A5005437747- Phytoestrogen effects and research
- Ginseng Biological Effects and Applications
- Protein Hydrolysis and Bioactive Peptides
- Herbal Medicine Research Studies
- Pharmacological Effects of Natural Compounds
- Bone health and osteoporosis research
- Probiotics and Fermented Foods
- Andrographolide Research and Applications
- Cholinesterase and Neurodegenerative Diseases
- Gut microbiota and health
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Phytochemistry and Bioactivity Studies
- Transgenic Plants and Applications
- Insect Utilization and Effects
- Marine Sponges and Natural Products
- Medicinal Plants and Neuroprotection
- Bone Metabolism and Diseases
- Bee Products Chemical Analysis
- Pregnancy and Medication Impact
- Phytase and its Applications
- Microplastics and Plastic Pollution
- Natural product bioactivities and synthesis
- Chemokine receptors and signaling
- Child and Adolescent Health
Korea Institute of Toxicology
2022-2025
Kyungpook National University
2019-2022
Universiti Tunku Abdul Rahman
2013-2019
Universiti Putra Malaysia
2012
Atopic dermatitis (AD) is an allergic and chronic inflammatory skin disease. The present study investigates the anti-allergic, antioxidant, anti-inflammatory activities of ethanolic extract Cornus officinalis (COFE) for possible applications in treatment AD. COFE inhibits release β-hexosaminidase from RBL-2H3 cells sensitized with dinitrophenyl-immunoglobulin E (IgE-DNP) antibody after stimulation dinitrophenyl-human serum albumin (DNP-HSA) a concentration-dependent manner (IC50 = 0.178...
In the present study, we investigated potential immunomodulatory effects of heat-killed (hLR) and live Limosilactobacillus reuteri PSC102 (LR; formerly Lactobacillus PSC102) in RAW264.7 macrophage cells Sprague–Dawley rats. murine were stimulated with hLR LR for 24 h. Cyclophosphamide (CTX)-induced immunosuppressed rats orally administered three doses (L-Low, M-Medium, H-High) 3 weeks. The phagocytic capacity, production nitric oxide (NO), expression cytokines measured, different parameters...
Ferns contain natural products with potential therapeutic applications. Current knowledge of the pharmacological properties ferns, specifically those growing at high altitudes, is limited. This study aimed to evaluate phytochemical contents as well antibacterial, anti-glucosidase, and antioxidant activities four highland ferns in Malaysia.Aqueous extracts leaves rhizomes Cyathea latebrosa, Dicranopteris curranii, Gleichenia truncata, Phymatopteris triloba were analysed. P. leaf extract had...
Hematopoiesis is the production of blood cells from hematopoietic stem (HSCs) that reside in bone marrow. Cyclophosphamide (CTX) a chemotherapy drug suppresses immune system. Korean Red Ginseng (KRG) and Colla corii asini (CCA) have been traditionally used for boosting system.HSCs marrow, cell subtype splenocytes, PBMCs, thymocytes were investigated. Serum levels hematopoietic-related markers analyzed using ELISA. Protein expression spleen tissue was western blot analysis. Hematoxylin &...
Methotrexate (MTX) is a widely used chemotherapeutic and immunosuppressive agent. It frequently detected in the environment due to its low biodegradability toxic properties, which may pose risk humans via contaminated drinking water. MTX impacts brain development; however, underlying mechanisms remain poorly understood. In this study, we aimed investigate potential of cortical organoids (COs) exhibit developmental neurotoxicity upon exposure elucidated mechanisms. We showed that affected...
The leaves of Homalomena aromatica are traditionally used in Bangladesh for the treatment different chronic ailments. purpose this study was to explore vitro antioxidant, thrombolytic activities, and vivo neuropharmacological effects methanolic extract (MEHA) leaves. Antioxidant activity MEHA assessed by a DPPH free radical scavenging assay total phenolics content, flavonoids content were also measured. determined percentage clot lysis activities hole board, tail suspension, forced swimming...
The immune functions of heat-killed Limosilactobacillus reuteri PSC102 (hLR) were investigated in cyclophosphamide (CP)-treated immunosuppressed mice. BALB/c mice randomly divided into five groups: normal control group, CP treated with levamisole (positive group), and low- high-dose hLR. After receiving the samples for 21 days, sacrificed, different parameters, such as organ index, blood cells, splenocyte proliferation, lymphocyte subpopulations, cytokines, immunoglobulins, analyzed. Results...
Invasive infections due to foodborne pathogens, including Salmonella enterica serovar Typhimurium, are prevalent and life-threatening. This study aimed evaluate the effects of ginsenoside Rg3 (Rg3) on adhesion, invasion, intracellular survival S. Typhimurium.The impacts bacterial growth host cell viability were determined using time kill 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assays, respectively. Gentamicin assay confocal microscopic examination undertaken...
Trifolium pratense (red clover) ethanolic extract (TPEE) has been used as a popular over-the-counter remedy for the management of menopausal symptoms. Prolonged consumption herbal shown to regulate composition gut microbiota. This study was designed elucidate influence TPEE on microbiota in ovariectomized (OVX) rats.OVX rats were treated with at 125, 250, 500 mg/kg/day, or controls (pomegranate extract, mg/kg/day; estradiol, 25 μg/kg/day) 12 weeks. Gut analysis conducted by extracting...
Hypercoagulability is frequently observed in patients with severe coronavirus disease-2019 (COVID-19). Platelets are a favorable target for effectively treating hypercoagulability COVID-19 as platelet hyperactivity has also been observed. It difficult to develop treatment that will be effective against all variants and the use of antivirals may not fully activated platelets have detected COVID-19. Therefore, less side effects often turn toward natural remedies. Numerous phytochemicals being...
Purpose: To determine the phenolic constituents as well anti-proliferative, antioxidant and ironchelating activities of leaf rhizome extracts Phymatopteris triloba.Methods: Concentrations selected hydroxybenzoic acids, hydroxycinnamic acids flavonoids in aqueous were quantified using high performance liquid chromatography (HPLC). Antiproliferative activity was assessed on human cervix cancer cell line (HeLa) chronic myelogenous leukemia (K562). Superoxide nitric oxide scavenging...
Recent years, a soaring number of marketed Trifolium pratense (red clover) extract products have denoted that rising consumers are turning to natural alternatives manage postmenopausal symptoms. T. ethanolic (TPEE) showed immense potential for their uses in the treatment menopause complications including osteoporosis and hormone dependent diseases. Early diagnosis can increase chance efficient reduce fracture risks. Currently, most common is performed by using dual-energy x-ray...
Age-related osteoporosis affects people of both genders at any age especially postmenopausal women. The manifestation reduced bone strength leads to increased risk fracture. Currently, many have sought for plant-based supplements the management health. Red clover (Trifolium pratense) contains phytoestrogenic isoflavones which are known limit osteoclastic activity and reduce resorption. Our study aimed optimize condition preparation red ethanolic extract obtain highest yield while retaining...
Bis-diamine was developed as amebicidal and male contraceptive agents; however, it is also reported to induce characteristic congenital heart defects especially in the cardiac conotruncal area of rats. Because its defects, bis-diamine-induced animal models can be used for studying defects. However, comprehensive toxicological information regarding this model not available.In study, we investigated characterized an A single dose 200-mg bis-diamine administered by oral gavage pregnant rats on...