A5039142882- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Liver Disease Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Metabolism and Genetic Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Synthesis and Reactions of Organic Compounds
- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Body Composition Measurement Techniques
- Biochemical effects in animals
- Exercise and Physiological Responses
- Environmental Toxicology and Ecotoxicology
- Effects and risks of endocrine disrupting chemicals
- Endoplasmic Reticulum Stress and Disease
- Carcinogens and Genotoxicity Assessment
- Lipid metabolism and biosynthesis
- Cardiovascular Disease and Adiposity
- Genetics, Aging, and Longevity in Model Organisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Structural and Chemical Analysis of Organic and Inorganic Compounds
University of Salerno
2017-2024
University of Naples Federico II
2009-2023
Parthenope University of Naples
2019
University of Pavia
1959
Background Mitochondria are dynamic organelles that frequently undergo fission and fusion processes, imbalances in these processes may be involved obesity insulin resistance. Aims The present work had the following aims: (a) to evaluate whether mitochondrial dysfunction hepatic steatosis induced by a high-fat diet is associated with changes dynamics morphology; (b) effects on above parameters differ between high-lard high-fish-oil diets, as it has been suggested fish oil have anti-obesity...
OBJECTIVE High-fat diets (HFDs) are known to induce insulin resistance. Previously, we showed that 3,5-diiodothyronine (T2), concomitantly administered rats on a 4-week HFD, prevented gain in body weight and adipose mass. Here investigated whether how T2 HFD-induced RESEARCH DESIGN AND METHODS We the biochemical targets of related lipid glucose homeostasis over time using various techniques, including genomic proteomic profiling, immunoblotting, transient transfection, enzyme activity...
The changes in metabolic efficiency, body composition, and nutrient partitioning induced by high-fat feeding were evaluated adult rats (90d of age). alterations serum free triiodothyronine, insulin, leptin levels, as well hepatic skeletal muscle metabolism, also assessed. Rats fed either a low- or diet for 2 weeks. Relative to the low-fat feeding, energy intake expenditure, body-energy gain, lipid energetic increased feeding. Increased levels accompanied these variations. A positive...
Various studies have shown that eicosapentaenoic acid (EPA) has beneficial effects on obesity and associated disorders. Apelin, the ligand of APJ receptor also exerts insulin-sensitizing especially by improving muscle metabolism. EPA been to increase apelin production in adipose tissue but its not addressed. Thus, supplementation (36 g/kg EPA) high-fat diet (HFD) (45% fat, 20% protein, 35% carbohydrate) were studied mice with focus lipid metabolism apelin/APJ expression. Compared HFD mice,...
Excess sodium intake is a recognised causal factor of hypertension and its cardiovascular complications; there however lack practical instruments to assess monitor the level knowledge behaviour about dietary salt relate these factors population general habits.
The catalytic and antioxidant properties of platinum nanoparticles (PtNPs) make them promising candidates for several applications in nanomedicine. However, an open issue, still shared among most nanomaterials, is the understanding on how internalized PtNPs, which are confined within endo-lysosomal compartments, can exert their activities. To address this problem, here we study protective effect 5 nm PtNPs a human hepatic (HepG2) cell line exposed to dichlorodiphenylethylene (DDE) as model...
An accelerated rate of fat recovery (catch-up fat) and insulin resistance are characteristic features weight after caloric restriction, with implications for the pathophysiology catch-up growth fluctuations. Using a previously described rat model in which skeletal muscle have been linked to suppressed thermogenesis per se, we investigated alterations mitochondrial energetics oxidative stress subsarcolemmal (SS) intermyofibrillar (IMF) mitochondria. After 2 weeks semistarvation followed by 1...
Dietary PUFA , mainly those of the n ‐3 family, are known to play essential roles in maintenance energy balance and reduction body fat deposition through upregulation mitochondrial uncoupling that is main source reactive oxygen species. We hypothesized rat supplementation with raw donkey's milk ( DM ), characterized by low‐fat content higher 3: 6 ratio, may affect balance, lipid metabolism, prooxidant status as compared animals treated cow's milk. In present study, effects drinking (for 4...
Dietary fat sources may differentially affect the development of inflammation in insulin-sensitive tissues during chronic overfeeding. Considering anti-inflammatory properties ω-3 fatty acids, this study aimed to compare effects high-fish oil and high-lard diets on obesity-related by evaluating serum tissue adipokine levels histological features (white adipose tissue, skeletal muscle liver). As expected, a diet induced systemic peripheral insulin resistance. Conversely, compared with diet,...
The high fat diet (HFD) rich in lard induces obesity, inflammation and oxidative stress, the deregulation of hypothalamic nuclei plays an important role this mechanism. One factor involved food intake is adenosine monophosphate-dependent kinase (AMPK), a serine/threonine activated by phosphorylation. Omega (ω)3-polyunsaturated fatty acids (PUFA) are dietary compounds known to attenuate obesity-related diseases, although molecular mechanisms underlying their actions hypothalamus not...