Diabetic ulcers have received much attention in recent years due to their high incidence and mortality, motivating the scientific community develop various strategies for such chronic disease treatments. However, therapeutic outcome of these approaches is highly compromised by invasive bacteria a severe inflammatory microenvironment. To overcome dilemmas, microenvironment-responsive self-delivery glucose oxidase@manganese sulfide (GOx@MnS) nanoparticles (NPs) are developed one-step...

Due to protection of extracellular polymeric substances, the therapeutic efficiency conventional antimicrobial agents is often impeded by their poor infiltration and accumulation in biofilm. Herein, one type surface charge adaptable nitric oxide (NO) nanogenerator was developed for biofilm permeation, retention eradication. This (PDG@Au-NO/PBAM) composed a core-shell structure: thermo-sensitive NO donor conjugated AuNPs on cationic poly(dopamine-co-glucosamine) nanoparticle (PDG@Au-NO)...

Aseptic loosening and bacterial infection pose significant challenges in the clinical application of titanium (Ti) orthopedic implants, which are primarily caused by insufficient osseointegration contamination. To address these issues, a responsive coating on Ti surface is constructed, achieves enhanced elimination on-demand release therapeutic gas hydrogen sulfide (H

Abstract Hydrogen sulfide (H 2 S) plays crucial inflammatory modulating roles, representing a promising candidate for anti‐inflammatory therapies. However, current H S delivery approaches lack sufficient specificity against response. Herein, regarding the overexpressed aminopeptidase N (APN) at inflammation sites, an APN‐activated self‐immolative carbonyl (COS)/H donor ( AlaCOS ) was developed response‐specific delivery. The compound showed sustained generation upon APN activation in...

Solid and microcellular poly(l-lactide)/poly(butylene adipate-co-terephthalate) (PLLA/PBAT) blends with or without poly(d-lactide) (PDLA) were prepared via melt blending batch foaming process supercritical carbon dioxide, respectively. The introduction of PDLA on the rheological properties, crystallization behavior dynamic mechanical properties PLLA matrix investigated. formed PLA stereocomplex between enhanced storage modulus complex viscosity PLLA/PBAT efficiently. Interestingly, addition...

With the increasing clinical use of invasive medical devices, various healthcare-associated infections (HAIs) caused by bacterial biofilm colonization biomedical devices have posed serious threats to patients. The formation biofilms makes it much more difficult and costly treat infections. Here, we report a nitric oxide (NO)-releasing gold nanocage (AuNC@NO) that is stimulated near-infrared (NIR) irradiation deliver NO generate hyperthermia for elimination. AuNC@NO was prepared immobilizing...

Understanding tourism carbon emissions and their influencing factors from the perspective of industrial linkages can inform policy-making in development sustainable tourism. Based on a combination environmental input–output (I-O) model structural decomposition analysis, this article develops novel framework for analyzing linkage pathways China’s linked to identifying driving affecting change embodied supply chain. Results reveal that most broad-sense or narrow-sense industry derive some...

As one of the gasotransmitters, therapeutic effects hydrogen sulfide (H2S) were reported widespread in recent years. Considering short physiological half-life and significant dose-dependent H2S, it is vital to achieve controlled H2S delivery for biomedical applications. Polymeric micelles have been explored regulate delivery. However, dilution-induced dissociation conditions limits their effects. The circulation stability polymeric could be improved through core-cross-linking, but reduced...

As watersheds are urbanized, the amount of impervious surfaces will be increased. such, water infiltration reduced, and volume surface runoff By retaining stormwater, best management practices (BMPs) used to mitigate hydrologic effects urbanization. Using Ludlow watershed in northern Kentucky as a case study, main objective this paper was identify most cost-effective arrangement BMPs reducing runoff. A simulation program employed model conditions under current future climate BMP arrangement....

Depleting tumoral lactate is a promising strategy to enhance the immune response and thereby suppressing tumorigenesis. However, direct use of oxidase (LOx), most straightforward lactate-eliminating agent, faces several issues including low stability, no targeting capacity. To solve these problems, “carrier-free” nanodrug LOx@manganese sulfide (LOx@MnS) was facilely prepared via biomineralization. This way, all constituents integrated in nanodrug, LOx, Mn2+, hydrogen (H2S), could be readily...

Hydrogen sulfide (H2S) plays crucial inflammatory modulating roles, representing a promising candidate for anti-inflammatory therapies. However, current H2S delivery approaches lack sufficient specificity against response. Herein, regarding the overexpressed aminopeptidase N (APN) at inflammation sites, an APN-activated self-immolative carbonyl (COS)/H2S donor (AlaCOS) was developed response-specific delivery. The compound showed sustained generation upon APN activation in presence of...

This paper argues the appearances of at least three generations’ replacement migrant workers since reform and open policy, which is first generation, new generation third generation. Under condition disparate family social circumstances, are no longer abstract groups with same degree homogeneity. The public tendency more clearly in aspect mobility motivations, city identity self-identity, employment industry, education skills training. Therefore, importance highlights increasingly. According...

Traditional structure of education is mainly supported by print media.The digitalization textbooks can turn abstract contents into representational contents, thus making it easier to understand and acquire knowledge in for primary school students.The teaching affairs will become more efficient through using digital textbooks.It significant focus on user experiences feelings when digitalizing textbooks.By designing a textbook Chinese, the authors argue that order better realize goals Chinese...

Recently, with the rapid development of cultural creative industry, there is an expanded size recruitment students in design professions colleges.And arises a fashion studying art design.But employment situation severe, resulting from teaching system putting less emphasis on practice and causing disconnection between talent cultivation industrial demand.In our country, higher education laws provide that basic mission to cultivate senior specialized talents ability.Innovation comes practice,...