A5078603496- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- Advanced Biosensing Techniques and Applications
- Glycosylation and Glycoproteins Research
- Protein purification and stability
- Nanoparticle-Based Drug Delivery
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Bacterial Infections and Vaccines
- Antimicrobial Peptides and Activities
- Genetics, Bioinformatics, and Biomedical Research
- SARS-CoV-2 and COVID-19 Research
- Peptidase Inhibition and Analysis
- CRISPR and Genetic Engineering
- Biosensors and Analytical Detection
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 Clinical Research Studies
- Animal Genetics and Reproduction
- Ethics in Clinical Research
- Microfluidic and Bio-sensing Technologies
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
Universidad Yachay Tech
2015-2023
City of Knowledge
2022
Central Luzon State University
2020
Universidad Católica de Oriente
2019
University of KwaZulu-Natal
2019
Université de Montréal
2019
University of Concepción
2019
Universidad San Francisco de Quito
2019
Secretaría de Educación Superior, Ciencia, Tecnología e Innovación
2015
Centro de Ingeniería Genética y Biotecnología
2001-2012
Spain has consistently demonstrated global leadership in organ transplantation, culminating record achievements 2024. With 6,464 transplants performed, including significant advancements kidney, liver, and lung procedures, reached a donation rate 52.6 per million population, surpassing international benchmarks. The success of the Spanish model is rooted its progressive legislation, clinical leadership, public awareness campaigns, fostering trust solidarity. Technological innovations, such as...
Abstract Protein Kinase (casein kinase 2, CK2) is a serine-threonine that frequently dysregulated in many human tumors. Therefore we hypothesized peptides capable of binding to the CK2 acidic domain may exhibit potential anticancer properties. By screening random cyclic peptide phage display library, have identified novel peptide, P15, abrogated phosphorylation by blocking substrate vitro. To verify its antineoplastic effect, P15 was fused cell-penetrating derived from HIV-Tat protein....
In this work we introduce a novel microfluidic enzyme linked immunoassays (ELISA) microplate as the next generation assay platform for unparalleled performances. A combination of technology with standard SBS-configured 96-well architecture, in form technology, allows improvement ELISA workflows, conservation samples and reagents, improved reaction kinetics, ability to improve sensitivity by multiple analyte loading. This paper presents design characterization microplate, its application ELISA.
Hydrogels are promising candidates for wound healing bandages because they can mimic the native skin microenvironment. Additionally, there is increasing growth in use of naturally derived materials and plant-based biomaterials to produce healthcare products with purposes their biocompatibility biodegradation properties. In this study, cellulose extracted from biodiverse sources Ecuador was used as raw material fabrication hydrogels enhanced antifouling Fourier-transform infrared (FTIR)...
This research reported a hydrogel loaded with the ethanolic and methanolic extracts of Eupatorium glutinosum Lam. The E. were characterized by phytochemical screening, Fourier-transform infrared spectroscopy (FTIR), thin-layer chromatography (TLC), UV/Vis profile identification. also evaluated pharmacological activity using antimicrobial, antioxidant, anti-inflammatory assays prior to polymeric encapsulation. Results indicate that inhibit Escherichia colii DH5-α (Gram negative) growth;...
Suture biomaterials are critical in wound repair by providing support to the healing of different tissues including vascular surgery, hemostasis, and plastic surgery. Important properties a suture material include physical properties, handling characteristics, biological response for successful performance. However, bacteria can bind sutures become source infection. For this reason, there is need new with antifouling properties. Here we report two types cellulose fibers from coconut (Cocos...
The development of hydrogels has a significant impact in fields such as tissue engineering and biomedical devices. present study tests different cellulose particles extracted from plants to produce identify if these have antimicrobial properties. Nine Ecuadoran biodiversity were obtained using an established chemical extraction protocol, characterized known techniques, evaluated for bacterial growth in-vitro . In addition, two nine selected perform rates adhesion assays. with F1 F53 similar...
Covalent cyclic peptides represent a transformative approach for targeting challenging protein-protein interactions (PPIs) characterized by flat, extensive binding surfaces. Recent advances in electrophilic phage display now enable the evolution of these through integrating sulfur(VI) fluoride exchange (SuFEx) chemistry with functional selection strategies. This innovative platform combines genetic encoding site-specific cyclization and warhead incorporation to generate high-affinity,...
Peptides are promising drug development frameworks thanks to their high target selectivity, tolerability and relatively low production cost. However, despite the fact that several thousand potentially therapeutic peptides reported, only sixty have arrived at market. This concerning proportion is partially explained by undesired properties such as peptide-induced hemolytic activity. Hence, we aim get a better insight into chemical space of using novel approach based on network science...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel Tyrosine Markers in Raman Spectra of Wild-Type and Mutant (Y21M Y24M) Ff Virions Indicate Unusual Environments for Coat Protein PhenoxylsStacy A. Overman, Kelly L. Aubrey, Nelson S. Vispo, Gianni Cesareni, George J. Thomas, Jr.Cite this: Biochemistry 1994, 33, 5, 1037–1042Publication Date (Print):February 8, 1994Publication History Published online1 May 2002Published inissue 8 February...
This paper presents a technique for microscopic classification of Aspergillus fungi species. In another study, the authors described process identification using macroscopic images. However, some images look similar even if it belongs to different The in this study includes and 9-type A machine learning model is trained validated 4545 CNN v1 achieved 87.50% accuracy training, 95.65% validation. re-calibrated improve training performance. v1.1 used softmax instead sigmoid activation, dropout...
Therapies aimed at enhancing cardiomyocyte survival following myocardial injury are urgently required. As GHRP6 [GH (growth hormone)-releasing peptide 6] has been shown to stimulate GH secretion and beneficial cardiovascular effects, the aim of present study was determine whether administration reduces infarct size acute coronary occlusion in vivo. Female Cuban Creole pigs were anaesthetized, monitored instrumented ensure a complete sudden left circumflex artery for 1 h, followed by 72 h...
We report the expression in E. coli of a proinsulin fusion protein carrying modified interleukin-2 N-terminal peptide linked to N-terminus by lysine residue. The key aspects investigated were: (a) fused IL2-PI gene, (b) folding efficiency insulin precursor when still N-fused and (c) selectivity enzymatic cleavage reaction with trypsin order remove simultaneously C-peptide extension. It was found that this construction expresses chimeric at high level (20%) as inclusion bodies; refolded...
This paper presents a technique for macroscopic classification of Aspergillus fungi species. The genus have several species that can be used in agricultural and medical applications. An automated process identification such is described here. scope the study includes 9-type learning mechanism simple convolutional neural network. Using total 4545 images, model achieved 90.06% accuracy training, 96.43% validation.