A5079558001- Forensic and Genetic Research
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- Mosquito-borne diseases and control
- Insect and Arachnid Ecology and Behavior
- Historical and Archaeological Studies
- Ancient and Medieval Archaeology Studies
- Animal Behavior and Reproduction
- Risk Perception and Management
- Forensic Anthropology and Bioarchaeology Studies
- Virology and Viral Diseases
- Linguistics and language evolution
- Insect Utilization and Effects
- Yersinia bacterium, plague, ectoparasites research
- Linguistics and Cultural Studies
- Viral Infections and Vectors
- Wildlife Ecology and Conservation
- Climate Change Communication and Perception
- Malaria Research and Control
- Insect symbiosis and bacterial influences
Flinders University
2024
The University of Adelaide
2017-2021
Pitzer College
2018
Pennsylvania State University
2016-2017
Centre for Cancer Biology
2017
South Australia Pathology
2017
Dengue virus (DENV) is a major global pathogen that causes significant morbidity and mortality in tropical subtropical areas worldwide. An improved understanding of the regions within DENV genome its encoded proteins are required for replication cycle will expedite development urgently therapeutics vaccines. We subjected an infectious to unbiased insertional mutagenesis used next-generation sequencing identify sites tolerate 15-nucleotide insertions during hepatic cell culture. This revealed...
When Roman administration and legions gradually withdrew from the outer provinces after fall of Western Empire, they created a power void filled by various groups. The dynamic Migration Period that followed is usually considered to have ended when Germanic Lombards allegedly left Central Europe were replaced Slavs. Whether or how Slavic tribes interacted, however, currently disputed. Here we report first direct archaeological find in support contact: bone fragment dated ~600 AD incised with...
Short tandem repeat (STR) variants are highly polymorphic markers that facilitate powerful population genetic analyses. STRs especially valuable in conservation and ecological research, yielding detailed information on structure short-term demographic fluctuations. Massively parallel sequencing has not previously been leveraged for scalable, efficient STR recovery. Here, we present a pipeline developing directly from high-throughput shotgun data without reference genome, an approach target...
ABSTRACT Secreted non-structural protein 1 (sNS1) is an important orthoflavivirus pathogenic factor that can induce vascular leakage; a key symptom of severe dengue disease. Given the role sNS1 in pathogenesis, defining molecular mechanisms NS1 secretion may contribute towards development NS1-targeting antiviral therapies. To this end, we performed customised membrane-trafficking siRNA screen to identify human host factors involved secretion. Our identified COPA, COPB2, and COPG1 as...
Abstract Mountain lions ( Puma concolor ) were once endemic across the United States. The Northeastern population of mountain has been largely nonexistent since early 1800s and was officially declared extinct in 2011. This regionally lion is Pennsylvania State University’s official mascot, where it referred to as ‘Nittany Lion’. Our goal this study use recent methodological advances ancient DNA massively parallel sequencing reconstruct complete mitochondrial (mtDNA) genomes multiple Nittany...
Abstract Short tandem repeat (STRs or microsatellites) variants, are highly polymorphic markers that facilitate powerful, high-precision population genetic analyses. STRs especially valuable in conservation and ecological research, yielding detailed information on structure short-term demographic flux. However, STR marker development analysis by conventional PCR-based methods imposes a workflow bottleneck is suboptimal for noninvasive sampling strategies such as fecal DNA recovery. While...