A5068226666- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Single-cell and spatial transcriptomics
- Neuroscience and Neural Engineering
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Gene Regulatory Network Analysis
- Receptor Mechanisms and Signaling
- stochastic dynamics and bifurcation
- Biochemical Analysis and Sensing Techniques
- Advanced Chemical Sensor Technologies
- CRISPR and Genetic Engineering
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Bioinformatics and Genomic Networks
- Bacterial Genetics and Biotechnology
- Molecular Communication and Nanonetworks
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
Chinese Academy of Sciences
2022-2025
Czech Academy of Sciences, Institute of Biophysics
2025
Institute of Biophysics
2022
Cold Spring Harbor Laboratory
2018-2022
Baylor College of Medicine
2012-2017
Texas Children's Hospital
2015-2017
Neurological Research Institute
2015-2017
Peking University
2010-2014
Design and synthesis of basic functional circuits are the fundamental tasks synthetic biologists. Before it is possible to engineer higher‐order genetic networks that can perform complex functions, a toolkit devices must be developed. Among those devices, sequential logic expected foundation information‐processing systems. In this study, we report design construction circuit in Escherichia coli . It generate different outputs response same input signal on basis its internal state, ‘memorize’...
Channelrhodopsin-2 (ChR2) has quickly gained popularity as a powerful tool for eliciting genetically targeted neuronal activation. However, little been reported on the response kinetics of optogenetic stimulation across different subtypes. With excess stimulation, neurons can be driven into depolarization block, state where they cease to fire action potentials. Herein, we demonstrate that light-induced block in expressing ChR2 poses experimental challenges stable activation specific cell...
Recent studies have found that those who suffer from posttraumatic stress disorder (PTSD) are more likely to experience dementia as they age, most often Alzheimer's disease (AD). These findings suggest the symptoms of PTSD might an exacerbating effect on AD progression. and also share common susceptibility factors such trauma-induced were already succumb with age. Here, we explored these two hypotheses using a mouse model in wild-type animals. We expression human familial mutations amyloid...
Proper brain function relies on exquisite balance between excitation and inhibition, where inhibitory circuits play fundamental roles toward sculpting principle neuron output information processing. In prominent models of olfactory bulb circuitry, inhibition mitral cells by local interneurons sharpens odor tuning provides contrast enhancement. Mitral cell occurs at both apical dendrites deep-layer dendrodendritic synapses granule cells, the most abundant population in bulb. However, it...
Elucidating patterns of functional synaptic connectivity and deciphering mechanisms how plasticity influences such is essential toward understanding brain function. In the mouse olfactory bulb (OB), principal neurons (mitral/tufted cells) make reciprocal connections with local inhibitory interneurons, including granule cells (GCs) external plexiform layer (EPL) interneurons. Our current between these cell types, as well their experience-dependent plasticity, remains incomplete. By combining...
Parental care is altruistic. In natural environments, parents are often faced with challenging environmental conditions, such as severe weather, complex terrain and predatory threats, therefore need to overcome the fear of adverse conditions protect raise offspring. Although a few studies have reported risk-taking maternal behaviors, it unknown how motivation threats represented integrated in neural circuits resolve conflict dynamically drive behaviors. Here we report novel behavior paradigm...
Transsynaptic circuit tracing using genetically modified rabies virus (RV) is an emerging technology for identifying synaptic connections between neurons. Complementing this methodology, it now possible to assay the basic molecular and cellular properties of neuronal lineages derived from embryonic stem cells (ESCs) in vitro, these are under intense investigation toward devising cell replacement therapies. Here, we report generation a novel mouse ESC (mESC) line that harbors genetic elements...
Abstract The neural substrates for processing classical rewards such as food or drugs of abuse are well-understood. In contrast, the mechanisms by which organisms perceive social contact rewarding and subsequently modify their interactions unclear. Here we tracked gradual emergence a repetitive highly-stereotyped parental behavior show that trial-by-trial performance correlates with history midbrain dopamine (DA) neuron activity. We used novel paradigm to manipulate subject’s expectation...
Summary Comprehensive analysis of neuronal networks requires brain-wide measurement connectivity, activity, and gene expression. Although high-throughput methods are available for mapping activity transcriptomes, comparable region-to-region connectivity remain slow expensive because they require averaging across hundreds brains. Here we describe BRICseq, which leverages DNA barcoding sequencing to map from single individuals in a few weeks at low cost. Applying BRICseq the mouse neocortex,...