A5017020259- Wood and Agarwood Research
- Microbial Metabolism and Applications
- Cultural Heritage Materials Analysis
- Identification and Quantification in Food
- Phytochemical Studies and Bioactivities
- Microbial Natural Products and Biosynthesis
- Biological Stains and Phytochemicals
- Phytochemical compounds biological activities
- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Plant Gene Expression Analysis
- Phytochemistry and Bioactive Compounds
- Tea Polyphenols and Effects
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- Marine Sponges and Natural Products
- Polysaccharides and Plant Cell Walls
- Phytochemistry and Biological Activities
- Medicinal Plants and Neuroprotection
- Alkaloids: synthesis and pharmacology
- Bioactive natural compounds
- Chemical synthesis and alkaloids
- Biological and pharmacological studies of plants
- Advanced Synthetic Organic Chemistry
- Bioactive Natural Diterpenoids Research
Chinese Academy of Tropical Agricultural Sciences
2016-2025
Tropical Crops Genetic Resources Institute
2020-2024
Shanghai University
2023-2024
Chinese Academy of Agricultural Sciences
2021
Ministry of Agriculture and Rural Affairs
2018-2020
Hainan Agricultural School
2016-2020
Haikou City People's Hospital
2017-2019
Tropical Bioscience and Biotechnology Research Institute
2017
Hainan Medical University
2017
Hainan University
2009-2014
Covering: Up to the end of 2019.Agarwood is a resinous portion Aquilaria trees, which formed in response environmental stress factors such as physical injury or microbial attack. It very sought-after among natural incenses, well for its medicinal properties traditional Chinese and Ayurvedic medicine. Interestingly, chemical constituents agarwood healthy trees are quite different. Sesquiterpenes 2-(2-phenethyl)chromones with diverse scaffolds commonly accumulate agarwood. Similar structures...
The antioxidant activities of the ethanol, petroleum ether, ethyl acetate, n-butanol and water extract fractions from seeds papaya were evaluated in this study. acetate fraction showed strongest DPPH hydroxyl free radical-scavenging activities, its stronger than those ascorbic acid sodium benzoate, respectively. demonstrated greatest ABTS⁺ radicals scavenging activity. not only higher ether fraction, ethanol but also superoxide anion hydrogen peroxide other fractions. high amount total...
Six unprecedented bisindole alkaloids, trigolutesins A and B (1–2) with a unique polycyclic skeleton trigolutes A–D (3–6) another skeleton, were isolated from the twigs of Trigonostemon lutescens. Their structures relative configurations elucidated by spectroscopic data single-crystal X-ray diffraction crystallography. Trigolutesin (1) showed weak AChE inhibitory activity.
Rationale: Cardenolides have potential as anticancer drugs. 3'-epi-12β-hydroxyfroside (HyFS) is a new cardenolide structure isolated by our research group, but its molecular mechanisms remain poorly understood. This study investigates the relationship between antitumor activities and autophagy in lung cancer cells. Methods: Cell growth proliferation were detected MTT, lactate dehydrogenase (LDH) release, 5-ethynyl-20-deoxyuridine (EDU) colony formation assays. apoptosis was flow cytometry....
Abstract Backgroud Aquilaria sinensis (Lour.) Spreng is one of the important plant resources involved in production agarwood China. The resin collected from wounded trees has been used Asia for aromatic or medicinal purposes ancient times, although mechanism underlying formation still remains poorly understood owing to a lack accurate and high-quality genetic information. Findings We report genomic architecture A. by using an integrated strategy combining Nanopore, Illumina, Hi-C sequencing....
Agarwood is the fragrant resinous heartwood obtained from certain trees in genus Aquilaria belonging to family Thymelaeaceae. 2-(2-Phenylethyl)chromones and characteristic sesquiterpenes are main classes of aromatic compounds isolated agarwood. Although there many sesquiterpenes, relatively few 2-(2-phenylethyl)chromones have been determined agarwood by GC-MS. After analysis MS spectra eighteen 2-(2-phenylethyl)chromone derivatives identified NMR spectroscopy, together with reported data...
The ethyl ether extract of agarwood from an Aquilaria plant afforded six new sesquiterpenoids, Agarozizanol A - F (1-6), together with four known sesquiterpenoids and 2-(2-phenylethyl)chromones. Their structures were elucidated via detailed spectroscopic analysis, X-ray diffraction, comparisons the published data. All isolates evaluated for α-glucosidase tyrosinase inhibitory activities in vitro. Compounds 5, 7, 8, 10 showed significant inhibition IC50 values ranging between 112.3 ± 4.5...
Agarwood is highly valued for its uses as incense, perfume, and medicine. However, systematic analyses of dynamic changes secondary metabolites during the process agarwood formation have not yet been reported. In this study, was produced by transfusing inducer into trunk Aquilaria sinensis, changing patterns chemical constituents, especially 2-(2-phenylethyl)chromones (PECs), in wood samples collected from 1st to 12th month, were analyzed GC-EI-MS UPLC-ESI-MS/MS methods. Aromatic compounds,...
Dragon’s blood is a traditional medicine in which flavonoids are the main bioactive compounds; however, underlying formation mechanism of dragon’s remains largely poorly understood. Chalcone isomerase (CHI) key enzyme flavonoid biosynthesis pathway. However, CHI family genes not well understood Dracaena cambodiana Pierre ex Gagnep, an important source plant blood. In this study, 11 were identified from D. , and they classified into three types. Evolutionary transcriptional profiling analysis...
Background:Dendrobium nobile (D. nobile), a traditional Chinese medicine, has received attention as an anti-tumor drug, but its mechanism is still unclear. In this study, we applied network pharmacology, bioinformatics, and in vitro experiments to explore the effect of Dendrobin A, active ingredient D. nobile, against pancreatic ductal adenocarcinoma (PDAC). Methods: The databases SwissTargetPrediction PharmMapper were used obtain potential targets differentially expressed genes (DEGs)...
Phytochemical analysis of the high quality Chinese agarwood 'Qi-Nan' originating from Aquilaria sinensis (Lour.) Glig led to isolation a new 2-(2-phenylethyl)chromone derivative, qinanones G (1), and four known 2-(2-phenylethyl)chromones (2–5). Their structures were elucidated by spectroscopic techniques (UV, IR, 1D 2D NMR) MS analyses. The NMR data chromones 1–3 first reported, 2 3 showed weak inhibitory activity against acetylcholinesterase.
Two new sesquiterpenoids, 3-oxo-7-hydroxylholosericin A (1) and 1,5;8,12-diepoxy-guaia-12-one (2), together with seven known sesquiterpenoids 3–9, were isolated from Chinese agarwood induced by artificial holing originating Aquilaria sinensis (Lour.) Gilg. Their structures identified spectroscopic techniques (UV, IR, 1D 2D NMR) MS analyses. The absolute configuration of compound 1 was determined comparison its measured CD curve that calculated data for ent-1. NMR 3 reported in this study the...
Two new 2-(2-phenylethyl)chromones, (5S *,6R *,7S *)-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl)-5,6,7,8-tetrahydro-4H-chromen-4-one (1) and *,7R (2), were isolated from the Chinese eaglewood of Aquilaria sinensis (Lour.) Gilg. Their structures established by detailed MS NMR spectroscopic analysis, as well comparison with literature data.