A5039306067- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Congenital Anomalies and Fetal Surgery
- Head and Neck Cancer Studies
- Health Systems, Economic Evaluations, Quality of Life
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Ethics in Clinical Research
- Total Knee Arthroplasty Outcomes
- Lymphatic System and Diseases
- Diabetes Management and Research
- Autoimmune Bullous Skin Diseases
- Advanced Causal Inference Techniques
- Celiac Disease Research and Management
- Machine Learning in Healthcare
- Foot and Ankle Surgery
- Neurological and metabolic disorders
- Oral health in cancer treatment
- Explainable Artificial Intelligence (XAI)
- CAR-T cell therapy research
- Diabetes Treatment and Management
- Tendon Structure and Treatment
- Knee injuries and reconstruction techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Microscopic Colitis
University of Freiburg
2021-2025
University Medical Center Freiburg
2022
Johannes Wesling Klinikum Minden
2015
The University of Texas MD Anderson Cancer Center
2012
Abstract 5q-associated spinal muscular atrophy is a rare neuromuscular disorder with the leading symptom of proximal muscle weakness. Three different drugs have been approved by European Medicines Agency and Food Drug Administration for treatment patients, however, long-term experience still scarce. In contrast to clinical trial data restricted patient populations short observation periods, we report here real-world evidence on broad spectrum patients early-onset treated nusinersen focusing...
Abstract Background The development and approval of disease modifying treatments have dramatically changed progression in patients with spinal muscular atrophy (SMA). Nusinersen was approved Europe 2017 for the treatment SMA irrespective age severity. Most data on therapeutic efficacy are available infantile-onset SMA. For type 2 3, there is still a lack sufficient evidence long-term experience nusinersen treatment. Here, we report from SMArtCARE registry non-ambulant children typen 3 under...
Background and objectives: Disease progression in patients with spinal muscular atrophy (SMA) has changed dramatically within the past years due to approval of three different disease-modifying treatments. Nusinersen was first drug be approved for treatment SMA patients. Clinical trials provided data from infants type 1 children 2, but there is still insufficient evidence only scarcely reported long-term experience nusinersen ambulant Here, we report SMArtCARE registry under a follow-up...
Importance The number of older adults with head and neck squamous cell carcinoma (HNSCC) is increasing, these patients are underrepresented in clinical trials. It unclear whether the addition chemotherapy or cetuximab to radiotherapy associated improved survival HNSCC. Objective To examine definitive locoregionally advanced (LA) Design, Setting, Participants Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy (SENIOR) study an international, multicenter cohort including...
Abstract Background As part of the German Medical Informatics Initiative, MIRACUM project establishes data integration centers across ten university hospitals. The embedded Use Case “Alerting in Care - IT Support for Patient Recruitment”, aims to support recruitment into clinical trials by automatically querying repositories patients satisfying eligibility criteria and presenting them as screening candidates. objective this study is investigate whether developed tool has a positive effect on...
There has long been discussion regarding the impact of medial malleolar osteotomies (MMO) as an adjunctive treatment for osteochondral lesions talus (OCLT). MMO may improve visibility and accessibility talus, but they also pose a risk periprocedural morbidity. is lack research about prevalence consequences in surgical OCLT.
The number of older adults with head and neck squamous cell carcinoma (HNSCC) is increasing, treatment these patients challenging. Although cisplatin-based chemotherapy concomitantly radiation therapy considered the standard regimen for locoregionally advanced HNSCC, there substantial real-world heterogeneity regarding concomitant in HNSCC.
Der Patient mit Diabetes mellitus weist ein stark erhöhtes Risiko für kardiovaskuläre ischämische Ereignisse, schlafbezogene Atmungsstörungen (obstruktives Schlafapnoe-syndrom), Herzinsuffizienz, Vorhofflimmern und weiteren Herzrhythmusstörungen sowie plötzlichem Herztod auf.
A considerable amount of melanoma patients show primary resistance to PD-1 and CTLA-4 inhibitors. We have previously reported a beneficial role intralesional Interleukin-2 (IL-2) in 9 developing new locoregional metastases under immunotherapy. now expanded this retrospective cohort 27 patients. Patients were evaluated for their tumor characteristics, treatment response progression-free overall survival (PFS/OS). In 16 patients, biopsies before IL-2 immune markers. The median follow-up time...
(Abstracted from JAMA Pediatr 2024;178(6):540–547 Spinal muscular atrophy (SMA) is a genetic disorder characterized by progressive muscle weakness and atrophy, with the most severe cases leading to ventilator dependency or death within 2 years. Three new therapies have significantly improved outcomes, especially early treatment.
Cumulative cisplatin doses of ≥ 200 mg/m2 improve survival in adults with head-and-neck squamous cell carcinoma (HNSCC) undergoing chemoradiation, but many older HNSCC cannot receive this prognostically relevant dose due to toxicities. This study aims develop predictive models assess the likelihood receiving during chemoradiation. 366 patients from SENIOR database, an international cohort 65 years HNSCC, received definitive chemoradiation single-agent and were analyzed. A Generalized Linear...
The recovery of strength is a key element in successfully returning to sports after ACL reconstruction. type anaesthesia has been suspected an influential factor the post-operative muscle function.In this retrospective analysis, n = 442 consecutive patients undergoing primary isolated reconstruction using hamstring autograft were analysed by pre- and isokinetic tests single orthopaedic centre. These subdivided into four cohorts: (1) general (n 47), (2) with prolonged (48 h) on-demand femoral...
Introduction Dermatitis herpetiformis (DH) is a rare autoimmune, polymorphous blistering disorder, characterized by severe itch or burning sensation, which represents the cutaneous manifestation of celiac disease (CD). The current estimation DH versus CD around 1:8 and affected individuals have genetic predisposition. Pathogenetically, IgA autoantibodies against epidermal transglutaminase, an essential constituent epidermis, cause are reported to develop through cross-reaction with tissue...
In clinical settings, we often face the challenge of building prediction models based on small observational data sets. For example, such a set might be from medical center in multi-center study. Differences between centers large, thus requiring specific target center. Still, want to borrow information external centers, deal with sample sizes. There are approaches that either assign weights each or observation. To incorporate differences sets and observations, propose an approach combines...
: For patients with percutaneous coronary intervention (PCI) of an unprotected left main artery (uLMCA) stenosis, the optimal duration dual antiplatelet therapy (DAPT) remains a matter debate. The purpose this study was to compare clinical outcomes 6- versus 12-month DAPT in PCI uLMCA and stable angina.
Background: To provide more evidence in urolithiasis research, we have established the German Nationwide Register for RECurrent URolithiasis (RECUR) using local clinical data warehouses (CDWH). For RECUR and other registers relying on digitalized data, it is crucial to ensure data's reliability answering scientific questions. In this work, aim compare results of different CDWH-based queries cases next manual case extraction from primary source. Methods: Sources included Medical Center...
ABSTRACT In a longitudinal clinical registry, different measurement instruments might have been used for assessing individuals at time points. To combine them, we investigate deep learning techniques obtaining joint latent representation, to which the items of are mapped. This corresponds domain adaptation, an established concept in computer science image data. Using proposed approach as example, evaluate potential adaptation cohort setting with rather small number points, motivated by...
Abstract Currently, there are no good biomarkers to predict targeted therapy outcomes for patients whose cancers recur vs. those that do not. Technology limitations have prevented extensive qRT-PCR biomarker analysis on small tumor tissue samples obtained in our unique lung cancer MD Anderson BATTLE clinical trials. Clinical sample size inherent due the extremely core needle biopsies (CNB) and fine aspirates (FNA). Identifying technology can reliably analyze, a quantitative manner, molecular...
In a longitudinal clinical registry, different measurement instruments might have been used for assessing individuals at time points. To combine them, we investigate deep learning techniques obtaining joint latent representation, to which the items of are mapped. This corresponds domain adaptation, an established concept in computer science image data. Using proposed approach as example, evaluate potential adaptation cohort setting with rather small number points, motivated by application...