A5102721905- Microbial Inactivation Methods
- Cutaneous Melanoma Detection and Management
- Toxin Mechanisms and Immunotoxins
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Transgenic Plants and Applications
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Pancreatic and Hepatic Oncology Research
- Skin Protection and Aging
- Colorectal Cancer Surgical Treatments
- Clinical Nutrition and Gastroenterology
- Child Nutrition and Feeding Issues
- Corneal Surgery and Treatments
- Surgical Sutures and Adhesives
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Surgical site infection prevention
- Reconstructive Surgery and Microvascular Techniques
- Stoma care and complications
- Colorectal and Anal Carcinomas
- Urinary and Genital Oncology Studies
- Pulsed Power Technology Applications
- Plasma Applications and Diagnostics
- Brain Metastases and Treatment
University of Vermont Medical Center
2017-2025
Duke Medical Center
2024
University of Louisville
2019-2022
Rice Institute
2022
Belfast Health and Social Care Trust
2020-2021
University of Kentucky
2020-2021
University of Vermont
2014-2017
The Honourable Society of Lincoln's Inn
1988
Cultures of human epidermal keratinocytes provide a useful experimental model with which to study the factors that regulate cell proliferation and terminal differentiation. One situation is known trigger premature differentiation suspension culture, when are deprived substratum intercellular contact. We have now investigated whether area contact, hence shape, can Keratinocytes were grown on circular adhesive islands prevented cell-cell By varying island we could vary shape from fully spread...
There is debate regarding the appropriate use of transanal endoscopic microsurgery for rectal cancer.This study analyzed our single-center experience with early cancer.Medical charts patients who underwent were reviewed to determine lesion characteristics, as well operative and treatment characteristics. Complications recurrences recorded.The was conducted at a single academic medical center.Patients stage cancer (T1 or T2, N0, M0) rectum included.Local overall recurrence disease-specific...
Introduction: Porocarcinoma (PC) is an uncommon, aggressive malignancy of the sweat gland apparatus characterized by diverse clinical presentation and challenging histopathology. Patients diagnosed with PC face a grim prognosis due to high rates recurrence metastasis. Case Report: We present case vulvar porocarcinoma initially managed surgical excisions, achieving clear margins. Subsequent surveillance revealed regional lymph node metastasis, prompting dissection. Discussion: Here, we...
Acquired resistance to cyclin-dependent kinases 4 and 6 (CDK4/6) inhibition in estrogen receptor-positive (ER+) breast cancer remains a significant clinical challenge. Efforts uncover the mechanisms underlying are needed establish clinically actionable targets effective against resistant tumors. In this study, we sought identify differentially expressed genes (DEGs) associated with acquired palbociclib ER+ cancer. We performed next-generation transcriptomic RNA sequencing (RNA-seq) pathway...
Abstract Purpose The management of triple-negative breast cancer (TNBC) remains a significant clinical challenge due to the lack effective targeted therapies. Inhibitors cyclin-dependent kinases 4 and 6 (CDK4/6) are emerging as promising therapeutic agents against TNBC; however, cells can rapidly acquire resistance through multiple mechanisms that yet be identified. Therefore, determining underlying CDK4/6 inhibition is crucial develop combination therapies extend efficacy inhibitors or...
Abstract Introduction Surgical site infections (SSIs) lead to increased morbidity and cost. Negative‐pressure wound therapy (NPWT) removes exudate improves local blood flow, but its effect on SSI is unproven following hepatectomy pancreatectomy. The aim of this trial was evaluate the NPWT in population. Methods Patients were randomized incisional or sterile island dressing surgery. predictive factors recorded as well patient comorbidities. Wound complications type prospectively. Results...
Talimogene laherparepvec (T-VEC) is currently the only United States Food and Drug Administration-approved intralesional therapy for advanced melanoma. Recent studies have assessed integration of T-VEC with systemic immunotherapy, though response remains variable. Therefore, we sought to identify factors associated by conducting a retrospective, single-center analysis involving melanoma patients treated T-VEC. In present study, recorded demographic clinicopathological data, details...
<h3>Introduction</h3> The emergence of checkpoint inhibitor immunotherapy (IO) has revolutionised outcomes for patients with metastatic melanoma, significantly improved response rates and survival shown in clinical trials. This treatment modality is however associated unique toxicities including hepatotoxicity. We aimed to determine if the hepatotoxicity our routine practice were comparable those existing literature. <h3>Methods</h3> Patients receiving combination IO (Ipilimumab Nivolumab)...
End organ disease is associated with sarcopenia and overall poor conditioning malnutrition.As such, nutritional support a critical component of post transplant recovery.Yet it multiple morbidities also significant mortality.Morbidities can occur as result efforts to deliver sustenance aspiration leading pulmonary infectious complications.Moreover, technical misadventures have been peritonitis secondary perforation, leaks malpositioning percutaneously placed feeding tubes.Herein we describe...
A 61-year-old woman with tobacco abuse presented after screening computed tomography scans demonstrated an incidental large pancreatic body cyst mural calcifications (Figure A). FNA showed macrophages and debris elevated CEA level. mucinous cystic neoplasm was therefore presumed. distal pancreatectomy splenectomy specimen 11.2 × 8.0 7.8-cm unilocular yellow viscous fluid, a tan lining, 0.3- to 0.7-cm-thick rubbery wall B). Histologically, the lining mostly denuded residual benign simple...