A5087227094- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA Research and Splicing
- RNA modifications and cancer
- RNA regulation and disease
- Animal Genetics and Reproduction
- Cancer Immunotherapy and Biomarkers
- Identification and Quantification in Food
- Immune cells in cancer
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Genetic and phenotypic traits in livestock
- Forensic and Genetic Research
- Cancer-related gene regulation
Children's Hospital of Fudan University
2021-2025
Institute of Special Animal and Plant Sciences
2022
Wuhan University
2021
Abstract Sex reversal, representing extraordinary sexual plasticity during the life cycle, not only triggers reproduction in animals but also affects reproductive and endocrine system-related diseases cancers humans. reversal has been broadly reported animals; however, an integrated resource hub of sex information is still lacking. Here, we constructed a comprehensive database named ASER (Animal Reversal) by integrating reversal-related data 18 species from teleostei to mammalia. We...
Abstract Sex reversal, representing extraordinary sexual plasticity during the life cycle, not only triggers reproduction in animals but also affects reproductive and endocrine system-related diseases cancers humans. reversal has been broadly reported animals, however, an integrated resource hub of sex information is still lacking. Here, we constructed a comprehensive database named ASER by integrating reversal-related data 18 species from Teleostei to Mammals. We systematically collected...
Effective cancer immunotherapy relies on enhancing the host's immune response, particularly by boosting T cell-mediated cytotoxicity against tumor cells. In this study, we identify CWF19-like cell cycle control factor 1 (CWF19L1) as a novel splicing regulator that enhances cytotoxicity. CWF19L1 interacts prominently with key factors within nucleus, including components of U5 small nuclear ribonucleoprotein and pre-mRNA processing 19 (PRPF19) complex. Deficiency disrupts alternative...
RNA splicing is a crucial posttranscriptional process that governs gene expression, and defects in alternative contribute to various diseases, including cancer. Tumor suppressing subtransferable candidate 4 (TSSC4) known tumor suppressor has been identified as part of the U5 small nuclear ribonucleoprotein (snRNP), which involved tri-snRNP biogenesis. However, precise role TSSC4 regulating its impact on growth remain unclear.
Ethnopharmacological relevance: Hard antler extract, a well-known traditional Chinese medicine, has diversified functions of immune-modulatory, anti-oxidation, anti-inflammatory and anti-stress. However, the effect HAE on hormone receptor-positive breast cancer not been studied.Aim study: To investigate anti-tumor effects hard extract MCF-7 cells 7,12 dimethylbenz (a) anthracene (DMBA)-induced mammary tumors to explore its potential mechanism.Methods: We tested prepared by sequential...