A5028688417- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- RNA Interference and Gene Delivery
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Reactions of Organic Compounds
- Graphene and Nanomaterials Applications
- Transgenic Plants and Applications
- Synthesis of Organic Compounds
- Quinazolinone synthesis and applications
- Bioactive Compounds and Antitumor Agents
- Advanced Polymer Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- Synthesis of Tetrazole Derivatives
- Cytokine Signaling Pathways and Interactions
- Plant tissue culture and regeneration
- Plant Genetic and Mutation Studies
- Natural product bioactivities and synthesis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Synthesis and Analysis
- Fungal and yeast genetics research
National Academy of Sciences of Ukraine
2014-2025
Institute of Cell Biology
2016-2025
Lviv University
2013-2024
Faculty (United Kingdom)
2018
A series of 11-substituted 9-hydroxy-3,5,10,11-tetrahydro-2H-benzo[6,7]thiochromeno[2,3-d][1,3]thiazole-2,5,10-triones 3.1-3.13 were synthesized via hetero-Diels-Alder reaction 5-ene-4-thioxo-2-thiazolidinones and 5-hydroxy-1,4-naphthoquinone (juglone). The structure newly compounds was established by means spectral data a single-crystal X-ray diffraction analysis. tested on panel cell lines representing different types cancer as well normal pseudonormal cells peripheral human blood...
A series of novel pyrrolidinedione-thiazolidinones was synthesized and subjected to physico-chemical characteristics. They were screened on a panel cell lines representing different types cancer, as well normal human keratynocytes lymphocytes peripheral blood. High antiproliferative activity 1-(4-chlorophenyl)- 1-(4-hydroxyphenyl)-3-{5-[(Z,2Z)-2-chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-1-(4-hydroxyphenyl)-pyrrolidine-2,5-diones 2a 2b revealed along with...
Particles with a porous structure can lead to quick hemostasis and provide good matrix for cell proliferation during wound healing.
Novel pyridine-thiazole hybrid molecules were synthesized and subjected to physico-chemical characterization screening of their cytotoxic action towards a panel cell lines derived from different types tumors (carcinomas colon, breast, lung, glioblastoma leukemia), normal human keratinocytes, for comparison. High antiproliferative activity the 3-(2-fluorophenyl)-1-[4-methyl-2-(pyridin-2-ylamino)-thiazol-5-yl]-propenone 3...
Keywords: thiazole derivatives, 2-amino-5-benzyl-1,3-thiazoles, anticancer activity, leukemia, glioblastoma, melanoma
Anticancer screening of several novel thienopyrimidines has been performed. The thienopyrimidine derivatives were synthesized from available starting materials according to the convenient synthetic procedures using a one-pot solvent-free reaction which gave wide access thienopyrimidine-derivative production. compounds preselected via molecular docking be tested for their anticancer activity in NCI 60 cell lines. It was observed that some showed remarkable activity. found most active compound...
The aim of the present study was to investigate antiproliferative and proapoptotic actions N-(5-benzyl-1,3-thiazol-2-yl)-3,5-dimethyl-1-benzofuran-2-carboxamide derivative (compound 5) in glioma cells comparison with temozolomide (TMZ) doxorubicin (Dox), used as positive controls. activity compound 5, TMZ, Dox on human glioblastoma U251 multiform T98G measured using MTT test. Western blot analysis, fluorescent microscopy, agarose gel retardation assay, flow cytometric DNA comet assay under...
Development of biocompatible multifunctional polymeric drug carriers is crucial in modern pharmaceutics aimed to create "smart" drugs. The high potential the PEGylated comb-like nanocarrier (PNC) delivering both traditional and experimental drugs tumor cells vitro vivo has been demonstrated previously. In present study, we investigated general toxicity polyethylene glycol (PEG) processed with covalent non-covalent attachments PEG compose a polymer that behaves like simple chain n monomers...
The aim. study aimed to synthesize and evaluate the anticancer activity of a series 2-chloro- 2,2-dichloroacetamides bearing thiazole scaffolds. Particular attention was paid their cytotoxic effects, chemical properties, action mechanisms, with focus on glutathione S-transferase (GST) inhibition as potential pathway for activity. Materials methods. compounds were synthesized using acylation reactions characterized via 1H 13C NMR spectroscopy well LC-MS. Their cytotoxicity assessed MTT assay...
Colorectal cancer is a major global health challenge, with current treatments limited by toxicity and resistance. Thiazole derivatives, known for their bioactivity, are emerging as promising alternatives. Juglone (5-hydroxy-1,4-naphthoquinone) naturally occurring compound anticancer properties, its incorporation into thiopyrano[2,3-d]thiazole scaffolds may enhance therapeutic potential. This study examined the cytotoxicity of thiopyrano[2,3-d]thiazoles effects on apoptosis in colorectal...
Keywords: thieno[3,2-e][1,2,3]triazolo[1,5-a]pyrimidines, thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines, thienotriazolopyrimidines, anticancer activity, fused pyrimidines
AimTo compare various pro-apoptotic effects of synthetic 4-thiazolidinone derivative (Les-3288), doxorubicin (Dox) and temozolomide (TMZ) in the treatment human glioma U251 cells to improve outcomes glioblastoma avoid anticancer drug resistance.MethodsThe cytotoxic drugs used were measured by cell viability proliferation assay (MTT), Trypan blue exclusion test, Western-blot analysis apoptosis-related proteins. In addition, flow cytometry study reactive oxygen species (ROS) level was carried...
Magnetic and temperature-sensitive solid lipid particles (mag.SLPs) were prepared in presence of oleic acid-coated iron oxide (IO-OA) nanoparticles with 1-tetradecanol poly(ethylene oxide)-block-poly(ε-caprolactone) as stabilizing surfactant-like agents, respectively. The particles, typically 850 nm hydrodynamic size, showed heat dissipation under applied alternating magnetic field. Cytotoxic activity mag.SLPs, nonmagnetic SLPs, was compared concerning mammalian cancer cell lines their...
Previously, we discovered that N-(5-benzyl-1,3-thiazol-2-yl)-4-(5-methyl-1H-1,2,3-triazol-1-yl)benzamide possessed a remarkable cytotoxic effect on 28 cancer cell lines with IC50 < 50 μM, including 9 lines, where was in the range of 2.02-4.70 μM. In present study, designed novel N-(5-benzylthiazol-2-yl)amide compound 3d synthesized using original bioisosteric replacement 1H-1,2,3-triazole ring by 1H-tetrazole ring. A significantly enhanced anticancer activity vitro an excellent anti-leukemic...
The genetic transformation of target cells is a key tool in modern biological research, as well many gene therapy and biotechnology applications. Here we describe new method for delivery DNA into several industrially important species yeast, including Saccharomyces cerevisiae. Our based on the use novel nanoscale oligoelectrolyte polymer possessing comb-like structure carrier molecule. Direct comparisons to standard methods clearly show that our approach: (i) yields two times more...