A5047569887- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Neural dynamics and brain function
- Ion Channels and Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Laser Applications in Dentistry and Medicine
- Inflammasome and immune disorders
- RNA regulation and disease
- Immune Response and Inflammation
- Genetics and Neurodevelopmental Disorders
- Acoustic Wave Phenomena Research
- Antimicrobial Peptides and Activities
- S100 Proteins and Annexins
- RNA Research and Splicing
- Biochemical Analysis and Sensing Techniques
- Child Development and Digital Technology
Medical University of South Carolina
2016-2023
Age-related hearing loss, or presbyacusis, is a common degenerative disorder affecting communication and quality of life for millions older adults. Multiple pathophysiologic manifestations, along with many cellular molecular alterations, have been linked to presbyacusis; however, the initial events causal factors not clearly established. Comparisons transcriptome in lateral wall (LW) other cochlear regions mouse model (of both sexes) “normal” age-related loss revealed that early...
Age-related hearing loss is a chronic degenerative disorder affecting one in two individuals above the age of 75. Current population projections predict steady climb number older making search for interventions to prevent or reverse this even more critical. There growing acceptance that aberrant activity resident infiltrating immune cells, such as macrophages, major factor contributing onset and progression age-related diseases. However, how macrophage populations their functionally-driven...
Noise exposure causes auditory nerve (AN) degeneration and hearing deficiency, though the proximal biological consequences are not entirely understood. Most AN fibers spiral ganglion neurons ensheathed by myelinating glia that provide insulation ensure rapid transmission of impulses from cochlea to brain. Here we show noise administered mice either sex rapidly affects glial cells, causing molecular cellular precede degeneration. This response is characterized demyelination, inflammation,...
Hearing relies on the transmission of auditory information from sensory hair cells (HCs) to brain through nerve. This relay requires HCs be innervated by spiral ganglion neurons (SGNs) in an exclusive manner and SGNs ensheathed myelinating non-myelinating glial cells. In developing nerve, mistargeted SGN axons are retracted or pruned excessive cleared a process referred as nerve refinement. Whether eliminated during refinement is unknown. Using early postnatal mice either sex, we show that...
The peripheral auditory nerve (AN) carries sound information from sensory hair cells to the brain. present study investigated contribution of mouse and human hematopoietic stem (HSCs) cellular diversity in AN following destruction neuron cell bodies, also known as spiral ganglion neurons (SGNs). Exposure adult cochlea ouabain selectively killed type I SGNs disrupted blood-labyrinth barrier. This procedure resulted upregulation genes associated with homing differentiation, provided an...
Dysfunction of the peripheral auditory nerve (AN) contributes to dynamic changes throughout central system, resulting in abnormal processing, including hypersensitivity. Altered sound sensitivity is frequently observed autism spectrum disorder (ASD), suggesting that AN deficits and information processing may contribute ASD-associated symptoms, social communication hyperacusis. The MEF2C transcription factor associated with risk for several neurodevelopmental disorders, mutations or deletions...
Abstract The auditory nerve (AN) of the inner ear is primary conveyor acoustic information from sensory hair cells to brainstem. Approximately 95% peripheral AN fibers are myelinated by glial cells. integrity myelin and glial‐associated paranodal structures at node Ranvier critical for normal activity axonal survival function in central nervous system. However, little known about Ranvier's spatiotemporal development AN, how aging process (or injury) affects myelinating cells, downstream...
Exposure to noise or ototoxic agents can result in degeneration of cells the sensory epithelium and auditory nerve, as well non-sensory cochlear lateral wall. However, molecular mechanisms underlying this pathology remain unclear. The purpose study was localize identify proteins cochlea that are responsive exposure using a complementary proteo-transcriptomic approach. MALDI imaging sections revealed numerous protein signals with distinct localization patterns both injury models, which six...
Abstract Aging is associated with auditory nerve (AN) functional deficits and decreased inhibition in the central system, amplifying responses a process known as gain. Although gain enhances response amplitudes, may not restore disrupted timing. In this translational study, we measured from AN midbrain younger older mice humans. We hypothesized that humans exhibit without an improvement inter-trial synchrony midbrain. Our data demonstrated greater age-related amplitudes than shown by...
Abstract Dysfunction of the peripheral auditory nerve (AN) contributes to dynamic changes throughout central system, resulting in abnormal processing, including hypersensitivity. Altered sound sensitivity is frequently observed autism spectrum disorder (ASD), suggesting that AN deficits and information processing may contribute ASD-associated symptoms, social communication hyperacusis. The MEF2C transcription factor associated with risk for several neurodevelopmental disorders, mutations or...
Age-related hearing loss, or presbyacusis, is a common degenerative disorder affecting communication and quality of life for millions older adults. Multiple pathophysiologic manifestations, along with many cellular molecular alterations, have been linked to however, the initial events causal factors not clearly established. Comparisons transcriptome in lateral wall other cochlear regions mouse model “normal” age-related loss revealed that early pathophysiological alterations stria vascularis...
Abstract Glial cells of the auditory nerve regulate formation nodes Ranvier that are needed for regeneration action potentials and proper hearing function. Here we identify describe distinct features two novel types nodes—the axonal node ganglion node—in mouse change across lifespan, including during myelination postnatal development, degenerate aging. Cellular, molecular, structure-function correlation evaluations revealed nodal critical different aspects Specifically, length is associated...