A5021460411- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- HIV Research and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autoimmune Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Peripheral Neuropathies and Disorders
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Amyotrophic Lateral Sclerosis Research
- Full-Duplex Wireless Communications
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Olfactory and Sensory Function Studies
- CNS Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- COVID-19 and healthcare impacts
- Immunodeficiency and Autoimmune Disorders
- HIV-related health complications and treatments
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- HIV/AIDS Research and Interventions
- Tryptophan and brain disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University of Washington
2016-2025
Fred Hutch Cancer Center
2024
Northwestern University
2024
Presbyterian St. Luke's Medical Center
2024
Colorado Blood Cancer Institute
2024
University of Colorado Anschutz Medical Campus
2024
VA Puget Sound Health Care System
2022
Memorial University of Newfoundland
2021
Tidewater Community College
2018
Multiple Sclerosis Center Of Northeastern New York
2018
Human endogenous retrovirus-K is activated in the cortical neurons of patients with amyotrophic lateral sclerosis, and expression viral envelope protein mouse brain reproduces clinical pathological phenotype this disease.
BACKGROUND Brentuximab vedotin (BV) is an anti‐CD30 monoclonal antibody‐drug conjugate that was approved in 2011 for the treatment of patients with anaplastic large cell and Hodgkin lymphomas. The product label indicates 3 who were treated BV developed progressive multifocal leukoencephalopathy (PML), a frequently fatal JC virus‐induced central nervous system infection. Prior immunosuppressive therapy compromised immune systems postulated risk factors. In current study, authors reported 5...
<b>Objective:</b> Natalizumab is a humanized recombinant monoclonal antibody against very late activation antigen-4 approved for the treatment of patients with multiple sclerosis (MS). A phase II study failed to demonstrate difference between natalizumab groups and placebo group regard gadolinium enhancing lesions on MRI 3 months after discontinuation therapy. The objective this was assess clinical MS disease activity, surrogate markers MRI, immunologic parameters in peripheral blood CSF, as...
Progressive multifocal leukoencephalopathy (PML), caused by JC virus (JCV), can occur in patients receiving natalizumab for multiple sclerosis (MS). JCV detection quantitative polymerase chain reaction (qPCR) cerebrospinal fluid (CSF), or brain biopsy, is required probable definite diagnosis of PML. However, some only low levels DNA (<100 copies/ml) are present CSF, making the challenging. Our objective was to assess complementary value a CSF antibody index (AIJCV ) natalizumab-associated...
Background: Natalizumab for multiple sclerosis (MS) increases the risk of progressive multifocal leukoencephalopathy (PML). Objective: We aimed to assess effect natalizumab on cellular composition and functional B cell parameters including patients with natalizumab-associated PML ( n=37). Methods: Cellular by flow cytometry, levels immunoglobulin (Ig)G/IgM immunonephelometry, oligoclonal bands isoelectric focusing were studied in blood cerebrospinal fluid. Results: In MS treated without...
To describe a case of glycine receptor (GlyR) antibody-positive stiff person syndrome (SPS) treated with autologous hematopoietic stem cell transplant (aHSCT).
Dietary factors have been discussed to influence risk or disease course of multiple sclerosis (MS). Specific diets are widely used among patients with MS.To design and pilot-test an evidence based patient education program on dietary in MS.We performed a systematic literature search the effectiveness interventions MS. A web-based survey 337 MS 136 healthy controls assessed knowledge, habits information needs. An interactive group was developed pilot-tested.Fifteen randomised-controlled...
A 38-year-old woman was diagnosed with cutaneous anaplastic T-cell lymphoma that proved refractory to methotrexate, bexarotene, denileukin diftitox, interferon γ-1b, α-2b, vorinostat, and pralatrexate. She therefore started on the newly approved monoclonal anti-CD30 antibody brentuximab vedotin. Treatment 1.8 mg/kg IV every 3 weeks quickly led disappearance of her tumors. The day after second infusion she developed word-finding difficulties unsteady gait. Due further neurologic...
Proinflammatory factors from activated T cells inhibit neurogenesis in adult animal brain and cultured human fetal neural stem (NSC). However, the role of inhibition neuroinflammatory diseases is still uncertain because difficulty obtaining NSC patients. Recent developments cell reprogramming suggest that may be derived directly fibroblasts. We generated peripheral CD34+ by transfecting with Sendai virus constructs containing Sox2, Oct3/4, c-Myc Klf4. The could differentiated to glial action...
The ability to tolerate uncertainty about the future may be foundational positive psychological adjustment. Conversely, intolerance of (IU) has been shown a vulnerability factor for anxiety and depression. One stressor with very high degree is new diagnosis multiple sclerosis (MS). However, few interventions in MS have directly targeted IU. Research Method/Design: Forty-eight participants early moderate levels distress were randomized receive either 6 sessions brief intervention designed...
Human immunodeficiency virus (HIV) infection of the central nervous system (CNS) is frequently associated with intrathecal immunoglobulin synthesis and cerebrospinal fluid (CSF) pleocytosis, but little known about B-cell response in CSF these patients. In this study, we investigated relation between load frequency phenotype B cells HIV-infected patients.The distribution T cells, short-lived plasmablasts, long-lived plasma was analyzed by flow cytometry peripheral blood 33 patients HIV...
A valid, sensitive patient-reported outcome (PRO) measure of physical function (PF) for people with multiple sclerosis (MS) would have substantial value in routine care and clinical research. We now describe development the PROMISnq Short Form v2.0 PF - Multiple Sclerosis 15a [PROMISnq PF(MS)15a] assessing relapsing progressive MS. Also, validity, reliability, responsiveness PF(MS)15a is evaluated, minimal important difference (MID) thresholds score change estimated a interpretation guide...
Fingolimod is a daily oral medication used to treat relapsing multiple sclerosis (MS). Clinicians often adopt less frequent dosing for patients with profound drug-induced lymphopenia or other adverse events. Data on the effectiveness of alternate dose fingolimod are limited.We conducted multicenter, retrospective, observational study at 14 sites and identified 170 MS taking doses ≥1 month. Clinical radiologic outcomes were collected compared during dosing.Profound (77%), liver function...
Project ECHO (Extension for Community Healthcare Outcomes) represents a novel approach to addressing disparities in multiple sclerosis (MS) care. A primary mechanism of the program is use case consultations rapidly transfer knowledge from content experts community providers who care individuals with MS.MS was pilot tested as weekly 60-minute videoconference delivered 24 clinicians across 13 practice sites over 41 weeks. Participants completed variety measures related their experience and...
This summary describes how researchers worked with people multiple sclerosis (MS), neurologists and measurement experts to create an easy-to-use questionnaire measure the physical function of MS. covers topics that are relevant important MS their doctors.The ability do what you want do, when it, is one most concerns for could help doctors record manage much affects people's lives.MS can bring a range challenging symptoms such as '
Stiff person syndrome (SPS) is a rare and disabling neurological disease characterized by progressive stiffness of skeletal muscles, rigidity episodic painful muscle spasms, resulting in severely impaired volitional movements ambulation some patients (pts). Electromyography (EMG) typically shows continuous motor activity. 60% -80% affected pts have autoantibodies against glutamic acid decarboxyloase (GAD), key enzyme for maintaining inhibitory CNS pathways. SPS considered an autoimmune...