A5064335291- Cell Adhesion Molecules Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pharmacogenetics and Drug Metabolism
- Cellular Mechanics and Interactions
- RNA and protein synthesis mechanisms
- Force Microscopy Techniques and Applications
- Clostridium difficile and Clostridium perfringens research
- Computational Drug Discovery Methods
- Skin and Cellular Biology Research
- Cardiomyopathy and Myosin Studies
- Microbial Metabolic Engineering and Bioproduction
- Glycosylation and Glycoproteins Research
- Infection Control and Ventilation
- Infection Control in Healthcare
- Phagocytosis and Immune Regulation
- Drug-Induced Hepatotoxicity and Protection
- Listeria monocytogenes in Food Safety
- Cell death mechanisms and regulation
- RNA Research and Splicing
- Behavioral Health and Interventions
- Endoplasmic Reticulum Stress and Disease
- Cephalopods and Marine Biology
- Biosimilars and Bioanalytical Methods
- Gambling Behavior and Treatments
- Microtubule and mitosis dynamics
Max Planck Institute of Biochemistry
2019-2021
German Cancer Research Center
2015
Heidelberg University
2015
Cancer Research UK Scotland Institute
2013
Heinrich Heine University Düsseldorf
2010-2012
Philipps University of Marburg
2008
Williams College
1983
Roger Williams University
1983
Apoptosis is a fundamental homeostatic mechanism essential for the normal growth, development and maintenance of every tissue organ. Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, body formation intact cellular membranes to prevent massive protein release consequent inflammation. We now show that during early apoptosis limited membrane permeabilization occurs in blebs bodies, which allows proteins may affect...
Focal adhesions (FAs) are protein machineries essential for cell adhesion, migration, and differentiation. Talin is an integrin-activating tension-sensing FA component directly connecting integrins in the plasma membrane with actomyosin cytoskeleton. To understand how talin function regulated, we determined a cryoelectron microscopy (cryo-EM) structure of full-length talin1 revealing two-way mode autoinhibition. The actin-binding rod domains fold into 15-nm globular arrangement that...
Integrin α 5 β 1 structures in resting and active states with ligand fibronectin reveal key interactions for integrin opening.
Upon severe DNA damage a cellular signalling network initiates cell death response through activating tumour suppressor p53 in association with promyelocytic leukaemia (PML) nuclear bodies. The deacetylase Sirtuin 1 (SIRT1) suppresses after by antagonizing acetylation. To facilitate efficient acetylation, SIRT1 function needs to be restricted. How activity is regulated under these conditions remains largely unclear. Here we provide evidence that limited upon phosphorylation the...
Focal adhesions (FA) are large macromolecular assemblies which help transmit mechanical forces and regulatory signals between the extracellular matrix an interacting cell. Two key proteins talin vinculin connecting integrin to actomyosin networks in Both bind F-actin each other, providing a foundation for network formation within FAs. However, underlying mechanisms regulating their engagement remain unclear. Here, we report on results of vitro reconstitution talin-vinculin-actin using...
Inverse acinar regulation of Mrp2 and 3 represents an adaptive response to hepatocellular cholestatic injury. We studied whether obstructive cholestasis (bile duct ligation) LPS treatment affect the zonal expression Bsep (Abcb11), Mrp4 (Abcc4), Ntcp (Slc10a1), Oatp isoforms (Slco1a1, Slco1a4, slco1b2) in rat liver, as analyzed by semiquantitative immunofluorescence. Contribution TNF-α IL-1β transporter zonation was cytokine inactivation. In normal liver Bsep, Mrp4, Ntcp, Oatp1a1 were...
To test the hypothesis that drinking alcohol increases involvement in a structured social situation, 96 volunteer college students were assigned to either an or non-alcohol condition. Subjects played standard Monopoly game for maximum of 3 hr. A checklist was used record observations their behavior. Analysis indicates subjects alcohol-drinking groups had longer playing time, built more hotels, and consumed beverage than who These results interpreted as reflection increased situation game.