A5101679698- Epigenetics and DNA Methylation
- RNA modifications and cancer
- RNA Research and Splicing
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Genomics and Chromatin Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related gene regulation
- Blood disorders and treatments
- Cancer-related molecular mechanisms research
- Health, Medicine and Society
- Genetics and Neurodevelopmental Disorders
- Erythrocyte Function and Pathophysiology
- Histone Deacetylase Inhibitors Research
- Pluripotent Stem Cells Research
- Cholesterol and Lipid Metabolism
- Blood groups and transfusion
- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- Social Sciences and Governance
- French Language Learning Methods
- Tissue Engineering and Regenerative Medicine
- Pomegranate: compositions and health benefits
- RNA regulation and disease
- Lipid Membrane Structure and Behavior
Université de Sherbrooke
2019-2025
Centre Hospitalier Universitaire de Sherbrooke
2021-2025
Active Aging Canada
2024
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2020-2024
Centre Hospitalier Le Vinatier
2022
Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean
2020-2021
Boston Children's Hospital
2013-2019
Harvard University
2013-2019
Centre Hospitalier Universitaire de Saint-Étienne
2001-2019
Hôpital Nord
2011-2019
Histone demethylation is known to regulate transcription, but its role in other processes largely unknown. We report a for the histone demethylase LSD1/KDM1A DNA damage response (DDR). show that LSD1 recruited directly sites of damage. H3K4 dimethylation, major substrate LSD1, reduced at an LSD1-dependent manner. The E3 ubiquitin ligase RNF168 physically interacts with and we find this interaction be important recruitment sites. Although loss did not affect initial formation pH2A.X foci,...
Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of from mouse forebrain at embryonic days E8.5 vs. E10.5 (before after neural tube closure). Genes encoding protein biosynthetic machinery were strongly downregulated E10.5. This was matched by decreases ribosome biogenesis and synthesis, together with age-related proteomic content adjacent fluids. Notably,...
RUNX1–RUNX1T1 (formerly AML1-ETO), a transcription factor generated by the t(8;21) translocation in acute myeloid leukemia (AML), dictates leukemic program increasing self-renewal and inhibiting differentiation. Here we demonstrate that histone demethylase JMJD1C functions as coactivator for is required its transcriptional program. directly recruited to target genes regulates their expression maintaining low H3K9 dimethyl (H3K9me2) levels. Analyses knockout mice also establish requirement...
Mutations in KDM5C are an important cause of X-linked intellectual disability males. encodes a histone demethylase, suggesting that alterations chromatin landscape may contribute to disease. We used primary patient cells and biochemical approaches investigate the effects mutations on expression, stability catalytic activity. report characterize novel nonsense mutation, c.3223delG (p.V1075Yfs*2), which leads loss protein. also two missense mutations, c.1439C>T (p.P480L) c.1204G>T (p.D402Y)...
Alzheimer's disease (AD) is the most common neurodegenerative ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, role of neuroinflammation related to systemic inflammation still unsettled. While implication microglia well recognized, exact contribution peripheral monocytes/macrophages largely unknown, especially concerning their in various stages AD.AD develops over decades its manifestation preceded by subjective memory complaints (SMC)...
During aging, changes in gene expression are associated with a decline physical and cognitive abilities. Here, we investigate the connection between mRNA protein brain by comparing transcriptome proteome of mouse cortex during aging. Our transcriptomic analysis revealed that aging mainly triggers activation cortex. We showed an increase correlates expression, specifically anterior cingulate cortex, where also observed cortical thickness Genes exhibiting aging-dependent levels involved...
The RNA-binding protein Musashi-1 (MSI1) exerts essential roles in multiple cellular functions, such as maintenance of self-renewal and pluripotency stem cells. MSI1 overexpression has been observed several tumor tissues, including glioblastoma (GBM), is considered a well-established marker for metastasis recurrence. However, the molecular mechanisms by which regulates cell migration are still undetermined. Here we reported that alters morphology, promotes migration, increases...
ABSTRACT Genes involved in the regulation of chromatin structure are frequently disrupted cancer, contributing to an aberrant transcriptome and phenotypic plasticity. Yet, therapeutics targeting mutant forms chromatin-modifying enzymes have yielded only modest clinical utility, underscoring difficulty epigenomic underpinnings gene regulatory networks. Here, we sought identify novel epigenetic vulnerabilities diffuse large B-cell lymphoma (DLBCL). Through screens biochemical analysis,...
Background Alzheimer's disease (AD) is a chronic brain degenerative that leads to dementia. Objective The aim of the present study investigate neuroprotective impact sodium-glucose cotransporter-2 inhibitors (SGLT2i) (empagliflozin and dapagliflozin) on tau phosphorylation, oxidative stress, neuroinflammation. Methods We used MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay, annexin-V-FITC kit, DCFH-DA (dichloro-dihydro-fluorescein diacetate) respectively evaluate...
Gfi-1B is a transcriptional repressor essential for the regulation of erythropoiesis and megakaryopoiesis. Here we identify p32, isoform, as erythroid differentiation. p32 generated by alternative splicing lacks two first zinc finger domains protein. Selective knock down compromises differentiation, whereas its ectopic expression induces in absence erythropoietin. isoform binds to target gene promoters associates with LSD1–CoREST complex more efficiently than major p37 isoform. Furthermore,...
Oxidative stress and chronic inflammation, at both the systemic central level, are critical early events in atherosclerosis Alzheimer's disease (AD).
Pluripotency and cell fates can be modulated through the regulation of super-enhancers; however, underlying mechanisms are unclear. Here, we showed a novel mechanism in which Ash2l directly binds to super-enhancers several stemness genes regulate pluripotency self-renewal pluripotent stem cells. recruits Oct4/Sox2/Nanog (OSN) form Ash2l/OSN complex at Jarid2, Nanog, Sox2 Oct4, further drives enhancer activation, upregulation genes, maintains circuitry. knockdown abrogates OSN recruitment all...