A5036732375- Tuberculosis Research and Epidemiology
- Child Nutrition and Water Access
- Diagnosis and treatment of tuberculosis
- COVID-19 Clinical Research Studies
- Global Health and Epidemiology
- Mycobacterium research and diagnosis
- Healthcare Systems and Reforms
- Long-Term Effects of COVID-19
- Formal Methods in Verification
- HIV/AIDS Impact and Responses
- Real-Time Systems Scheduling
- Food Security and Health in Diverse Populations
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Software Engineering Methodologies
- Software Testing and Debugging Techniques
- Infectious Diseases and Tuberculosis
- Nutrition and Health in Aging
- Embedded Systems Design Techniques
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Clinical Reasoning and Diagnostic Skills
- Distributed systems and fault tolerance
- Software Reliability and Analysis Research
Boston University
2003-2025
Boston Medical Center
2020-2025
Indian Institute of Technology Kanpur
2024
Harvard University
2021-2022
Sheffield Teaching Hospitals NHS Foundation Trust
2018
Yale University
2018
University of Sheffield
2018
Yale New Haven Hospital
2017
University of Virginia
2014-2015
Cold Spring Harbor Laboratory
2012
Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal common cold, and these eCoVs share extensive sequence homology with human SARS coronavirus 2 (SARS-CoV-2). Here, we show that individuals with, as compared those without, a recent documented infection eCoV were tested at greater frequency respiratory infections but had similar rate of SARS-CoV-2 acquisition. Importantly, patients previously detected less-severe disease 2019 (COVID-19) illness. Our observations...
Approximately 20% of global tuberculosis incidence is attributable to undernutrition, increasing more than a third in India. Targeting nutritional interventions tuberculosis-affected households policy priority, but understanding epidemiological and economic impacts limited. We aimed estimate the population-level effect such an intervention. used previously published, age-stratified, compartmental transmission model India, incorporated explicit BMI strata linked disease progression treatment...
Undernutrition is the leading risk factor for tuberculosis (TB) globally. Its impact on treatment outcomes poorly defined.We conducted a prospective cohort analysis of adults with drug-sensitive pulmonary TB at 5 sites from 2015-2019. Using multivariable Poisson regression, we assessed associations between unfavorable and nutritional status based body mass index (BMI) initiation, BMI prior to disease, stunting, stagnant or declining after 2 months treatment. Unfavorable outcome was defined...
Objectives Patients with Covid-19 and obesity have worse clinical outcomes which may be driven by increased inflammation. This study aimed to characterize the association between in patients inflammatory markers. Methods We analyzed data for aged ≥18 years admitted a positive SARS-CoV-2 PCR test. used multivariate logistic regression determine BMI intensive care unit (ICU) transfer all-cause mortality. Inflammatory markers (C-reactive protein [CRP], lactate dehydrogenase [LDH], ferritin,...
Undernutrition is the leading cause of tuberculosis (TB) in India and associated with increased TB mortality. also decreases quality life economic productivity.
India's National Tuberculosis Elimination Programme (NTEP) covers diagnostic and therapeutic costs of TB treatment. However, persons living with (PLWTB) continue to experience financial distress due direct (payment for testing, treatment, travel, hospitalization, nutritional supplements) indirect (lost wages, loan interest, cost domestic helpers).To analyze the magnitude pattern TB-related from perspective Indian PLWTB.We identified relevant articles using key search terms ('tuberculosis,'...
Background Most individuals exposed to Mycobacterium tuberculosis (Mtb) develop latent infection (LTBI) and remain at risk for progressing active disease (TB). Malnutrition is an important factor driving progression from LTBI TB. However, the performance of blood-based TB signatures in malnourished with remains unexplored. The aim this study was determine if control had differences gene expression, immune pathways signatures. Methods We utilized data 50 tuberculin skin test positive...
Abstract Background Treatment of latent tuberculosis infection (LTBI) is a crucial component (TB) eradication plans in the United States (US). It estimated that 80% active TB cases arise from LTBI reactivation. Numerous gaps have been identified care cascade, leading to low rates treatment initiation and completion. duration has shown be significant factor influencing completion for treatment. Since 2020, Center Disease Control Prevention (CDC) recommends 4 months daily rifampin (4R) as...
Introduction Undernourished persons with tuberculosis (TB) (PWTB) are at increased risk of mortality, treatment failure and relapse. Nutritional support for PWTB has the potential to mitigate undernutrition. However, given ethical concerns, well-powered randomised control trials macronutrient unavailable inform policymakers, clinicians researchers about impact nutritional support. there is understand through a natural experiment. Benin Togo neighbouring countries in West Africa. Benin’s...
Tuberculosis (TB) mortality rose during the COVID-19 pandemic, as did food insecurity worldwide. Undernourished individuals are at increased risk for incident TB disease and mortality. This study examines impact of COVID lockdowns on security households with in Southern India. In-depth interviews focus group discussions were conducted household contacts enrolled a nutritional intervention study, Puducherry Tamil Nadu (2018–2024), which provided persons six-month intervention. During...
Background: The effectiveness of pre-exposure prophylaxis (PrEP) in preventing HIV depends on consistent use, particularly during periods increased risk. Depression, which disproportionately affects gay, bisexual, and other men who have sex with (GBMSM), may hinder sustained PrEP engagement. This study examines how depression impacts use among GBMSM the first 18 months after initiating oral PrEP. Methods: We analyzed electronic health records for adult prescribed between January 2015...