A5014206789- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Alkyne Reactions
- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Asymmetric Synthesis and Catalysis
- Organometallic Complex Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Advanced Combustion Engine Technologies
- Fullerene Chemistry and Applications
- Hydraulic and Pneumatic Systems
- Sulfur-Based Synthesis Techniques
- Real-time simulation and control systems
- Fault Detection and Control Systems
- Industrial Technology and Control Systems
- Synthesis and Properties of Aromatic Compounds
- Boron and Carbon Nanomaterials Research
- Wind and Air Flow Studies
- Energetic Materials and Combustion
- Axial and Atropisomeric Chirality Synthesis
- Organic Chemistry Cycloaddition Reactions
- Bioinformatics and Genomic Networks
Huazhong University of Science and Technology
2023-2025
Shijiazhuang Tiedao University
2015-2025
Guilin Medical University
2024
Southeast University
2022-2024
Northwestern Polytechnical University
2024
Fudan University Shanghai Cancer Center
2024
First Hospital of Shijiazhuang
2015-2023
China University of Mining and Technology
2022-2023
Sichuan University of Science and Engineering
2018-2023
Northeastern University
2023
The first enantioselective construction of a new class axially chiral naphthyl-indole skeletons has been established by organocatalytic asymmetric coupling reactions 2-naphthols with 2-indolylmethanols (up to 99 % yield, 97:3 e.r.). This approach not only affords type heterobiaryl backbone, but also provides catalytic strategy for constructing biaryl scaffolds making use the C3-electrophilicity 2-indolylmethanols.
Abstract Background Lactylation, a novel contributor to post-translational protein modifications, exhibits dysregulation across various tumors. Nevertheless, its intricate involvement in colorectal carcinoma, particularly for non-histone lactylation and intersection with metabolism immune evasion, remains enigmatic. Methods Employing immunohistochemistry on tissue microarray clinical information immunofluorescence cell lines, we investigated the presence of global association development...
2,4-Oxazole is an important structural motif in various natural products. An efficient modular synthesis of this structure has been achieved via a [3 + 2] annulation between terminal alkyne and carboxamide using gold-catalyzed oxidation strategy. The postulated reactive intermediate, α-oxo gold carbene, previously known to be highly electrophilic hence unlikely trapped by stoichiometric external nucleophiles, coerced react smoothly with the en route oxazole ring P,N- or P,S-bidentate ligand...
The carbonylation of carbenes through catalytic cycles is highly desirable due to the importance ketene-mediated reactions in organic synthesis. In this investigation, a efficient and mild approach toward ketene intermediates has been developed based on Pd-catalyzed diazo compounds with CO. When α-diazocarbonyl or N-tosylhydrazone salts are heated presence palladium catalyst under atmospheric pressure CO, formed situ, where they undergo further various nucleophiles such as alcohols, amines,...
A novel Pd-catalyzed double C–S bond formation coupling reaction has been developed. This protocol, in which Na2S2O3 was used as sulfurating reagent metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, are structural elements numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.
The first rare earth metal terminal imido complex has been isolated and structurally characterized. an extremely short M–N bond length a nearly linear M–N–C angle. DFT studies showed two p orbitals of Nimido atom form bonds with d ion.
Gold-catalyzed intramolecular oxidation of terminal alkynes with an arenesulfinyl group as the tethered oxidant is a reaction high impact in gold chemistry, it introduced to field highly valued concept carbene generation via alkyne oxidation. The proposed intermediacy α-oxo carbenes these reactions, however, has never been substantiated. Detailed experimental studies suggest that involvement such reactive intermediates formation dihydrobenzothiepinones unlikely. Instead, [3,3]-sigmatropic...
Abstract A gold‐catalyzed highly regio‐ and chemoselective oxidative ring expansion of 2‐alkynyl‐1,2‐dihydropyridines its analogues using pyridine‐N‐oxide as the oxidant has been developed. Ring proceeds through exclusive 1,2‐migration a vinyl or phenyl group, whereas no 1,2‐H 1,2‐N migration take place. The reaction provides an efficient attractive route to various types medium‐sized azepine derivatives in generally high excellent yields with broad functional group tolerance. DFT studies...
The mechanisms of reductive functionalization CO2 to formamide catalyzed by N-heterocyclic carbene (NHC) were comprehensively studied with DFT calculations. New activation mode much lower energy barrier than those proposed before was discovered. In this reaction, NHC acts as neither a nor silane activator, but precursor the real catalyst, i.e., in situ formed ionic liquid [NHCH](+)[Carbamate](-). loose contact ion pair, negatively charged O atom carbamate anion becomes new active site and is...
The brittle minerals and shale bedding seriously affect the fracture performance of shale, macroscopic mechanical experimental methods cannot separate these key factors for analysis. In this study, nanoindentation tests were conducted on clay carbonate shales, effects felsic micromechanical characteristics evaluated.Based extended cavity model, analytical formulas energy density total function during indentation process layered discussed. results showed that with increase mineral content,...
Copper-catalyzed cross-coupling of N-tosylhydrazones with N-iminopyridinium ylides leads to the direct C–H alkylation. This bond alkylation transformation uses inexpensive CuI as catalyst without any ligand. The reaction is operationally simple and conducted under mild conditions, giving corresponding alkylated pyridines in moderate good yields. DFT calculation provides insights into mechanism, suggesting that proceeds through Cu carbene migratory insertion process.
The mechanism of the chiral phosphoric acid catalyzed Baeyer-Villiger (B-V) reaction cyclobutanones with hydrogen peroxide was investigated by using a combination experimental and theoretical methods. Of two pathways that have been proposed for present reaction, pathway involving peroxyphosphate intermediate is not viable. progress kinetic analysis indicates partially inhibited gamma-lactone product. Initial rate measurements suggest follows Michaelis-Menten-type kinetics consistent...
The mechanisms of trifluoromethylation with hypervalent iodine reagent (Togni's 1) have been comprehensively studied by density functional theory (DFT) calculations. results show that there are two general reaction modes for 1: (I) Mode-A, acting as a CF3• free radical source. When one-electron reductants available in the system, such CuI, FeII, TEMPONa, or electron-rich lithium enolate, 1 will be reduced via single-electron transfer (SET) and give out concertedly. In CuI-catalyzed terminal...
Abstract The first enantioselective construction of a new class axially chiral naphthyl‐indole skeletons has been established by organocatalytic asymmetric coupling reactions 2‐naphthols with 2‐indolylmethanols (up to 99 % yield, 97:3 e.r.). This approach not only affords type heterobiaryl backbone, but also provides catalytic strategy for constructing biaryl scaffolds making use the C3‐electrophilicity 2‐indolylmethanols.
A carbapenem-nonsusceptible Enterobacter aerogenes strain named 3-SP was isolated from a human case of pneumonia in Chinese teaching hospital. NDM-1 carbapenemase is produced by pNDM-BJ01-like conjugative plasmid designated p3SP-NDM to account for carbapenem resistance 3-SP. fully sequenced and compared with all publically available plasmids. The genetic differences between pNDM-BJ01 include only 18 single nucleotide polymorphisms, 1 bp deletion 706 deletion. harbor an identical Tn125...
The unique cobalt(I)-NHC complex [Co(IEt)4][BPh4] (1) (IEt = 1,3-diethyl-4,5-dimethylimidazole-2-ylidene) and its analogues employing other carbene ligands were prepared by the reactions of [Co(PPh3)3Cl] with free followed anion exchange. X-ray diffraction revealed 1 features a homoleptic cation [Co(IEt)4]+ square-planar geometry. Electrochemical studies showed complexes support redox series [Co(IEt)4]+/2+/3+, which divalent has been synthesized structurally characterized as in...
FeCl(3)6 H(2)O- and FeBr(3)-catalyzed Prins cyclization/halogenation of alkynyl aldehyde acetals has been realized with acetyl chloride or bromide as halogen source in dichloromethane to afford 2-(1-halobenzylidene alkylidene)-substituted five-membered carbo- heterocycles, thus provides an alternative route for vinylic C-Cl C-Br bond formation. Five- eight-membered cyclic enones were efficiently synthesized by FeCl(3)6.H(2)O-catalyzed intramolecular cyclization acetone under mild conditions....
Abstract We describe the Suzuki coupling reaction of ( E )‐(β‐trifluoromethyl)vinyldiphenylsulfonium salts with arylboronic acid. The highly efficient and selective provides a useful mild method for synthesis trifluoromethylated alkenes dienes. Subsequent DFT studies showed that oxidative addition transition state vinyl C–S bond is much more favorable (11.7 kcal mol –1 ) than aryl bond.
Abstract Gold‐catalyzed cascade cyclization/1,2‐rearrangement of 1‐(2‐furanyl)phenyl propargyl alcohols has been developed, which provides a rapid and efficient access to multisubstituted 1‐naphthols bearing an enal or enone moiety with high stereoselectivity. The ( Z )‐ E )‐stereochemistry can be easily controlled by choosing protected‐ non‐protected substrates. utility the methodology illustrated in first total synthesis wailupemycin G.
(Cyclopropylidenecyclohexyl)benzene derivatives, a kind of methylenecyclopropane (MCP) containing cyclohexyl group, can undergo an interesting tandem intramolecular C-H and C-C bond activation through dehydrogenated rearrangement in the presence AuPPh(3)Cl/AgOTf by transferring three hydrogen atoms from cyclohexane to cyclopropane, affording corresponding biaryl derivatives moderate good yields. The reaction mechanism has also been carefully investigated deuterium labeling experiments DFT...