A5013788817- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Wastewater Treatment and Nitrogen Removal
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Geochemistry and Elemental Analysis
- Analytical Methods in Pharmaceuticals
- Constructed Wetlands for Wastewater Treatment
- Cancer Research and Treatments
- Acute Kidney Injury Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Fungal Infections and Studies
- Asthma and respiratory diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Vitamin K Research Studies
- Advancements in Transdermal Drug Delivery
- Influenza Virus Research Studies
- COVID-19 diagnosis using AI
- Microbial Community Ecology and Physiology
- Hepatitis B Virus Studies
Shanghai Jiao Tong University
2025
First Affiliated Hospital Zhejiang University
2018-2022
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2018-2022
Zhejiang University
2018-2022
Creative Commons
2022
Jilin University
2010
First Hospital of Jilin University
2010
Abstract Background Patients with hepatitis B‐related acute‐on‐chronic liver failure (HB‐ACLF) may have an increased circulating microbial burden. This study aimed to assess load and composition explore the association between microbiome both systemic inflammation (SI) clinical outcome in HB‐ACLF. Methods Plasma from 50 HB‐ACLF patients, 23 healthy controls 25 patients compensated cirrhosis (C‐LC) was analysed for chemokines/cytokines bacterial DNA further by 16S rDNApyrosequencing. Linear...
The aim of this study was to investigate the host factors patients with COVID-19 that were associated delayed viral RNA clearance in specimens obtained from upper respiratory tract.A median a 32-day period shedding observed, ranging 4 days 111 days. On multivariate analysis, elderly age independently prolonged (OR = 1.02, 95% CI: 1.01-1.04, P 0.003). An incremental increase duration observed increasing (P < 0.05). (quartile) 23 (22) (≤ 40 years), 30 (18) (41-50 33 (21) (51-60 34 (17) (61-70...
Acute-on-chronic liver failure (ACLF) is characterized by systemic inflammation accompanied defective anti-bacterial immunity. The role of neutrophils in immune derangement ACLF has not been fully elucidated. This study aimed to characterize the circulating HBV-related patients.Quantitative, phenotypic, transcriptomic, and functional alterations were compared non-ACLF subjects analyzed for associations with short-term outcomes. Interventional experiments performed test impact on ACLF-patient...
Background: The purpose of this study is to describe the epidemiological features bacterial infections caused by multidrug-resistant (MDR) bacteria in cirrhotic patients and their impact on mortality.Methods: A retrospective with culture-confirmed was performed between 2011 2017.Results: total 635 episodes 563 cirrhosis were included. Bacterial MDR isolates accounted for 44.1% (280/635) episodes, nearly half which hospital acquired (48.4%). most common isolation site respiratory tract...
Flare-ups of chronic hepatitis B can sometimes be severe and even progress to acute-on-chronic liver failure (ACLF), with high short-term mortality. A timely estimation the risk death should initiated early. The aim present study was determine whether novel biomarkers add prognostic information beyond current clinical scoring systems.Patients B-associated ACLF were prospectively enrolled from five hospitals in China between August 2017 March 2018. Their plasma screened for soluble CD163...
We aimed to analyze the level of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in neutrophils ischemic stroke (IS) patients at different stages, together with its roles neutrophils.Sixty-seven were classified into acute phase group (n = 19), subacute 28), and stable 20), 20 healthy individuals who had received physical examination same time period as control. then analyzed expression CEACAM1 viability positive negative by flow cytometry content plasma CEACAM1,...
Background: The aim of this study was to investigate the impact proton pump inhibitor (PPI) therapy on complications and prognosis in cirrhosis patients with without acute-on-chronic liver failure (ACLF). Materials Methods: Cirrhosis acute decompensation (AD) (n = 489) admitted our center were enrolled prospective observational cohort study. According treatment received, identified as users or nonusers PPI. Clinical laboratory data, during hospitalization, overall survival recorded all...
Abstract Background: The recent outbreak of SARS-CoV-2 infection results in a considerable morbidity and mortality, mainly China. study is to investigate the intrinstic features infected patients that associated with severe type this disease. Method: A total 487 laboratory-confirmed COVID-19 were included analysis. demographic epidemiological representing as mild at admission compared. step-wise multivariate logistic regression analysis performed identify significant risk factors . score...
It is critical but challenging to predict the prognosis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). This study systematically summarized and evaluated quality performance available clinical prediction models (CPMs).A keyword search articles on HBV-ACLF CPMs published in PubMed from January 1995 April 2020 was performed. Both were assessed.Fifty-two identified, which 31 specific. The modeling data mostly derived retrospective (83.87%) single-center (96.77%)...
Cryptococcal meningitis (CM) is a common opportunistic infection in HIV-negative patients, with mortality rates as high those the population. This requires accurate initial clinical decision-making, warranting development of prognostic score. Two groups patients were investigated separately to develop novel model (AAIT) for CM. A retrospective analysis 201 CM was conducted In addition, cohort (n = 21) recruited longitudinally verify new Meanwhile, association between score and 1-year...
Aims: Patients with hepatitis B-related acute-on-chronic liver failure (HB-ACLF) may have an increased circulating microbial burden. This study aimed to assess load and composition explore the association between microbiome both systemic inflammation clinical outcome in HB-ACLF. Methods: Plasma from 49 HB-ACLF patients, 15 healthy controls (HCs) 18 patients compensated cirrhosis (C-LC) was analyzed for chemokines/cytokines bacterial DNA further analysed by 16S rDNA pyrosequencing. Linear...
Abstract Background: Bacterial infections are common in patients with decompensated cirrhosis, largely owing to bacterial translocation and cirrhosis-associated immune dysfunction. This study aims determine the reliability for classifying cirrhosis based on Centers Disease Control Prevention (CDC) criteria. Methods: The suspicious infection a registered prospective cohort of from May 1, 2014 February 25, 2015 ward First Affiliated Hospital Zhejiang University were retrospectively identified....
We attempts to exam the clinical efficacy of fluid resuscitation combined with ulinastatin in treatment patients sepsis and analyze effects combination on acute physiology chronic health evaluation II score, sequential organ failure assessment oxygenation index inflammatory factors. chose 60 from July 2020 2021 intensive care unit ward our hospital as study cohort. Divided them into two groups, one is control group (n=30) other observation randomly. Patients were offered basic treatments...
Abstract Background Tissue damage, expecially blood-brain barrier (BBB) injury caused by inflammatory factor storm and stroke-associated infection (SAI) during cerebral stroke is an important affecting the prognosis of patients. We aim to analyze level carcinoembryonic antigen-related cell adhesion molecule 1 ( CEACAM1 ) together with multiple mediators at different stages ischemic (IS), as well investigate role potential underlying mechanism in IS meanwhile. Methods The frequency positive...