training use these perform specific tool-like tasks. After training, neural activity emerged in regions associated with the motion (left middle temporal gyrus)...
Abstract We used rapid, event-related fMRI to identify the neural systems underlying object semantics. During scanning, subjects silently read rapidly presented word pairs (150 msec, SOA = 250 msec) that were either unrelated in meaning (ankle-carrot), semantically related (fork-cup), or identical (crow-crow). Activity left posterior region of fusiform gyrus and inferior frontal cortex was modulated by word-pair relationship. Semantically yielded less activity than pairs, but greater...
Clinically, the hallmark of human amnesic syndrome is an impaired ability to consciously recollect or remember daily events. If medial region temporal lobes, including hippocampus and related structures, critical for establishing these new memories, then this brain should be active whenever events are experienced, regardless whether subjects asked explicitly learn remember. Here we show that during encoding hemisphere activated amount activation depend on type stimulus presented (objects...
Studies of autism spectrum disorders (ASDs) reveal dysfunction in the neural systems mediating object processing (particularly faces) and social cognition, but few investigations have systematically assessed specificity dysfunction. We compared cortical responses typically developing adolescents those with ASD to stimuli from distinct conceptual domains known elicit category-related activity separate systems. In Experiment 1, subjects made category decisions photographs, videos, point-light...
ABSTRACT Previous reports suggest that repetition priming (i.e., enhanced processing of a stimulus after experience with stimulus) is long lasting and impervious to the effects age, in contrast pattern found explicit memory. However, nature aged individuals remains unclear, as conflicting findings have also been reported. We used longitudinal design examine how affected by multiple repetitions (three presentations) different delay intervals (no delay, 1 day, week, month) young adults, well...
We used functional magnetic resonance imaging to identify the neural regions that support comprehension of fingerspelled words, printed and American Sign Language (ASL) signs in deaf ASL–English bilinguals. Participants made semantic judgements (concrete–abstract?) each lexical type, hearing non-signers served as controls. All three types engaged a left frontotemporal circuit associated with processing. Both words activated visual word form area for signers only. Fingerspelled were more...
To examine whether more ecologically valid co-speech gesture stimuli elicit brain responses consistent with those found by studies that relied on scripted stimuli, we presented participants spontaneously produced, meaningful during fMRI scanning (n = 28). Speech (vs. either alone) elicited heightened activity in bilateral posterior superior temporal, premotor, and inferior frontal regions. Within left temporal but not regions, identified small clusters superadditive responses, suggesting...
Abstract Previous work indicates that 1) adults with native sign language experience produce more manual co-speech gestures than monolingual non-signers, and 2) one year of ASL instruction increases gesture production in adults, but not enough to differentiate them from non-signers. To elucidate these effects, we asked early ASL–English bilinguals, fluent late second (L2) signers (≥ 10 years signing), non-signers retell a story depicted cartoon clips partner. Early L2 produced at higher...