A5062898550- HIV, Drug Use, Sexual Risk
- Opioid Use Disorder Treatment
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Circadian rhythm and melatonin
- Psychological and Temporal Perspectives Research
- RNA regulation and disease
- Sex work and related issues
- Prion Diseases and Protein Misfolding
- Sleep and related disorders
- RNA Research and Splicing
- Behavioral Health and Interventions
- Prenatal Substance Exposure Effects
Yale University
2021-2025
National Heart Lung and Blood Institute
2023
National Institutes of Health
2023
Colgate University
2017-2018
Generalized anxiety and major depression have become increasingly common in the United States, affecting 18.6 percent of adult population. Mood disorders can be debilitating, are often correlated with poor general health, life dissatisfaction, need for disability benefits due to inability work. Recent evidence suggests that some mood a circadian component, disruptions rhythms may even trigger development these disorders. However, molecular mechanisms this interaction not well understood....
Anxiety and other mood disorders, such as major depressive disorder (MDD) seasonal affective (SAD), affect nearly one-fifth of the global population disproportionately young adults. Individuals affected by disorders are frequently plagued sleep circadian problems, recent genetic studies provide ample support for association syndromes with depression anxiety. Mathematical modeling has been crucial in understanding some essential features mammalian clock is now a vital tool dissecting how...
The Sup35 prion protein of budding yeast has been reported to undergo phase separation form liquid droplets both at low pH in vitro and when energy depletion decreases the intracellular vivo. It also shown using purified proteins that this is driven by domain does not re-quire its C-terminal domain. In contrast, we now find a fragment consisting only N-terminal M-domain separate vivo; requires domain, which binds Sup45 translation termination complex. phase-separated colocalizes with but...
HIV incidence and mortality are increasing in Eastern Europe Central Asia concentrated people who inject drugs. Maintenance with opioid agonist therapies (OAT) like methadone or buprenorphine is the best treatment for use disorder a key HIV-prevention strategy region. In Kazakhstan, scale-up of has been minimal since methadone's introduction 2008 supported through international charitable organizations. As Republic Kazakhstan designated to assume financial administrative oversight OAT,...
HIV incidence continues to increase in Eastern Europe and Central Asia (EECA), large part due non-sterile injection drug use, especially within prisons. Therefore, medication-assisted therapy with opioid agonists is an evidence-based HIV-prevention strategy. The Kyrgyz Republic offers methadone its prison system, but uptake remains low. Screening, Brief Intervention, Referral Treatment (SBIRT) a framework for identifying people who would potentially benefit from methadone, intervening...
Background People in criminal justice settings (CJS) have high rates of opioid use disorder (OUD) and HIV. Probation is part the CJS congregates many individuals with mental health substance disorders relative to general population; nevertheless, probation remains a major improvement incarceration. As steppingstone full decarceration efforts, community supervision like can be leveraged as “touchpoints” identify link people OUD (and other co-morbid conditions) treatment reduce activity....
The incidence and mortality of human immunodeficiency viruses (HIVs) are rising in Eastern Europe Central Asia (EECA), particularly among people who inject drugs. Opioid agonist therapies (OATs), such as methadone or buprenorphine, the most effective treatments for opioid use disorder serve a key HIV-prevention strategy EECA. OAT uptake across region, however, has been limited. Kyrgyz Republic was first Asian country to initiate remains pioneer region. To understand progression scale-up, all...