A5008455526- Lymphatic System and Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Metabolism, Diabetes, and Cancer
- Axon Guidance and Neuronal Signaling
- Angiogenesis and VEGF in Cancer
- Biomarkers in Disease Mechanisms
- T-cell and B-cell Immunology
- Lipid metabolism and disorders
- Hippo pathway signaling and YAP/TAZ
Uppsala University
2021-2025
Lipoprotein lipase (LPL) and multiple regulators of LPL activity (e.g., APOC2 ANGPTL4) are present in all vertebrates, but GPIHBP1-the endothelial cell (EC) protein that captures within the subendothelial spaces transports it to its site action capillary lumen-is mammals not chickens or other lower vertebrates. In mammals, GPIHBP1 deficiency causes severe hypertriglyceridemia, maintain low triglyceride levels despite absence GPIHBP1. To understand intravascular lipolysis we examined...
Lymphangiogenesis is the formation of lymphatic vessels from pre-existing vessels, a dynamic process that requires cell migration. Regardless location, endothelial (LEC) progenitors probe their surroundings while migrating to form network. Lymphatic development regulation depends on transcription factor MAFB in different species. Zebrafish Mafba, expressed LEC progenitors, essential for migration trunk. However, transcriptional mechanism orchestrate beds remains elusive. Here, we uncover...