A5050235825- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Galectins and Cancer Biology
- Ion channel regulation and function
- Graphene and Nanomaterials Applications
- Glutathione Transferases and Polymorphisms
- Metal complexes synthesis and properties
- Ferroptosis and cancer prognosis
- Cytomegalovirus and herpesvirus research
- Genomics and Phylogenetic Studies
- Bladder and Urothelial Cancer Treatments
- Neuroscience and Neuropharmacology Research
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Drug Delivery Systems
- HIV Research and Treatment
- Advanced Nanomaterials in Catalysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Telomeres, Telomerase, and Senescence
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
University of California, Berkeley
2016-2018
Howard Hughes Medical Institute
2018
Sri Shankara Cancer Hospital and Research Center
2014
Kidwai Memorial Institute of Oncology
2007-2014
New York University
2009-2010
The University of Texas at Austin
2009
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTExosomal NADPH Oxidase: Delivering Redox Signaling for HealingLakshmi KrishnamoorthyLakshmi KrishnamoorthyDepartment of Chemistry, University California, Berkeley, California 94720, United StatesHoward Hughes Medical Institute, StatesMore by Lakshmi Krishnamoorthy and Christopher J. Chang*Christopher ChangDepartment StatesDepartment Molecular Cell Biology, StatesHelen Wills Neuroscience States*E-mail: [email protected]More...
Transition metals are essential, but deregulation of their metabolism causes toxicity. Here, we report that the compound NSC319726 binds copper to induce oxidative stress and arrest glioblastoma-patient-derived cells at picomolar concentrations. Pharmacogenomic analysis suggested 65 other structural analogs exhibit lethality through metal binding. Although has been reported function as a zinc ionophore, here this cell growth. We generated validated pharmacogenomic predictions: toxicity was...
Context: GSTP1 is a subgroup of glutathione-S-transferase family, which provides cellular protection against free radical and carcinogenic compounds due to its detoxifying function. Altered activity down regulation enzyme DNA methylation has been reported in many tumors, although data for ovarian cancer are few. In this study, we aimed at determining the expression relation promoter epithelial (EOC). Materials Methods: mRNA concentration were assessed by quantitative reverse transcriptase...