Login

Marleen Mayer

ORCID: 0000-0002-4038-1536
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
A5064307721
Research Areas
  • ATP Synthase and ATPases Research
  • Acute Kidney Injury Research
  • Metabolomics and Mass Spectrometry Studies
  • Liver Disease and Transplantation
  • Cancer, Hypoxia, and Metabolism
  • Chronic Kidney Disease and Diabetes

Friedrich-Alexander-Universität Erlangen-Nürnberg
 2018-2019

 Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis
OPENALEX - Publications 
Gunnar Schley Bernd Klanke Joanna Kalucka Valentin Schatz Christoph Daniel and 12 more Marleen Mayer Margarete Goppelt‐Struebe Martin Herrmann Margrét Þorsteinsdóttir Runólfur Pálsson Angelika Beneke Dörthe M. Katschinski Nicolai Burzlaff Kai‐Uwe Eckardt Alexander Weidemann Jonathan Jantsch Carsten Willam

10.1016/j.kint.2019.02.016 article EN publisher-specific-oa Kidney International 2019-03-05
 A Fluorescent Benzo[g]isoquinoline‐Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging
OPENALEX - Publications 
Marleen Mayer Kerstin Fey Eva Heinze Christian R. Wick Martine I. Abboud and 9 more Tzu‐Lan Yeh Anthony Tumber Nicole Orth Gunnar Schley Bjoern Buchholz Timothy Clark Christopher J. Schofield Carsten Willam Nicolai Burzlaff

Prolyl hydroxylation domain (PHD) enzymes catalyze the of transcription factor hypoxia-inducible (HIF) and serve as cellular oxygen sensors. HIF PHD regulate numerous potentially tissue-protective target genes which can adapt cells to metabolic ischemic stress. We describe a fluorescent inhibitor (1-chloro-4-hydroxybenzo[g]isoquinoline-3-carbonyl)glycine is suited fluorescence-based detection assays for monitoring inhibitors in biological systems. In cell-based assays, application allowed...

10.1002/cmdc.201800483 article EN ChemMedChem 2018-10-31
Coming Soon ...