A5074877099- Single-cell and spatial transcriptomics
- Urban Design and Spatial Analysis
- Urban Green Space and Health
- Land Use and Ecosystem Services
- Adipose Tissue and Metabolism
- Molecular Biology Techniques and Applications
- Business Strategy and Innovation
- Human Mobility and Location-Based Analysis
- Visual Attention and Saliency Detection
- Economic and Environmental Valuation
- Healthcare Systems and Technology
- Exercise and Physiological Responses
- Image Retrieval and Classification Techniques
- Complex Systems and Decision Making
- Cell Image Analysis Techniques
- Facilities and Workplace Management
- Consumer Retail Behavior Studies
- Urban Transport and Accessibility
- Advanced Biosensing Techniques and Applications
- MicroRNA in disease regulation
- Health, Environment, Cognitive Aging
- Immune cells in cancer
- Innovative Approaches in Technology and Social Development
- Muscle Physiology and Disorders
- Innovation and Knowledge Management
University of Michigan
2013-2025
A. Alfred Taubman Health Care Center
2013-2014
Spatial layouts can significantly influence the formation and outcomes of social relationships. Physical proximity is thus essential to understanding elemental building blocks networks, dyads. Situating relationships in space instrumental formulating better models collaboration information sharing organizations more robust theories networks their effects. We propose, develop, test a concept, functional zone, which effectively captures Festinger et al.’s classic description “functional...
ABSTRACT Spatial transcriptomics (ST) technologies represent a significant advance in gene expression studies, aiming to profile the entire transcriptome from single histological slide. These techniques are designed overcome constraints faced by traditional methods such as immunostaining and RNA situ hybridization, which capable of analyzing only few target genes simultaneously. However, application ST histopathological analysis is also limited several factors, including low resolution,...
Research on the enabling factors of innovation has most often addressed either social component organizations or spatial dimensions involved in process. Few studies have examined link from layout and networks to innovation. Social play important roles structuring communication, collaboration, access knowledge, knowledge transformation. These processes are both antecedent part Spatial structures patterns circulation, proximity, awareness others, encounter an organization. interrelationships...
Abstract Sequencing-based spatial transcriptomics (sST) enables transcriptome-wide gene expression mapping but falls short of reaching the optical resolution (200–300 nm) imaging-based methods. Here, we present Seq-Scope-X (Seq-Scope-eXpanded), which empowers submicrometer-resolution Seq-Scope with tissue expansion to surpass this limitation. By physically enlarging tissues, minimizes transcript diffusion effects and increases feature density by an additional order magnitude. In liver...
Spatial transcriptomics (ST) technologies have advanced to enable transcriptome-wide gene expression analysis at submicron resolution over large areas. Analysis of high-resolution ST data relies heavily on image-based cell segmentation or gridding, which often fails in complex tissues due diversity and irregularity size shape. Existing segmentation-free methods scale only small regions a number genes, limiting their utility high-throughput studies. Here we present FICTURE, spatial...
Abstract Skeletal muscle is essential for both movement and metabolic processes, characterized by a complex ordered structure. Despite its importance, detailed spatial map of gene expression within tissue has been challenging to achieve due the limitations existing technologies, which struggle provide high-resolution views. In this study, we leverage Seq-Scope technique, an innovative method that allows observation entire transcriptome at unprecedented submicron resolution. By applying...
Machine learning, particularly classification algorithms, constructs mathematical models from labeled data that can predict labels for new data. Using its capability to identify distinguishing patterns among multi-dimensional data, we investigated the impact of three factors on observation architectural scenes: Individuality, education, and image stimuli. An analysis eye-tracking revealed (1) a velocity histogram was unique individuals, (2) students architecture other disciplines could be...
Spatial layouts can have significant influences on the formation and outcomes of social relationships. Physical proximity is thus essential to understanding elemental building blocks networks, dyads. Situating relationships in space instrumental formulating better models collaboration information-sharing organizations more robust theories networks their effects. We propose, develop, test a concept, functional zone, which effectively captures Festinger et al's (1950) classic description...
Research on the enabling factors of innovation has focused either social component organizations or spatial dimensions involved in process. But few have examined aggregate consequences link from layout to networks innovation. Preliminary results this NSF sponsored research were presented at ARCC 2012. The explores how and promote among professionals working indifferent research-intensive organizations. associations between within these organization’s structure are investigated. This paper...